New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Naunyn-Schmiedeberg's Archives of Pharmacology

• Publication date

  2003-01-23

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00210-002-0675-2PMID 12595951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of action of novel cardiotonic agents.

  2002cited by this paper
• 15 years of heart-failure trials: what have we learned?

  1998cited by this paper
• Toward the identification of the cardiac cGMP inhibited-phosphodiesterase catalytic site

  1998cited by this paper
• Inotropic agents. Synthesis and structure-activity relationships of new milrinone related cAMP PDE III inhibitors.

  1997cited by this paper
• A new milrinone analog: role of binding to A1 adenosine receptor in its positive inotropic effect on isolated guinea pig and rat atria.

  1997cited by this paper
• New inotropic agents: milrinone analogs.

  1997cited by this paper
• Mechanisms of plumbagin action on guinea pig isolated atria.

  1996cited by this paper
• Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.

  1996cited by this paper
• A pharmacological, crystallographic, and quantum chemical study of new inotropic agents.

  1993cited by this paper
• Antagonism towards endogenous adenosine and inhibition of cGI-PDE in the cardiac effects of amrinone, milrinone and related analogues.

  1992cited by this paper
• Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors.

  1992cited by this paper
• An analysis of the mechanism of the inotropic action of some milrinone analogues in guinea‐pig isolated atria

  1991cited by this paper
• Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.

  1991cited by this paper
• Involvement of purine compounds in the inotropic action of milrinone

  1990influential reference
• Properties of the inotropic response in rat papillary muscles to the dihydropyridine "Ca-channel activator" BAY K 8644.

  1988cited by this paper
• Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine.

  1988cited by this paper
• Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine

  1988cited by this paper
• Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.

  1987cited by this paper
• Reaction of 2‐dimethylaminomethylene‐1,3‐diones with dinucleophiles. VI. Synthesis of ethyl or methyl 1,5‐disubstituted 1H‐pyrazole‐4‐carboxylates

  1987cited by this paper
• Subclasses of Cyclic AMP‐Specific Phosphodiesterase in Left Ventricular Muscle and Their Involvement in Regulating Myocardial Contractility

  1987cited by this paper
• Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents.

  1986cited by this paper
• Biochemical mechanisms for the inotropic effect of the cardiotonic drug milrinone.

  1986influential reference
• Interaction of amrinone with endogenous adenosine in guinea‐pig atria

  1986cited by this paper
• Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle.

  1986cited by this paper
• Competitive inhibition of phosphodiesterase activity by amrinone: its implication in the cardiac effect of the drug.

  1984cited by this paper
• Amrinone

  1983cited by this paper
• Equilibrium calcium-calcium exchange in cardiac sarcolemmal vesicles.

  1983cited by this paper
• Isolated atrial myocytes: adenosine and acetylcholine increase potassium conductance.

  1983cited by this paper
• Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle.

  1982cited by this paper
• Principles of treatment of left ventricular failure.

  1982cited by this paper
• Involvement of cyclic AMP in the direct inotropic action of amrinone

  1981cited by this paper
• Combined vasodilator and inotropic therapy of heart failure: experimental and clinical concepts.

  1981cited by this paper
• Ligand: a versatile computerized approach for characterization of ligand-binding systems.

  1980cited by this paper
• Digitalis cardiotoxicity revisited.

  1980cited by this paper
• Comments on "cardiotonic activity of amrinone-win 40680 [5-amino-3-4'-bypyridin-6(1H)-one]".

  1980cited by this paper
• Correlation of cyclic AMP and cyclic GMP levels with changes in contractile force of dog ventricular myocardium during cholinergic antagonism of positive inotropic actions of histamine, glucagon, theophylline and papaverine.

  1979cited by this paper
• Cardiotonic Activity of Amrinone–Win 40680 [5‐Amino‐3,4f‐bipyridin‐6(lH)‐one]

  1979cited by this paper
• New cardiotonic agents: a search for digitalis substitute.

  1978cited by this paper
• Monovalent cation stimulation of Ca2+ uptake by cardiac membrane vesicles.

  1977cited by this paper
• Cyclic AMP and contractile activity in heart.

  1977cited by this paper
• Drugs and the heart muscle.

  1977influential reference
• Assay of cyclic nucleotide phosphodiesterases with radioactive substrates.

  1974cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper
• Drugs and heart muscle.

  1972cited by this paper
• Current concepts and treatment of digitalis toxicity.

  1971cited by this paper
• Letter to the editor

  1967cited by this paper
• The determination of enzyme inhibitor constants.

  1953influential reference
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor

  2020cites this paper
• Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies

  2013cites this paper
• Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

  2011cites this paper
• Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells.

  2010cites this paper
• Synthesis and Evaluation of Novel Iminosugars as Potential Male Contraceptive Agents; and the Chemistry of 2,3-Dihydropyridin-4-(1H)-ones and Related Enaminones in Multicomponent Reactions

  2010cites this paper
• Assessment of myocardial blood perfusion improved by CD151 in a pig myocardial infarction model

  2009cites this paper
• Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.

  2009cites this paper
• Quinolinedione nucleus as a novel scaffold for A1 and A2A adenosine receptor antagonists

  2008cites this paper
• Pyridazinone derivatives: design, synthesis, and in vitro vasorelaxant activity.

  2008cites this paper
• Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease

  2007cites this paper
• In Vitro Evidence That Carteolol Is a Nonconventional Partial Agonist of Guinea Pig Cardiac β1-Adrenoceptors: A Comparison with Xamoterol

  2005cites this paper
• Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone.

  2005cites this paper
• Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations.

  2004cites this paper
• Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone.

  2003cites this paper