du CRSN : le point sur la dépression , première partie Impact of substance P receptor antagonism on the serotonin and norepinephrine systems : relevance to the antidepressant / anxiolytic response

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• New goals in the treatment of depression: moving toward recovery.

  2015cited by this paper
• Frequency-dependence of serotonin autoreceptor but not α2-adrenoceptor inhibition of [3H]-serotonin release in rat hypothalamic slices

  2004cited by this paper
• Effects of chronic paroxetine treatment on dialysate serotonin in 5‐HT1B receptor knockout mice

  2003cited by this paper
• Substance P serum levels are increased in major depression: preliminary results.

  2003cited by this paper
• Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.

  2002cited by this paper
• Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.

  2002influential reference
• Neurokinins Activate Local Glutamatergic Inputs to Serotonergic Neurons of the Dorsal Raphe Nucleus

  2002cited by this paper
• Substance P (Neurokinin 1) Receptor Antagonists Enhance Dorsal Raphe Neuronal Activity

  2002cited by this paper
• Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801

  2002cited by this paper
• Neurokinin-1 receptors are decreased in major depressive disorder

  2002cited by this paper
• Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity.

  2001cited by this paper
• 5-Hydroxytryptamine (5-HT)1A Autoreceptor Adaptive Changes in Substance P (Neurokinin 1) Receptor Knock-Out Mice Mimic Antidepressant-Induced Desensitization

  2001cited by this paper
• Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.

  2001influential reference
• Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors

  2001cited by this paper
• Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.

  2001cited by this paper
• Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission.

  2001influential reference
• Selective blockade of neurokinin (NK)1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

  2001cited by this paper
• Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: a double immunofluorescence study in the rat.

  2000influential reference
• Increased Tonic Activation of Rat Forebrain 5-HT1A Receptors by Lithium Addition to Antidepressant Treatments

  2000cited by this paper
• Neurochemical and electrophysiological studies on the functional significance of burst firing in serotonergic neurons.

  2000cited by this paper
• Effect of neurokinin‐1 receptor antagonists on the function of 5‐HT and noradrenaline neurons

  2000cited by this paper
• Tryptophan depletion and depressive vulnerability.

  1999cited by this paper
• Serotonin and Drug-Induced Therapeutic Responses in Major Depression, Obsessive–Compulsive and Panic Disorders

  1999cited by this paper
• Serotonin and substance P co-exist in dorsal raphe neurons of the human brain.

  1999cited by this paper
• Distinct mechanism for antidepressant activity by blockade of central substance P receptors.

  1998cited by this paper
• Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.

  1996cited by this paper
• Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression.

  1996cited by this paper
• Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain.

  1996cited by this paper
• Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.

  1993cited by this paper
• Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist.

  1991cited by this paper
• Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry.

  1988cited by this paper
• Evidence for, and nature of, the tonic inhibitory influence of habenulointerpeduncular pathways upon cerebral dopaminergic transmission in the rat.

  1986influential reference
• Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides.

  1977cited by this paper
• Physiological evidence for habenula as major link between forebrain and midbrain raphe.

  1977cited by this paper
• Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine.

  1975cited by this paper

• Current drug targets for the treatment of depression

  2025cites this paper
• Substance P’s Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review

  2024cites this paper
• Neuropeptides in psychiatry

  2022cites this paper
• Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain—Clinical Observation Study

  2022cites this paper
• Multiple facets of serotonergic modulation.

  2021cites this paper
• Overlapping Chronic Pain and Depression: Pathophysiology and Management

  2018cites this paper
• Investigation of the effect of homocysteinylation of substance P on its binding to the NK1 receptor using molecular dynamics simulation

  2018cites this paper
• The Hypothalamic–Pituitary–Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress

  2018cites this paper
• Importancia de la sustancia P y su receptor NK-1R en el cáncer de tiroides

  2016cites this paper
• Cross-talk between 5-hydroxytryptamine and substance P in the melanogensis and apoptosis of B16F10 melanoma cells.

