PET Imaging of Nicotinic Acetylcholine Receptors in Baboons with 18F-AZAN, a Radioligand with Improved Brain Kinetics

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Nuclear Medicine

• Publication date

  2012-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2967/jnumed.111.092338PMID 22173841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited

  2010influential reference
• Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography.

  2010cited by this paper
• Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

  2010cited by this paper
• 18F-ZW-104: A New Radioligand for Imaging Neuronal Nicotinic Acetylcholine Receptors—In Vitro Binding Properties and PET Studies in Baboons

  2009influential reference
• Volume Index

  2009cited by this paper
• Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors.

  2009cited by this paper
• In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro‐fluoro‐homoepibatidine

  2008cited by this paper
• Quantification of nicotinic acetylcholine receptors in the human brain with PET: Bolus plus infusion administration of 2-[18F]F-A85380

  2008cited by this paper
• Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.

  2008cited by this paper
• Validation of an Extracerebral Reference Region Approach for the Quantification of Brain Nicotinic Acetylcholine Receptors in Squirrel Monkeys with PET and 2-18F-Fluoro-A-85380

  2007cited by this paper
• Handbook of contemporary neuropharmacology

  2007cited by this paper
• Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands

  2007cited by this paper
• Neuronal Nicotinic Receptors: One Hundred Years of Progress

  2007cited by this paper
• The quest for Eldorado: development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain.

  2006cited by this paper
• Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

  2006cited by this paper
• Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate.

  2006cited by this paper
• In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET.

  2005cited by this paper
• Nicotinic Acetylcholine Receptor Distribution in Alzheimer's Disease, Dementia with Lewy Bodies, Parkinson's Disease, and Vascular Dementia: In Vitro Binding Study Using 5-[125I]-A-85380

  2004cited by this paper
• The Comparative Pharmacology and Up-Regulation of Rat Neuronal Nicotinic Receptor Subtype Binding Sites Stably Expressed in Transfected Mammalian Cells

  2004cited by this paper
• Evaluation of 5‐(2‐(4‐pyridinyl)vinyl)‐6‐chloro‐3‐(1‐methyl‐2‐(S)‐pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors

  2004cited by this paper
• Rigid Body Registration

  2003cited by this paper
• Long‐lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys

  2002cited by this paper
• Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.

  2002cited by this paper
• Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia.

  2001cited by this paper
• Template Images for Nonhuman Primate Neuroimaging: 1. Baboon

  2001cited by this paper
• Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain

  2000cited by this paper
• Development of ligands for in vivo imaging of cerebral nicotinic receptors.

  2000cited by this paper
• Neuronal nicotinic receptors in the human brain.

  2000influential reference
• Imaging central nicotinic acetylcholine receptors in baboons with [18F]fluoro-A-85380.

  1999cited by this paper
• Neuronal nicotinic receptors : pharmacology and therapeutic opportunities

  1999cited by this paper
• Human neuronal nicotinic receptors.

  1997cited by this paper
• Multimodality image registration by maximization of mutual information

  1997cited by this paper
• Human Brain Function

  1997cited by this paper
• Benzodiazepine Receptor Quantification in vivo in Humans Using [11C]Flumazenil and PET: Application of the Steady-State Principle

  1995cited by this paper
• SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms.

  1994influential reference
• In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428

  1993cited by this paper
• Compartmental Analysis of [11C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography

  1991cited by this paper
• Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

  1990influential reference
• A new look at the statistical model identification

  1974influential reference

• Discovery of Fluorinated Ultrapotent Chemogenetic Ligands for PET Imaging and Neural Modulation in Nonhuman Primates.

  2026cites this paper
• Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography

  2023cites this paper
• A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research.

  2023cites this paper
• RO6807936 as a Novel PET Radiotracer for in Vitro and in Vivo Visualization and Quantification of BACE1 in the Rodent and Baboon Brain.

  2023cites this paper
• Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease

  2022cites this paper
• Preclinical and Clinical Aspects of Nicotinic Acetylcholine Receptor Imaging

  2020cites this paper
• PET Imaging of the α4β2* Nicotinic Acetylcholine Receptors in Alzheimer’s Disease

  2020cites this paper
• The relationship of varenicline agonism of α4β2 nicotinic acetylcholine receptors and nicotine-induced dopamine release in nicotine dependent humans.

  2019cites this paper
• Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy

  2019cites this paper
• Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

  2017cites this paper
• Imaging α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Baboons with [18F]XTRA, a Radioligand with Improved Specific Binding in Extra-Thalamic Regions

  2017cites this paper
• Advances in PET Imaging of Degenerative, Cerebrovascular, and Traumatic Causes of Dementia.

  2016cites this paper
• Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.

  2016cites this paper
• Development of Antidepressant Drugs Through Targeting α4β2-Nicotinic Acetylcholine Receptors

  2016cites this paper
• [(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

  2015cites this paper
• First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[18F]Flubatine

  2015cites this paper
• Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates.

  2015cites this paper
• Dose‐dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11C]ABP688 PET imaging

  2014cites this paper
• Radioligand imaging of α4β2* nicotinic acetylcholine receptors in Alzheimer's disease and Parkinson's disease.

  2014cites this paper
• 18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET

  2014cites this paper
• Neuroimaging in Alcohol and Drug Dependence

  2014cites this paper
• Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors.

  2014cites this paper
• Preclinical Aspects of Nicotinic Acetylcholine Receptor Imaging

  2014cites this paper
• Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque.

  2014cites this paper
• Neural nAChRs PET imaging probes

  2014cites this paper
• PET radiotracers for molecular imaging in dementia.

  2014cites this paper
• Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and biological evaluation of 3-(2-(S)-3,4-dehydropyrrolinyl methoxy)-5-(3'-¹⁸F-fluoropropyl)pyridine (¹⁸F-Nifrolene) using PET.

  2013cites this paper
• Radiosynthesis of racemic and enantiomerically pure (-)-[18F]flubatine--a promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors.

  2013cites this paper
• Covalent Conjugation of Fluorescence Probes to Nanoparticles for Signal Enhancement

  2013cites this paper
• PET Imaging of High-Affinity α4β2 Nicotinic Acetylcholine Receptors in Humans with 18F-AZAN, a Radioligand with Optimal Brain Kinetics

  2013cites this paper
• Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors.

  2013cites this paper
• Short- and long-term quantitation reproducibility of brain metabolites in the medial wall using proton echo planar spectroscopic imaging

  2012cites this paper
• PET Imaging of α4β2* Nicotinic Acetylcholine Receptors: Quantitative Analysis of 18F-Nifene Kinetics in the Nonhuman Primate

  2012cites this paper