Werner’s syndrome: An underdiagnosed disorder resembling premature aging

No abstract is available for this paper.

• Publication year

  1984

• Venue

  AGE

• Publication date

  1984-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF02432205
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• High prevalence of Werner's syndrome in Sardinia. Description of six patients and estimate of the gene frequency

  2004cited by this paper
• Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's syndrome

  2004cited by this paper
• Werner's syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations

  2004cited by this paper
• Fibroblast culture in Werner's syndrome

  2004cited by this paper
• Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

  2004cited by this paper
• [Werner's syndrome and endocrine disorders].

  2003cited by this paper
• Aging of cultured human skin fibroblasts.

  1997cited by this paper
• [Werner's syndrome].

  1983cited by this paper
• Letter to the Editor: Premature Aging of Fibroblasts from Patients with Duchenne Muscular Dystrophy

  1982cited by this paper
• Can We Learn about Aging from a Study of Werner's Syndrome?

  1982cited by this paper
• Urinary acidic glycosaminoglycans in Werner's syndrome

  1982cited by this paper
• Increased lability of triosephosphate isomerase in progeria and Werner's syndrome fibroblasts.

  1982cited by this paper
• Werner's Syndrome: Twenty‐four Cases with a Review of the Japanese Medical Literature

  1982cited by this paper
• Energy metabolism in cultured human fibroblasts during aging in vitro

  1982cited by this paper
• Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism.

  1981cited by this paper
• Patients with myotonic dystrophy, a possible segmental progeroid syndrome, and duchenne muscular dystrophy have fibroblasts with normal limits for in vitro lifespan and growth characteristics

  1981cited by this paper
• Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature

  1981cited by this paper
• Normal CuZn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in Werner's syndrome.

  1981cited by this paper
• Werner's syndrome.

  1980cited by this paper
• Protein synthetic errors do not increase during aging of cultured human fibroblasts.

  1980cited by this paper
• Fidelity of protein synthesis does not decline during aging of cultured human fibroblasts

  1980cited by this paper
• Experimental studies of premature ageing.

  1980cited by this paper
• Short communication lysosomal and mitochondrial heat labile enzymes in Werner's syndrome fibroblasts.

  1980cited by this paper
• Immunologic studies on Werner's syndrome.

  1980cited by this paper
• Metabolic studies in a case of Werner's syndrome.

  1979cited by this paper
• Subpopulations of Human T Lymphocytes

  1979cited by this paper
• Studies on age-related diseases in cultured skin fibroblasts.

  1979cited by this paper
• In vitro studies of age-associated diseases.

  1979cited by this paper
• Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome.

  1979cited by this paper
• Werner's syndrome: seven cases in one family.

  1979cited by this paper
• Excretion of glucose-containing oligosaccharides in urines of orthopedic patients.

  1979cited by this paper
• Deteriorating collagen synthesis and cell ultrastructure accompanying senescence of human normal and Werner's syndrome fibroblast cell strains.

  1979cited by this paper
• Cellular aging in Werner's syndrome: a unique phenotype?

  1979cited by this paper
• Werner's syndrome: in vivo and in vitro characteristics as a model of aging.

  1978cited by this paper
• Werner's syndrome: a model of premature aging?

  1978cited by this paper
• Werner's Syndrome: Analysis of 15 Cases with a Review of the Japanese Literature *

  1978cited by this paper
• Urinary excretion of macromolecular acidic glycosaminoglycans in Werner's syndrome.

  1978cited by this paper
• The effect of serum batch on the in vitro lifespans of cell cultures derived from old and young human donors.

  1978cited by this paper
• Collagen synthesis of cultured fibroblast from Werner's syndromes of premature aging

  1978cited by this paper
• Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging

  1978cited by this paper
• Genetic syndromes in man with potential relevance to the pathobiology of aging.

  1978cited by this paper
• Conservation of genes coding for proteins synthesized in human mitochondria

  1978cited by this paper
• A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture

  1977cited by this paper
• Progeria: A cell culture study and clinical report of familial incidence

  1977cited by this paper
• In vitro Aspects of Human Genetic Disorders which Feature Accelerated Aging

  1976cited by this paper
• Decreased proteolysis and increased amino acid efflux in aging human fibroblasts.

  1976cited by this paper
• Defective Proteins in Normal and Abnormal Human Fibroblasts during Aging in vitro1

  1976cited by this paper
• Increased procoagulant activity in cultured fibroblasts from progeria and Werner's syndromes of premature ageing

  1976cited by this paper
• Heat-labile enzymes in skin fibroblasts from subjects with progeria.

  1975cited by this paper
• Werner's syndrome as "hyaluronuria".

