Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

No abstract is available for this paper.

• Publication year

  2016

• Venue

  HYPERTENSION

• Publication date

  2016-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.115.06062PMID 26573705PMCID PMC4837959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• This old heart: Cardiac aging and autophagy.

  2015cited by this paper
• Minireview: Autophagy in pancreatic β-cells and its implication in diabetes.

  2015cited by this paper
• Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes

  2014cited by this paper
• Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

  2014cited by this paper
• The interplay between autophagy and apoptosis in the diabetic heart.

  2014cited by this paper
• Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins.

  2014cited by this paper
• Autophagy‐related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex

  2014cited by this paper
• Catalase Overexpression Prevents Nuclear Factor Erythroid 2–Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice

  2014cited by this paper
• Enhanced autophagy ameliorates cardiac proteinopathy.

  2013cited by this paper
• Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure.

  2013cited by this paper
• The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

  2013cited by this paper
• Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.

  2013cited by this paper
• Keap1 degradation by autophagy for the maintenance of redox homeostasis

  2012cited by this paper
• Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy.

  2011cited by this paper
• Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

  2010cited by this paper
• p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription*

  2010cited by this paper
• Methods in mammalian autophagy research.

  2010cited by this paper
• CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.

  2010cited by this paper
• The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

  2010cited by this paper
• Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress

  2009cited by this paper
• Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models

  2009cited by this paper
• Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

  2009cited by this paper
• Targeting the Nrf2 pathway against cardiovascular disease

  2009cited by this paper
• A method to measure cardiac autophagic flux in vivo

  2008cited by this paper
• Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice

  2007cited by this paper
• Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology.

  2007cited by this paper
• Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.

  2007cited by this paper
• GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

  2007cited by this paper
• Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

  2007cited by this paper
• The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

  2007cited by this paper
• Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.

  2006cited by this paper
• Toward transcriptional therapies for the failing heart: chemical screens to modulate genes.

  2005cited by this paper
• Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence.

  2004cited by this paper
• Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure.

  2002cited by this paper
• Expression of R120G–αB-Crystallin Causes Aberrant Desmin and αB-Crystallin Aggregation and Cardiomyopathy in Mice

  2001cited by this paper
• Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice.

  2001cited by this paper
• Increased cardiac angiotensin II levels induce right and left ventricular hypertrophy in normotensive mice.

  2000cited by this paper
• The renin-angiotensin system and experimental heart failure.

  1999cited by this paper
• A Catalytically Active Jak2 Is Required for the Angiotensin II-dependent Activation of Fyn*

  1999cited by this paper
• Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system.

  1998cited by this paper

• Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.

  2025cites this paper
• Loganin ameliorates left ventricular fibrosis and dysfunction induced by pressure overload via the Sirt1/AKT/TGF-β1 signaling pathway

  2025cites this paper
• Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy

  2025cites this paper
• The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

  2025cites this paper
• Intensity, Duration, and Context Dependency of the Responses to Nutrient Surplus and Deprivation Signaling in the Heart: Insights Into the Complexities of Cardioprotection

  2025cites this paper
• Nuclear factor, erythroid 2 like 2 (NRF2)‐mediated disruption of iron homeostasis drives myocardial infarction progression

  2025influential citation
• FGF9 alleviates diabetic cardiomyopathy by activating Nrf2 via SQSTM1/p62-Keap1 in mice

  2025cites this paper
• An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress

  2025cites this paper
• Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

  2025cites this paper
• Adverse Effects of Nrf2 in Different Organs and the Related Diseases

  2024cites this paper
• Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases

  2024cites this paper
• Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders

  2024cites this paper
• Ironing out the role of Nrf2 in cardiac iron metabolism during myocardial infarction

  2024cites this paper
• Dimethyl Fumarate Mediates Sustained Vascular Smooth Muscle Cell Remodeling in a Mouse Model of Cerebral Aneurysm

  2024cites this paper
• Nrf2 mediated signaling axis in heart failure: potential pharmacological receptor.

  2024cites this paper
• Celastrol alleviates diabetic vascular injury via Keap1/Nrf2-mediated anti-inflammation

  2024cites this paper
• Nrf2-Keap1 in Cardiovascular Disease: Which is the Cart and Which the Horse?

  2024cites this paper
• Pharmacological Activities, Therapeutic Effects, and Mechanistic Actions of Trigonelline

  2024cites this paper
• Indoxyl sulphate‐initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor‐erythroid‐2‐related factor 2

  2024cites this paper
• Upregulation of Nrf2 in myocardial infarction and ischemia-reperfusion injury of the heart

  2024cites this paper
• Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis.

  2024cites this paper
• Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome

  2024cites this paper
• Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy

  2023cites this paper
• Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

  2023cites this paper
• Beyond Antioxidation: Keap1–Nrf2 in the Development and Effector Functions of Adaptive Immune Cells

  2023cites this paper
• Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis.

