Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg).

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of General Virology

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1099/vir.0.040287-0PMID 22422061
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo.

  2011cited by this paper
• A modified live PRRSV vaccine and the pathogenic parent strain induce regulatory T cells in pigs naturally infected with Mycoplasma hyopneumoniae.

  2011cited by this paper
• Nonstructural protein 1α subunit-based inhibition of NF-κB activation and suppression of interferon-β production by porcine reproductive and respiratory syndrome virus.

  2010cited by this paper
• Induction of inducible CD4+CD25+Foxp3+ regulatory T lymphocytes by porcine reproductive and respiratory syndrome virus (PRRSV).

  2010cited by this paper
• European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells.

  2010cited by this paper
• Taming PRRSV: revisiting the control strategies and vaccine design.

  2010cited by this paper
• Vaccine efficacy and immune response to swine influenza virus challenge in pigs infected with porcine reproductive and respiratory syndrome virus at the time of SIV vaccination.

  2009cited by this paper
• Modulations of phenotype and cytokine expression of porcine bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus.

  2009cited by this paper
• Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice

  2009cited by this paper
• Induction of T helper 3 regulatory cells by dendritic cells infected with porcine reproductive and respiratory syndrome virus.

  2009cited by this paper
• Detection of Foxp3 protein expression in porcine T lymphocytes.

  2008cited by this paper
• Characterization of interaction between porcine reproductive and respiratory syndrome virus and porcine dendritic cells.

  2008cited by this paper
• Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association.

  2008cited by this paper
• Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus

  2008influential reference
• Enhanced IL-10 production in response to hepatitis C virus proteins by peripheral blood mononuclear cells from human immunodeficiency virus-monoinfected individuals

  2008influential reference
• Impact of aboriginal ethnicity on HCV core‐induced IL‐10 synthesis: Interaction with IL‐10 gene polymorphisms

  2007influential reference
• Regulatory T cells and cancer.

  2007cited by this paper
• Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine.

  2006cited by this paper
• Effects of Porcine Reproductive and Respiratory Syndrome Virus-Infected Antigen-Presenting Cells on T Cell Activation and Antiviral Cytokine Production

  2006cited by this paper
• [A study of pulmonary inflammatory reaction induced by N-protein of SARS-CoV in rat models and effects of glucocorticoids on it].

  2005cited by this paper
• Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication

  2005cited by this paper
• The combination of PRRS virus and bacterial endotoxin as a model for multifactorial respiratory disease in pigs

  2004cited by this paper
• Role of neutralizing antibodies in PRRSV protective immunity.

  2004cited by this paper
• Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.

  2004cited by this paper
• Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination

  2004cited by this paper
• Genetics and geographical variation of porcine reproductive and respiratory syndrome virus (PRRSV) in Thailand.

  2004cited by this paper
• Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine

  2004cited by this paper
• Interleukin-10, Interleukin-12, and Interferon-γ Levels in the Respiratory Tract Following Mycoplasma hyopneumoniae and PRRSV Infection in Pigs

  2003cited by this paper
• Structure of the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus

  2003cited by this paper
• Hepatitis C Virus Core and Nonstructural Protein 3 Proteins Induce Pro- and Anti-inflammatory Cytokines and Inhibit Dendritic Cell Differentiation1

  2003cited by this paper
• Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination.

  2003cited by this paper
• Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus.

  2003cited by this paper
• Expression of interleukin-10 and interleukin-12 in piglets experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV).

  2003cited by this paper
• Upregulation of interleukin-10 gene expression in the leukocytes of pigs infected with porcine reproductive and respiratory syndrome virus.

  2003cited by this paper
• Immunological Responses of Swine to Porcine Reproductive and Respiratory Syndrome Virus Infection

  2002cited by this paper
• Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

  2001cited by this paper
• Interleukin-10 and the interleukin-10 receptor.

  2001cited by this paper
• Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae.

  2000cited by this paper
• Proinflammatory cytokines and viral respiratory disease in pigs.

  2000cited by this paper
• Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus

  2000cited by this paper
• Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development

  2000cited by this paper
• Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

  2000cited by this paper
• Pathogenesis of Porcine Reproductive and Respiratory Syndrome Virus-induced Increase in Susceptibility to Streptococcus suis Infection

  2000cited by this paper
• PRRSV, the virus.

  2000cited by this paper
• Effects of Low (Modified-live Virus Vaccine) and High (VR-2385)-Virulence Strains of Porcine Reproductive and Respiratory Syndrome Virus on Pulmonary Clearance of Copper Particles in Pigs

  1998cited by this paper
• Antigenic Structure of the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus

  1998influential reference
• The molecular biology of arteriviruses.

  1998cited by this paper
• Nidovirales: a new order comprising Coronaviridae and Arteriviridae.