  1975cited by this paper
• Variegated translocation mosaicism in human skin fibroblast cultures.

  1975cited by this paper
• Heat-labile enzymes in Werner's syndrome fibroblasts

  1975cited by this paper
• Premature ageing and occurrance of altered enzyme in Werner's syndrome fibroblasts

  1974cited by this paper
• Alteration of fibroblast gene products in vitro from a subject with Werner's syndrome

  1974cited by this paper
• The biology of human aging.

  1973cited by this paper
• Replication Rate and Lifespan of Cultured Fibroblasts in Down's Syndrome 1

  1972cited by this paper
• Progeria: a cell culture study on aging.

  1971cited by this paper
• Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

  1970cited by this paper
• Lifespan of cultured cells in progeria.

  1969cited by this paper
• DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS

  1969cited by this paper
• The acid mucopolysaccharides in normal urine.

  1967cited by this paper
• A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

  1966cited by this paper
• CARE OF THE DYING.

  1965cited by this paper
• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

  1965cited by this paper
• The maintenance of the accuracy of protein synthesis and its relevance to ageing.

  1963cited by this paper
• The serial cultivation of human diploid cell strains.

  1961cited by this paper
• Werner’s Syndrome (Progeria of the Adult) and Rothmund’s Syndrome: Two Types of Closely Related Heredofamilial Atrophic Dermatoses with Juvenile Cataracts and Endocrine Features; A Critical Study with Five New Cases

  1945cited by this paper
• Über Katarakt in Verbindung mit Sklerodermie

  year unknowncited by this paper

• Human RECQ Helicase Pathogenic Variants, Population Variation and “Missing” Diseases

  2017cites this paper
• Absence of premature senescence in Werner's syndrome keratinocytes.

  2016cites this paper
• Speeding up the clock: The past, present and future of progeria

  2016cites this paper
• ‘…Re-written in the skin’ – Clues to skin biology and aging from inherited disease

  2015cites this paper
• Human RECQ helicases: roles in cancer, aging, and inherited disease

  2014cites this paper
• Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence

  2014cites this paper
• Microwave-assisted Synthesis of Inhibitors of MK2 for Targeting p38 MAP Kinase Signalling in Werner Syndrome Cells

  2014cites this paper
• p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes

  2012cites this paper
• Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund–Thomson syndrome

  2012cites this paper
• Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.

  2010cites this paper
• Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.

  2010cites this paper
• uman RECQ helicases : Roles in DNA metabolism , mutagenesis nd cancer biology

  2010cites this paper
• Werner’s syndrome: a quite rare disease for differential diagnosis of scleroderma

  2010cites this paper
• Physiological responses to genomic instability

  2010cites this paper
• Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts

  2010cites this paper
• Epigenetic Silencing of Progeroid Syndromes

  2010cites this paper
• Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.

  2010cites this paper
• Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology.

  2010cites this paper
• A case of atypical Werner syndrome without WRN gene mutations

  2009cites this paper
• Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts

  2009cites this paper
• Werner syndrome, telomeres, and stress signaling: implications for future therapies?

  2008cites this paper
• Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.

  2008cites this paper
• The Role of Cellular Senescence in Werner Syndrome

  2007cites this paper
• Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

  2007cites this paper
• Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

  2007cites this paper
• Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.

  2007cites this paper
• The spectrum of WRN mutations in Werner syndrome patients

  2006cites this paper
• Werner Syndrome as an Example of Inflamm-aging: Possible Therapeutic Opportunities for a Progeroid Syndrome?

  2006cites this paper
• Werner Syndrome as a Model of Human Aging

  2006cites this paper
• Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

  2005cites this paper
• Role of molecular chaperones in neurodegenerative disorders

  2005cites this paper
• EVALUACIÓN DE LA EXPRESIÓN DE WRN Y PAI-1 EN RATON NORMAL Y TRANSGENICO PARA WRN Y EL POSIBLE PAPEL DE WRN COMO FACTOR DE TRANSCRIPCIÓN DE PAI-1

  2004cites this paper
• What Can Progeroid Syndromes Tell Us About Human Aging?

  2004cites this paper
• Fibroblast clones from patients with Hutchinson-Gilford progeria can senesce despite the presence of telomerase.

  2004cites this paper
• Cytogenetic studies using various clastogens in two patients with Werner syndrome and control individuals

  2004cites this paper
• Werner syndrome protein--unwinding function to explain disease.

  2004cites this paper
• Replicative Senescence, Telomeres and Werner’s Syndrome

  2004cites this paper
• Absence of distinct dots in chromosomes of differentiated lymphocytes

  1996cites this paper
• Cloning of cDNAs with possible association with senescence and immortalization of human cells.

  1994cites this paper