Large fiber size in skeletal muscle is metabolically advantageous

Skeletal muscle fibre size is highly variable, and while diffusion appears to limit maximal fibre size, there is no paradigm for the control of minimal size. The optimal fibre size hypothesis posits that the reduced surface area to volume in larger fibres reduces the metabolic cost of maintaining the membrane potential, and so fibres attain an optimal size that minimizes metabolic cost while avoiding diffusion limitation. Here we examine changes during hypertrophic fibre growth in metabolic cost and activity of the Na+-K+-ATPase in white skeletal muscle from crustaceans and fishes. We provide evidence for a major tenet of the optimal fibre size hypothesis by demonstrating that larger fibres are metabolically cheaper to maintain, and the cost of maintaining the membrane potential is proportional to fibre surface area to volume. The influence of surface area to volume on metabolic cost is apparent during growth in 16 species spanning a 20-fold range in fibre size, suggesting that this principle may apply widely. Energy demand in muscle is largely due to maintaining the membrane potential of muscle fibres. Jimenez et al.study the metabolic cost of maintaining the membrane potential of muscle fibres across different species of crustaceans and fishes, and find that larger fibres are metabolically cheaper to maintain.

• Publication year

  2013

• Venue

  Nature Communications

• Publication date

  2013-07-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncomms3150PMID 23851638PMCID 3728711
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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