Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP‐dependent Lon protease

Rats bearing the Zajdela hepatoma tumor and T3‐treated hypothyroid rats were used to study the role of protein degradation in the process of mitochondrial biogenesis. It was shown that the activity, protein and mRNA levels of the ATP‐dependent Lon protease increased in rapidly growing Zajdela hepatoma cells. The increase in the rate of mitochondrial biogenesis by thyroid hormone was similarly accompanied by enhanced expression of the Lon protease. The results imply that mitochondrial biogenesis in mammalian cells is, at least partially, regulated by the matrix Lon protease.

• Publication year

  1999

• Venue

  FEBS Letters

• Publication date

  1999-02-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-5793(99)00058-7PMID 10050756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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