New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Seminars in Immunopathology

• Publication date

  2013-08-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00281-013-0395-3PMID 23963494PMCID PMC3808126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood.

  2013cited by this paper
• Aryl Hydrocarbon Receptor (AHR)-Active Pharmaceuticals Are Selective AHR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells

  2012cited by this paper
• Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

  2012cited by this paper
• The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells.

  2012cited by this paper
• Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses

  2012cited by this paper
• Aryl Hydrocarbon Receptor-Mediated Induction of EBV Reactivation as a Risk Factor for Sjögren’s Syndrome

  2012cited by this paper
• Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns.

  2012cited by this paper
• Novel Cellular Targets of AhR Underlie Alterations in Neutrophilic Inflammation and Inducible Nitric Oxide Synthase Expression during Influenza Virus Infection

  2012influential reference
• Dendritic cells and influenza A virus infection

  2012cited by this paper
• Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection.

  2012cited by this paper
• Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection

  2011cited by this paper
• Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.

  2011cited by this paper
• Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

  2011cited by this paper
• Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy.

  2011cited by this paper
• Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's disease.

  2011cited by this paper
• Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response

  2011cited by this paper
• AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

  2011cited by this paper
• Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis

  2011cited by this paper
• Imbalanced pro- and anti-Th17 responses (IL-17/granulocyte colony-stimulating factor) predict fatal outcome in 2009 pandemic influenza

  2011cited by this paper
• Controlling Viral Immuno-Inflammatory Lesions by Modulating Aryl Hydrocarbon Receptor Signaling

  2011cited by this paper
• The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis

  2010cited by this paper
• Mammalian Per-Arnt-Sim proteins in environmental adaptation.

  2010cited by this paper
• Aryl hydrocarbon receptor activation reduces dendritic cell function during influenza virus infection.

  2010cited by this paper
• An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

  2010cited by this paper
• Suppression of Innate Immune Pathology by Regulatory T Cells during Influenza A Virus Infection of Immunodeficient Mice

  2010cited by this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs stable establishment of oral tolerance in mice.

  2010cited by this paper
• A Niche for Infectious Disease in Environmental Health: Rethinking the Toxicological Paradigm

  2010cited by this paper
• The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

  2010cited by this paper
• 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin modifies expression and nuclear/cytosolic localization of bovine herpesvirus 1 immediate‐early protein (bICP0) during infection

  2010cited by this paper
• Regulation of cellular and viral protein expression by the Epstein-Barr virus transcriptional regulator Zta: Implications for therapy of EBV associated tumors

  2009cited by this paper
• Beta-naphthoflavone causes an AhR-independent inhibition of invasion and intracellular multiplication of Listeria monocytogenes in murine hepatocytes.

  2009cited by this paper
• Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide

  2009cited by this paper
• Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes.

  2009cited by this paper
• Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

  2009cited by this paper
• The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

  2009cited by this paper
• Immunity to respiratory viruses.

  2009cited by this paper
• Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound.

  2008cited by this paper
• Aryl hydrocarbon receptor targets pathways extrinsic to bone marrow cells to enhance neutrophil recruitment during influenza virus infection.

  2008cited by this paper
• Identification of ah receptor agonists in soil of E-waste recycling sites from Taizhou area in China.

  2008cited by this paper
• The search for endogenous activators of the aryl hydrocarbon receptor.

  2008cited by this paper
• Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

  2008cited by this paper
• Severe PCDD/F and PBDD/F pollution in air around an electronic waste dismantling area in China.

  2007cited by this paper
• Innate immunity to respiratory viruses

  2007cited by this paper
• The Aryl Hydrocarbon Receptor Is Required for Optimal Resistance to Listeria monocytogenes Infection in Mice1

  2007cited by this paper
• Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells.

  2007influential reference
• Body loadings and health risk assessment of polychlorinated dibenzo-p-dioxins and dibenzofurans at an intensive electronic waste recycling site in China.