  2016cites this paper
• Unexplained Painful Physical Symptoms in Patients with Major Depressive Disorder: Prevalence, Pathophysiology and Management

  2016cites this paper
• Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors

  2015cites this paper
• Neuropeptides : Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders

  2015cites this paper
• Pain and Depression: A Neurobiological Perspective of Their Relationship

  2015cites this paper
• Predictive validity of the neurokinin-1 knockout mouse in research into Attention Deficit Hyperactivity Disorder

  2015cites this paper
• Wpływ escitalopramu, nortryptyliny i wenlafaksyny na objawy bólowe w depresji

  2014cites this paper
• CRITICAL REVIEW IN PHARMACEUTICAL SCIENCES

  2014cites this paper
• Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.

  2013cites this paper
• The Role of Neuropeptides in Suicidal Behavior: A Systematic Review

  2013cites this paper
• Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain

  2013cites this paper
• Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain

  2012cites this paper
• The drugs don’t work? antidepressants and the current and future pharmacological management of depression

  2012cites this paper
• Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse

  2012influential citation
• Imbalance between Th17 and Treg Cells May Play an Important Role in the Development of Chronic Unpredictable Mild Stress-Induced Depression in Mice

  2012cites this paper
• Oltre le monoamine al fine di sviluppare nuovi farmaci antidepressivi

  2012cites this paper
• Beyond monoamines towards the development of novel antidepressants

  2012cites this paper
• Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.

  2012cites this paper
• Could the underestimation of bipolarity obstruct the search for novel antidepressant drugs?

  2011cites this paper
• Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK1 and NK3 receptors

  2011cites this paper
• The pharmacological properties of antidepressants

  2010cites this paper
• S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine.

  2010cites this paper
• Classical Neurotransmitters and Neuropeptides Involved in Major Depression: a Review

  2010cites this paper
• Pathogenic involvement of neuropeptides in anxiety and depression.

  2010cites this paper
• The interface of pain and mood disturbances in the rheumatic diseases.

  2010cites this paper
• Plasma and cerebrospinal fluid substance P in post‐stroke patients with depression

  2009cites this paper
• Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization

  2009cites this paper
• Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder

  2009cites this paper
• Changements dans le circuit de la récompense suite à la bulbectomie olfactive : une nouvelle approche pour étudier des antidépresseurs

  2009cites this paper
• The relationship between fibromyalgia and major depressive disorder: a comprehensive review

  2008cites this paper
• Novel Drugs and Therapeutic Targets for Severe Mood Disorders

  2008cites this paper
• Recent advances in the neurobiology of anxiety disorders: Implications for novel therapeutics

  2008cites this paper
• Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 – 2006

  2007cites this paper
• Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release

  2007influential citation
• Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function.

  2007cites this paper
• Assessment of antidepressant and anxiolytic properties of NK1 antagonists and substance P in Wistar Kyoto rats.

  2007cites this paper
• Does the Heat Stress Affect the Neurons Development in Some Central Nervous System Regions of Albino Rat Newborns

  2007cites this paper
• Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission

  2007cites this paper
• Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test.

  2006cites this paper
• New approaches to antidepressant drug discovery: beyond monoamines

  2006cites this paper
• Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus

  2006cites this paper
• 20 Substance P and the Tachykinins

  2006cites this paper
• Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.

  2006cites this paper
• Neurokinin-1 receptor in the basolateral nuclear group of the canine amygdala--comparative study in normal and aggressive dogs.

  2006cites this paper
• NK1 receptor antagonists under investigation for the treatment of affective disorders

  2006cites this paper
• [Depression and pain: novel clinical, neurobiological and psychopharmacological data].

  2005cites this paper
• Antidepressant-like effects of agomelatine, melatonin and the NK1 receptor antagonist GR205171 in impulsive-related behaviour in rats

  2005cites this paper
• Strategies for producing faster acting antidepressants.

  2005cites this paper
• Activation of central neurokinin-1 receptors induces reinstatement of cocaine-seeking behavior.

  2005cites this paper
• The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms.

  2005cites this paper
• Mutagenesis and knockout models: NK1 and substance P.

  2005cites this paper
• Future Antidepressants

  2004cites this paper