Effect of Robo4 on Retinal Endothelial Permeability

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Current Eye Research

• Publication date

  2013-01-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/02713683.2012.738844PMID 23163536
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.

  2011cited by this paper
• Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

  2010cited by this paper
• Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

  2010cited by this paper
• The inhibition of advanced glycation end-products-induced retinal vascular permeability by silver nanoparticles.

  2010cited by this paper
• ADF/cofilin: a functional node in cell biology.

  2010cited by this paper
• Vascular Robo4 restricts proangiogenic VEGF signaling in breast

  2010cited by this paper
• Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

  2009cited by this paper
• Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation‐promoting factors

  2009cited by this paper
• ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.

  2009cited by this paper
• Expression of Robo4 in the fibrovascular membranes from patients with proliferative diabetic retinopathy and its role in RF/6A and RPE cells

  2009cited by this paper
• Robo1/robo4: different expression patterns in retinal development.

  2009cited by this paper
• Ins and outs of ADF/cofilin activity and regulation.

  2008cited by this paper
• Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

  2008cited by this paper
• Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

  2008cited by this paper
• Bradykinin increases blood–tumor barrier permeability by down‐regulating the expression levels of ZO‐1, occludin, and claudin‐5 and rearranging actin cytoskeleton

  2008cited by this paper
• Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis

  2008cited by this paper
• A Three-Kilobase Fragment of the Human Robo4 Promoter Directs Cell Type–Specific Expression in Endothelium

  2007cited by this paper
• LIM kinases: function, regulation and association with human disease

  2007cited by this paper
• Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics.

  2007cited by this paper
• Vascular permeability in ocular disease and the role of tight junctions

  2007cited by this paper
• Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells 
THIS ARTICLE HAS BEEN RETRACTED

  2006cited by this paper
• Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms*

  2006cited by this paper
• Signaling mechanisms regulating endothelial permeability.

  2006cited by this paper
• MAPKAPK‐2‐mediated LIM‐kinase activation is critical for VEGF‐induced actin remodeling and cell migration

  2006cited by this paper
• Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability in endothelial cells

  2006cited by this paper
• Critical role of actin in modulating BBB permeability.

  2005cited by this paper
• Endothelial F-actin Cytoskeleton in the Retinal Vasculature of Normal and Diabetic Rats

  2005cited by this paper
• Occludin: structure, function and regulation.

  2005cited by this paper
• Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration

  2005cited by this paper
• Magic roundabout, a tumor endothelial marker: expression and signaling.

  2005cited by this paper
• Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.

  2005cited by this paper
• The Neurofibromatosis Type 1 Gene Product Neurofibromin Enhances Cell Motility by Regulating Actin Filament Dynamics via the Rho-ROCK-LIMK2-Cofilin Pathway*

  2005cited by this paper
• Regulation of tight junctions and loss of barrier function in pathophysiology.

  2004cited by this paper
• Cellular mechanisms of blood-retinal barrier dysfunction in macular edema

  2004cited by this paper
• Robo4 is a vascular-specific receptor that inhibits endothelial migration.

  2003cited by this paper
• Polarised migration: cofilin holds the front.

  2003cited by this paper
• Cellular motility driven by assembly and disassembly of actin filaments.

  2003cited by this paper
• Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1.

  2002cited by this paper
• Rho GTPases in cell biology

  2002cited by this paper
• Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor.

  2002cited by this paper
• Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis.

  2002cited by this paper
• Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

  2002cited by this paper
• Mechanisms regulating endothelial cell barrier function.

  2000cited by this paper
• Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin.

  1999cited by this paper
• Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

  1998cited by this paper
• The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton*

  1998cited by this paper
• Occludin as a possible determinant of tight junction permeability in endothelial cells.

  1997cited by this paper
• Blood-retinal barrier breakdown in retinitis pigmentosa: light and electron microscopic immunolocalization.

  1995cited by this paper
• Regulation of vascular endothelial barrier function.

  1994cited by this paper
• Characterization of Early Stages of Diabetic Retinopathy: Importance of the Breakdown of the Blood-Retinal Barrier

  1993cited by this paper
• Iatrogenic choroidal neovascularization in sickle cell retinopathy.

  1986cited by this paper

• Vascular Leakage Prevention by Roundabout 4 under Pathological Conditions.

  2021cites this paper
• DS-7080a, a Selective Anti-ROBO4 Antibody, Shows Anti-Angiogenic Efficacy with Distinctly Different Profiles from Anti-VEGF Agents

  2020cites this paper
• MicroRNA-411 plays a protective role in diabetic retinopathy through targeted regulating Robo4.

  2019cites this paper
• Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.

  2018cites this paper
• Transcription factor SP1 mediates hyperglycemia-induced upregulation of roundabout4 in retinal microvascular endothelial cells.

  2017cites this paper
• Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.

  2016cites this paper
• Validation of RT-qPCR reference genes and determination of Robo4 expression levels in human retinal endothelial cells under hypoxia and/or hyperglycemia.

  2016cites this paper
• Expression and clinical significance of ROBO4/ARF6 signal pathway in renal glomerulus tissue of patients with diabetic kidney disease

  2016cites this paper
• Roundabout 4 Regulates Blood–Tumor Barrier Permeability Through the Modulation of ZO-1, Occludin, and Claudin-5 Expression

  2015cites this paper
• The role of actin-binding proteins in the control of endothelial barrier integrity

  2014cites this paper
• CLN3 Deficient Cells Display Defects in the ARF1-Cdc42 Pathway and Actin-Dependent Events

  2014cites this paper
• Raised Plasma Robo4 and Cardiac Surgery-Associated Acute Kidney Injury

  2014cites this paper
• Cell biological defects in juvenile neuronal ceroid lipofuscinosis

  2013cites this paper
• Enhanced expression of Robo4 ameliorates LPS-induced acute lung injury in mice

  2011cites this paper