  2007cited by this paper
• Aryl Hydrocarbon Receptor Activation during Influenza Virus Infection Unveils a Novel Pathway of IFN-γ Production by Phagocytic Cells1

  2007cited by this paper
• Regulation of Transactivation Function of the Aryl Hydrocarbon Receptor by the Epstein-Barr Virus-encoded EBNA-3 Protein*

  2006influential reference
• 8-TETRACHLORODIBENZO-P-DIOXIN ( TCDD ) REDUCES LEISHMANIA MAJOR BURDENS IN C 57 BL / 6 MICE

  2006cited by this paper
• Dietary intake of dioxins and dioxin-like PCBs, due to the consumption of dairy products, fish/seafood and meat from Ismailia city, Egypt.

  2006cited by this paper
• Aryl Hydrocarbon Receptor Activation Impairs the Priming but Not the Recall of Influenza Virus-Specific CD8+ T Cells in the Lung1

  2006cited by this paper
• Protection against Lethal Challenge with Streptococcus pneumoniae Is Conferred by Aryl Hydrocarbon Receptor Activation but Is Not Associated with an Enhanced Inflammatory Response

  2006cited by this paper
• Reduced Antibody Responses to Vaccinations in Children Exposed to Polychlorinated Biphenyls

  2006cited by this paper
• 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.

  2006cited by this paper
• T‐cell memory and recall responses to respiratory virus infections

  2006cited by this paper
• The burden of pneumonia in children: an Asian perspective.

  2005cited by this paper
• Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus.

  2005cited by this paper
• Low level exposure to chemicals and immune system.

  2005cited by this paper
• Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells1

  2005cited by this paper
• CD4 T cell responses to influenza infection.

  2004cited by this paper
• Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik

  2004cited by this paper
• Activation of the aryl hydrocarbon receptor diminishes the memory response to homotypic influenza virus infection but does not impair host resistance.

  2004cited by this paper
• B cells under influence: transformation of B cells by Epstein–Barr virus

  2003cited by this paper
• Examining the relationship between impaired host resistance and altered immune function in mice treated with TCDD.

  2003cited by this paper
• 3‐Methylcholanthrene Activates Human Immunodeficiency Virus Type 1 Replication via Aryl Hydrocarbon Receptor

  2003cited by this paper
• Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.

  2003cited by this paper
• Fewer CTL, not enhanced NK cells, are sufficient for viral clearance from the lungs of immunocompromised mice.

  2003cited by this paper
• Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) renders influenza virus-specific CD8+ T cells hyporesponsive to antigen.

  2003cited by this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin is a possible activator of human cytomegalovirus replication in a human fibroblast cell line.

  2002cited by this paper
• Mortality in dioxin-exposed mice infected with influenza: mitochondrial toxicity (reye's-like syndrome) versus enhanced inflammation as the mode of action.

  2002cited by this paper
• Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice

  2002cited by this paper
• Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on trace elements, inflammation and viral clearance in the myocardium during coxsackievirus B3 infection in mice.

  2002cited by this paper
• Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment.

  2001cited by this paper
• Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression.

  2001cited by this paper
• Intake Of Dioxins and Related Compounds from Food in the U.S. Population

  2001cited by this paper
• Adipose tissue concentrations of dioxins and dibenzofurans, titers of antibodies to Epstein-Barr virus early antigen and the risk for non-Hodgkin lymphoma.

  2001cited by this paper
• Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses the humoral and cell-mediated immune responses to influenza A virus without affecting cytolytic activity in the lung.

  2000cited by this paper
• Epstein–Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen

  2000cited by this paper
• Ahr null alleles: distinctive or different?

  1998cited by this paper
• Dioxin activates human immunodeficiency virus-1 expression in chronically infected promonocytic U1 cells by enhancing NF-kappa B activity and production of tumor necrosis factor-alpha.

  1996cited by this paper
• Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

  1996cited by this paper
• Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza virus host resistance in mice.