  1997cited by this paper

• Paradigm shift: PRRSV-mediated active remodeling of the host immune system—From epigenetic domestication to functional hijacking

  2025cites this paper
• The Mechanism of Isatis Root Polysaccharides Inhibiting the Proliferation of PRRSV.

  2025cites this paper
• Analysis of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Interactome

  2025cites this paper
• An mRNA vaccine encoding multiple envelope glycoproteins of porcine reproductive and respiratory syndrome virus confers efficient protection against NADC30-like strains.

  2025cites this paper
• Research progress on the N protein of porcine reproductive and respiratory syndrome virus

  2024cites this paper
• Knock down of transforming growth factor beta improves expressions of co-stimulatory molecules, type I interferon-regulated genes, and pro-inflammatory cytokine in PRRSV-inoculated monocyte-derived macrophages

  2024cites this paper
• Enhanced antigen-specific CD8 T cells contribute to early protection against FMDV through swine DC vaccination

  2024cites this paper
• Type I and II interferons, transcription factors and major histocompatibility complexes were enhanced by knocking down the PRRSV-induced transforming growth factor beta in monocytes co-cultured with peripheral blood lymphocytes

  2024cites this paper
• The scene of lung pathology during PRRSV-1 infection

  2024cites this paper
• Coatsome-replicon vehicles: Self-replicating RNA vaccines against infectious diseases.

  2023cites this paper
• Codon Pair Deoptimization (CPD)-Attenuated PRRSV-1 Vaccination Exhibit Immunity to Virulent PRRSV Challenge in Pigs

  2023cites this paper
• Evasion strategies of porcine reproductive and respiratory syndrome virus

  2023influential citation
• TRIM26-mediated degradation of nucleocapsid protein limits porcine reproductive and respiratory syndrome virus-2 infection.

  2022cites this paper
• Structure and function of the porcine TAP protein and its inhibition by the viral immune evasion protein ICP47.

  2021cites this paper
• Activation of T-bet, FOXP3, and EOMES in Target Organs From Piglets Infected With the Virulent PRRSV-1 Lena Strain

  2021cites this paper
• Porcine reproductive and respiratory syndrome virus increases SOCS3 production via activation of p38/AP-1 signaling pathway to promote viral replication.

  2021cites this paper
• The Function of the PRRSV–Host Interactions and Their Effects on Viral Replication and Propagation in Antiviral Strategies

  2021cites this paper
• Swine Dendritic Cell Response to Porcine Reproductive and Respiratory Syndrome Virus: An Update

  2021cites this paper
• Fascinating Dendritic Cells—Sentinel Cells of the Immune System a Review

  2021cites this paper
• Identification of Virulence Associated Region during Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus during Attenuation In Vitro: Complex Question with Different Strain Backgrounds

  2021cites this paper
• Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

  2020cites this paper
• Emerging Swine Viruses

  2020cites this paper
• Antiviral Strategies of Chinese Herbal Medicine Against PRRSV Infection

  2020influential citation
• Nuclear localization signal in TRIM22 is essential for inhibition of type 2 porcine reproductive and respiratory syndrome virus replication in MARC-145 cells

  2019cites this paper
• Genetics and transcriptomics of host response to PRRS in nursery pigs

  2019cites this paper
• Porcine Reproductive and Respiratory Syndrome Virus Enhances Self-Replication via AP-1–Dependent Induction of SOCS1

  2019cites this paper
• Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)

  2019influential citation
• Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions

  2019cites this paper
• Interaction of PIAS1 with PRRS virus nucleocapsid protein mediates NF-κB activation and triggers proinflammatory mediators during viral infection

  2019cites this paper
• Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction

  2019cites this paper
• Induction of porcine reproductive and respiratory syndrome virus (PRRSV)-specific regulatory T lymphocytes (Treg) in the lungs and tracheobronchial lymph nodes of PRRSV-infected pigs.

  2018cites this paper
• Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83

  2018cites this paper
• Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections

  2018cites this paper
• CELLULAR AND MOLECULAR BASIS OF EQUINE ARTERITIS VIRUS PERSISTENT INFECTION IN THE STALLION REPRODUCTIVE TRACT: CHARACTERIZATION OF LOCAL HOST-PATHOGEN INTERACTIONS MEDIATING LONG-TERM VIRAL PERSISTENCE

  2018cites this paper
• A highly pathogenic porcine reproductive and respiratory syndrome virus type 1 (PRRSV-1) strongly modulates cellular innate and adaptive immune subsets upon experimental infection.

  2018cites this paper
• Interleukin-1 receptor antagonist: an early immunomodulatory cytokine induced by porcine reproductive and respiratory syndrome virus.