  2023cites this paper
• Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases

  2023cites this paper
• The dark side of NRF2 in arsenic carcinogenesis.

  2023cites this paper
• Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

  2023cites this paper
• Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells

  2023cites this paper
• A NRF2/β3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress

  2023cites this paper
• POTENTIAL OF MEDIUM TO LONG-TERM FASTING TO TRIGGER AN AUTOIMMUNE RESPONSE THROUGH HYPERAGGRESSIVE AUTOPHAGY

  2023cites this paper
• Naoxintong Capsule Activates the Nrf2/HO-1 Signaling Pathway and Suppresses the p38α Signaling Pathway Via Estrogen Receptors to Ameliorate Heart Remodeling in Female Mice With Postmenopausal Hypertension

  2022cites this paper
• Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart

  2022cites this paper
• Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives

  2022cites this paper
• Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction

  2022cites this paper
• Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

  2022cites this paper
• Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation

  2022cites this paper
• The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease.

  2022cites this paper
• The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2

  2022cites this paper
• Induction of Cardiac Pathology: Endogenous versus Exogenous Nrf2 Upregulation

  2022cites this paper
• Nrf2-Mediated Dichotomy in the Vascular System: Mechanistic and Therapeutic Perspective

  2022cites this paper
• Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

  2022cites this paper
• Diabetes-induced chronic heart failure is due to defects in calcium transporting and regulatory contractile proteins: cellular and molecular evidence

  2022cites this paper
• Correlative study on heavy metal-induced oxidative stress and hypertension among the rural population of Malwa Region of Punjab, India

  2022cites this paper
• The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

  2022cites this paper
• Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System

  2021cites this paper
• Regulation of Nrf2 signaling pathway in heart failure: Role of extracellular vesicles and non-coding RNAs.

  2021cites this paper
• β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension

  2021cites this paper
• Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

  2021cites this paper
• Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury

  2021cites this paper
• Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1-Nrf2 signalling pathway.

  2021cites this paper
• TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4

  2021cites this paper
• Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.

  2021cites this paper
• Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy

  2020cites this paper
• NRF2 in Cardiovascular Diseases: a Ray of Hope!

  2020cites this paper
• Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

  2020cites this paper
• Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux

  2020cites this paper
• An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.

  2020cites this paper
• The Dark Side of Nrf2 in the Heart

  2020cites this paper
• CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes.

  2020cites this paper
• Potential risk of hyperuricemia: leading cardiomyocyte hypertrophy by inducing autophagy.

  2020cites this paper
• The Role of Nrf2 in the Cardiovascular System and Atherosclerosis

  2020cites this paper
• Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts

  2020cites this paper
• Nrf2 and its Modulation in Inflammation

  2020cites this paper
• Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

  2020cites this paper
• LncRNA 2810403D21Rik/Mirf promotes ischemic myocardial injury by regulating autophagy through targeting Mir26a

  2020cites this paper
• MiR-153 regulates cardiomyocyte apoptosis by targeting Nrf2/HO-1 signaling

  2019cites this paper
• Research Progress in Cardiovascular Pharmacology

  2019cites this paper
• Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2/AhR.

  2019cites this paper
• Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy.

  2019cites this paper
• GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species

  2019cites this paper
• Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation.

  2019cites this paper
• Bisdemethoxycurcumin protects cardiomyocyte mainly depends on Nrf2/HO-1 activation mediated by PI3K/AKT pathway.

  2019cites this paper
• Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence.

  2018cites this paper
• Neferine modulates IGF‐1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts

  2018cites this paper
• Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF‐&bgr;/ smads pathways in rat heart

  2018cites this paper
• Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress

  2018cites this paper
• Interplay Among Oxidative Stress, Redox Signaling, ER Stress, Autophagy, and Protein Ubiquitylation in Cardiometabolic Disorders

  2018cites this paper
• Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway

  2018cites this paper
• Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

  2018cites this paper
• Novel Therapies Targeting Cardioprotection and Regeneration.

  2017cites this paper
• Autophagy in health and disease: focus on the cardiovascular system.

  2017cites this paper
• Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.

  2017cites this paper
• Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2.

  2017cites this paper
• The Role Of Cyclin-Dependent Kinase 8 In Vascular Disease

  2017cites this paper
• TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.

  2017cites this paper
• Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

  2017cites this paper
• Tin protoporphyrin activates the oxidant‐dependent NRF2‐cytoprotective pathway and mitigates acute kidney injury

  2017cites this paper
• Drug Discovery from Mother Nature

  2016cites this paper
• Transcriptional and post-transcriptional regulation of Nrf2 in the heart by the deubiquitinase CYLD

  2016cites this paper
• CDDO and Its Role in Chronic Diseases.

  2016cites this paper
• Nrf2 as a key player of redox regulation in cardiovascular diseases.

  2016cites this paper
• The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases

  2016cites this paper