Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression - The Northern Finland Birth Cohort 1966 study.

There is limited knowledge available on the association of vitamin D with psychiatric disorders in young adults. We aimed to investigate vitamin D levels and associating factors in schizophrenia, other psychoses and non-psychotic depression. We studied 4,987 participants from the Northern Finland Birth Cohort 1966 (31 years) with available serum 25-hydroxyvitamin D [25(OH)D] measurements. The final sample was divided into four groups: schizophrenia (n = 40), other psychoses (n = 24), non-psychotic depression (n = 264) and control (n = 4659). To account for the influence of environmental and technical covariates, we generated a vitamin D score variable with correction for season, sex, batch effect and latitude. We further examined how vitamin D levels correlate with anthropometric, lifestyle, socioeconomic and psychiatric measures. Neither serum 25(OH)D concentration nor vitamin D score differed between schizophrenia, other psychoses, non-psychotic depression and control group. The prevalence of vitamin D deficiency was 3.2%, insufficiency 25.5%, and sufficiency 71.3%. Low vitamin D score correlated with regular smoking in the group with schizophrenia. No difference was observed in other psychiatric conditions. We did not find any difference in vitamin D status between schizophrenia, psychoses, non-psychotic depression and control groups, but future studies are warranted to elucidate the role of vitamin D in psychiatric conditions.

• Publication year

  2019

• Venue

  Psychiatry Research

• Publication date

  2019-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.psychres.2019.02.060PMID 30876732
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypovitaminosis D is associated with depression and anxiety in schizophrenia: results from the national FACE-SZ cohort. Running title: hypovitaminosis D, depression and anxiety in schizophrenia

  2020cited by this paper
• Counting up the risks: How common are risk factors for morbidity and mortality in young people with psychosis?

  2018cited by this paper
• Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

  2018cited by this paper
• Correlates of Vitamin D in Psychotic Disorders: A comprehensive Systematic Review Psychiatry Research

  2018cited by this paper
• The association between neonatal vitamin D status and risk of schizophrenia

  2018cited by this paper
• Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation

  2018cited by this paper
• New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis

  2017cited by this paper
• Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966

  2017cited by this paper
• Correlates of vitamin D in psychotic disorders: A comprehensive systematic review.

  2017cited by this paper
• Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain

  2017cited by this paper
• Investigating causality in the association between 25(OH)D and schizophrenia

  2016cited by this paper
• How much physical activity do people with schizophrenia engage in? A systematic review, comparative meta-analysis and meta-regression.

  2016cited by this paper
• 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966

  2016cited by this paper
• Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.

  2016cited by this paper
• Physical Activity Patterns of People Affected by Depressive and Anxiety Disorders as Measured by Accelerometers: A Cross-Sectional Study

  2015cited by this paper
• Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator.

  2015cited by this paper
• Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States

  2014cited by this paper
• Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: therapeutic implications for add-on vitamin D augmentation

  2014cited by this paper
• Serum vitamin D levels in relation to schizophrenia: a systematic review and meta-analysis of observational studies.

  2014cited by this paper
• Depressive symptoms, diet quality, physical activity, and body composition among populations in Nova Scotia, Canada: report from the Atlantic Partnership for Tomorrow's Health.

  2014cited by this paper
• Vitamin D as a neurosteroid affecting the developing and adult brain.

  2014cited by this paper
• Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health

  2013cited by this paper
• Vitamin D deficiency and depression in adults: systematic review and meta-analysis

  2013cited by this paper
• Vitamin D and psychosis: mini meta-analysis.

  2013cited by this paper
• The association between physical fitness and depressive symptoms among young adults: results of the Northern Finland 1966 birth cohort study

  2013cited by this paper
• Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level

  2011cited by this paper
• Prevalence and correlates of vitamin D deficiency in US adults.

  2011cited by this paper
• The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

  2010cited by this paper
• Agreement between self‐reported and pharmacy data on medication use in the Northern Finland 1966 Birth Cohort

  2010cited by this paper
• Global vitamin D status and determinants of hypovitaminosis D

  2009cited by this paper
• Non-participation in a field survey with respect to psychiatric disorders

  2008cited by this paper
• REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel- releasing intrauterine device in a general population

  2008cited by this paper
• Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency

  2008cited by this paper
• Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population.

  2008cited by this paper
• Vitamin D deficiency.

  2007cited by this paper
• Non-participation may bias the results of a psychiatric survey

  2007cited by this paper
• Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain.

  2005cited by this paper
• Early Life Factors and Blood Pressure at Age 31 Years in the 1966 Northern Finland Birth Cohort

  2004cited by this paper
• Predictors of abdominal obesity among 31-y-old men and women born in Northern Finland in 1966

  2004cited by this paper
• Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line

  2003cited by this paper
• Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin.

  1988cited by this paper
• The longitudinal study of the northern Finland birth cohort of 1966.

  1988cited by this paper

• Investigating the Role of Vitamin D in Enhancing Duloxetine and Fluoxetine Efficacy: Mechanistic Insights Into NRF2 Activation, Oxidative Stress, and Neurochemical Modulation

  2025cites this paper
• Nutritional interventions for early psychosis: a systematic review and network meta-analysis

  2024cites this paper
• Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

  2023cites this paper
• Vitamin D Levels among Adult Psychiatric Inpatients and the Association with Psychosis

  2023cites this paper
• Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

  2023influential citation
• Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

  2022cites this paper
• Serum vitamin-D level and major depressive disorder in Upper Egypt

  2022cites this paper
• 25(OH)D levels are decreased in patients with difficult-to-treat depression

  2022cites this paper
• Relationship of serum homocysteine and vitamin D with positive, negative, and extrapyramidal symptoms in schizophrenia: a case–control study in Iran

  2022cites this paper
• Relationship between vitamin D deficiency and psychophysiological variables: a systematic review of the literature

  2021cites this paper
• Vitamin D insufficiency and its contributing factors in primary school-aged children in Indonesia, a sun-rich country

  2021cites this paper
• Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective

  2021cites this paper
• Vitamin D and the Risks of Depression and Anxiety: An Observational Analysis and Genome-Wide Environment Interaction Study

  2021cites this paper
• Vitamin D serum level in major depressive disorder and schizophrenia

  2020cites this paper
• Effects of vitamin D supplementation on depression and some involved neurotransmitters.

  2020cites this paper
• Vitamin D and N-Acetyl cysteine supplementation in treatment resistant depressive disorder patients: a general review.

  2020cites this paper
• Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States

  2020cites this paper
• Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats

  2020cites this paper
• Vitamin D Deficiency as a Risk Factor for Schizophrenia: A meta-analysis of Observational Studies

  2019cites this paper
• The relationship between Vitamin D and depressive disorders.

  2019cites this paper
• Vitamin D Deficiency for Patients with Depression (case control study)

  year unknowncites this paper