  2017cites this paper
• The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-κB and Sp1 Signaling Pathways

  2017cites this paper
• The integrity of PRRSV nucleocapsid protein is necessary for up-regulation of optimal interleukin-10 through NF-κB and p38 MAPK pathways in porcine alveolar macrophages.

  2017cites this paper
• Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus.

  2017influential citation
• The viral innate immune antagonism and an alternative vaccine design for PRRS virus

  2017influential citation
• Production of a novel Affimer based biosensor for the detection of porcine reproductive and respiratory syndrome virus nucleocapsid protein.

  2017influential citation
• Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein

  2017cites this paper
• Positive immunomodulatory effects of heterologous DNA vaccine- modified live vaccine, prime-boost immunization, against the highly-pathogenic PRRSV infection.

  2017cites this paper
• Equine Arteritis Virus Has Specific Tropism for Stromal Cells and CD8+ T and CD21+ B Lymphocytes but Not for Glandular Epithelium at the Primary Site of Persistent Infection in the Stallion Reproductive Tract

  2017cites this paper
• Design, development and experimental trialof a tailored cytotoxic T-cell vaccine againstPorcine Reproductive and RespiratorySyndrome Virus-2

  2017cites this paper
• Heterogeneity of swine lung macrophages inoculated by porcine reproductive and respiratory syndrome virus

  2016cites this paper
• Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System.

  2016cites this paper
• Transdermal delivery of plasmid encoding truncated nucleocapsid protein enhanced PRRSV-specific immune responses.

  2016cites this paper
• Generation of potent porcine monocyte-derived dendritic cells (MoDCs) by modified culture protocol.

  2016cites this paper
• The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I.

  2016cites this paper
• The Chinese highly pathogenic porcine reproductive and respiratory syndrome virus infection suppresses Th17 cells response in vivo.

  2016influential citation
• Mucosal Veterinary Vaccines

  2015cites this paper
• Host–pathogen interactions during porcine reproductive and respiratory syndrome virus 1 infection of piglets

  2015cites this paper
• Expression profile of Toll-like receptor mRNA in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.

  2015cites this paper
• Characterisation of the T cell response to the porcine reproductive and respiratory syndrome virus and its application towards the development of improved vaccines

  2015cites this paper
• An SH3 binding motif within the nucleocapsid protein of porcine reproductive and respiratory syndrome virus interacts with the host cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin.

  2015cites this paper
• The role of IL-10 in microbiome-associated immune modulation and disease tolerance.

  2015cites this paper
• The N-N non-covalent domain of the nucleocapsid protein of type 2 porcine reproductive and respiratory syndrome virus enhances induction of IL-10 expression.

  2015influential citation
• Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein

  2015cites this paper
• The 15N and 46R Residues of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Enhance Regulatory T Lymphocytes Proliferation

  2015cites this paper
• PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate

  2015cites this paper
• A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept.

  2015cites this paper
• ost – pathogen interactions during porcine reproductive and espiratory syndrome virus 1 infection of piglets rancisco

  2015cites this paper
• Regulation and evasion of antiviral immune responses by porcine reproductive and respiratory syndrome virus

  2014cites this paper
• GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity.

  2014cites this paper
• Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae

  2014cites this paper
• Sodium Tanshinone Iia Sulfonate Inhibits Porcine Reproductive and Respiratory Syndrome Virus via Suppressing N Gene Expression and Blocking Virus-Induced Apoptosis

  2014cites this paper
• Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

  2014cites this paper
• Molecular Characterization and Expression Analysis of miR-29a in Porcine Cells and Porcine Reproductive and Respiratory Syndrome Virus Infected Peripheral Blood Mononuclear Cells

  2014cites this paper
• Odpowiedü immunologiczna w przebiegu zaka¿eæ wirusem zespo‡u rozrodczo-oddechowego úwiæ

  2013cites this paper
• Molecular evolution of PRRSV in Europe: current state of play.

  2013cites this paper
• Plasmids expressing porcine interferon gamma up-regulate pro-inflammatory cytokine and co-stimulatory molecule expression which are suppressed by porcine reproductive and respiratory syndrome virus.

  2013cites this paper
• Urinary Trypsin Inhibitor Attenuated Inflammatory Response of Patients Undergoing Cardiopulmonary Bypass by Inducing Activated Treg Cells

  2013cites this paper
• Arterivirus molecular biology and pathogenesis.

  2013cites this paper
• Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-κB and p38 MAPK pathways in porcine alveolar macrophages.

  2013cites this paper
• Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?

  2012cites this paper
• Co-infection of porcine dendritic cells with porcine circovirus type 2a (PCV2a) and genotype II porcine reproductive and respiratory syndrome virus (PRRSV) induces CD4+CD25+FoxP3+ T cells in vitro

  2012cites this paper