Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Diabetologia

• Publication date

  2011-07-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-011-2249-7PMID 21796486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

  1997cited by this paper
• Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.

  1997cited by this paper
• Metabolic Fate of Glucose in Purified Islet Cells

  1997influential reference
• Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.

  1995cited by this paper
• PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

  1995cited by this paper
• Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

  1992cited by this paper
• Type II Diabetes, Glucose “Non-Sense,” and Islet Desensitization

  1989cited by this paper
• Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.

  1986cited by this paper
• The role of the pentose phosphate shunt in glucose induced insulin release: in vitro studies with 6-aminonicotinamide, methylene blue, NAD + , NADH, NADP + , NADPH and nicotinamide on isolated pancreatic rat islets.

  1973cited by this paper
• Enzymes of glucose metabolism in normal mouse pancreatic islets.

  1970cited by this paper
• Pentose cycle in isolated islets during glucose-stimulated insulin release.

  1970cited by this paper
• Islet-cell metabolism during insulin release. Effects of glucose, citrate, octanoate, tolbutamide, glucagon and theophylline.

  1969cited by this paper
• The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells.

  1969cited by this paper
• Effect of Hyperglycemia on the Hexose Monophosphate Shunt in Islets of Langerhans

  1968cited by this paper
• Mechanism of action of transaldolase.

  1962cited by this paper
• Mechanism of action of transaldolase. I. Crystalization and properties of yeast enzyme.

  1961cited by this paper
• Pyridine nucleotide metabolism: mechanism of action of the niacin antagonist, 6-aminonicotinamide.

  1958cited by this paper
• Inhibition of Phosphoglucose Isomerase

  1956cited by this paper
• 6-Aminonicotinamide--a Potent Nicotinamide Antagonist.

  1955cited by this paper

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  2024cites this paper
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  2024cites this paper
• Checkpoint kinase 2 controls insulin secretion and glucose homeostasis

  2023cites this paper
• Bidirectional Mendelian randomization study of insulin-related traits and risk of ovarian cancer

  2023cites this paper
• Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets.

  2023cites this paper
• The Pancreatic β-Cell: The Perfect Redox System

  2021cites this paper
• Redox Signaling is Essential for Insulin Secretion

  2021cites this paper
• Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion

  2021cites this paper
• Mechanisms controlling pancreatic islet cell function in insulin secretion

  2021cites this paper
• Metabolomics Analysis of Nutrient Metabolism in β-Cells.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
• α2-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling

  2018cites this paper
• Metabolomics applied to islet nutrient sensing mechanisms

  2017cites this paper
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• Mechanisms of the amplifying pathway of insulin secretion in the β cell.

  2017cites this paper
• Metabolomics and Metabolic Diseases: Where Do We Stand?

  2017cites this paper
• Metabolomics applied to the pancreatic islet.

  2016cites this paper
• Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

  2016cites this paper
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  2016cites this paper
• Acute intravenous glucose load impairs early insulin secretion and insulin content in islet β cells in mice.

  2016cites this paper
• Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development.

  2016cites this paper
• Mitochondrial dysfunction of 3t3-l1 adipocytes induced by oligomycin and antimycin a

  2015cites this paper
• transcriptome and differentiation of human pancreatic islets

  2015cites this paper
• Stimulus-Section Coupling in Endocrine Cell Models

  2015cites this paper
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  2015cites this paper
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