  1996cited by this paper
• Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.

  1996cited by this paper
• Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1996cited by this paper
• Dioxin Activates Human Immunodeficiency Virus-1 Expression in Chronically Infected Promonocytic U1 Cells by Enhancing NF-κB Activity and Production of Tumor Necrosis Factor-α

  1996cited by this paper
• Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

  1995cited by this paper
• Host resistance to Trichinella spiralis infection in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

  1995cited by this paper
• Immunol. Cell Biol.

  1995cited by this paper
• Links between prolonged exposure to xenobiotics, increased incidence of hepatopathies, immunological disturbances and exacerbation of latent Epstein-Barr virus infections.

  1995cited by this paper
• Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme.

  1995cited by this paper
• Assessment of host resistance to Trichinella spiralis in mice following preinfection exposure to 2,3,7,8-TCDD.

  1994cited by this paper
• Coxsackievirus B3 infection alters the uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin into various tissues of the mouse.

  1994cited by this paper
• Stimulatory effect of the CYP1A1 inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin on the reproduction of HIV-1 in human lymphoid cell culture.

  1993cited by this paper
• Acute respiratory infections.

  1991cited by this paper
• Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1990cited by this paper
• Modulation of serum complement levels following exposure to polychlorinated dibenzo-p-dioxins.

  1986cited by this paper
• Immunosuppression in mice induced by dioxin (TCDD) in feed.

  1980cited by this paper
• Immunosuppression in mice induced by dioxin (TCDD) in feed.

  1980cited by this paper
• Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immune suppression and decreased resistance to infection: endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment.

  1978cited by this paper

• Schizophrenia as a Disorder of Biological Barriers: A Narrative Review and Potential Interventions.

  2026cites this paper
• Respiratory syncytial virus downregulates the airway aryl hydrocarbon receptor pathway: implication for the development of a novel therapeutic target.

  2025cites this paper
• In Vitro Evaluation of Aryl Hydrocarbon Receptor Involvement in Feline Coronavirus Infection

  2025cites this paper
• Using the Key Characteristics Framework to Unlock the Mysteries of Aryl Hydrocarbon Receptor-Mediated Effects on the Immune System.

  2025cites this paper
• Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

  2024cites this paper
• Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection.

  2024cites this paper
• Nutrition, gastrointestinal microorganisms and metabolites in mastitis occurrence and control

  2024cites this paper
• Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases

  2024cites this paper
• Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes

  2024cites this paper
• Commensal bacteria inhibit viral infections via a tryptophan metabolite

  2024cites this paper
• Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation

  2023cites this paper
• Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor

  2023cites this paper
• Photo‐Enhanced Oil Toxicity to Alcid Immune Function

  2023cites this paper
• AhR may be involved in Th17 cell differentiation in chronic hepatitis B

  2023cites this paper
• An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor

  2023cites this paper
• Evolutive emergence and divergence of an Ig regulatory node: An environmental sensor getting cues from the aryl hydrocarbon receptor?

  2023cites this paper
• Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

  2022cites this paper
• Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases

  2022cites this paper
• Canine Coronavirus Activates Aryl Hydrocarbon Receptor during In Vitro Infection

  2022cites this paper
• The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice

  2022cites this paper
• Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence

  2021cites this paper
• Targeting Aryl Hydrocarbon Receptor Signaling Enhances Type I Interferon-Independent Resistance to Herpes Simplex Virus

  2021cites this paper
• Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation

  2021cites this paper
• AHR signaling is induced by infection with coronaviruses

  2021cites this paper
• AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection

  2021influential citation
• Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

  2020cites this paper
• Rational Use of Fluoroquinolones and Prevention of the Interruption Risk in Nursing in the Process of Oral Medication

  2020cites this paper
• Developmental 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin exposure of either parent enhances the risk of necrotizing enterocolitis in neonatal mice

  2020cites this paper
• Aryl hydrocarbon receptor (AHR) functions: balancing opposing processes including inflammatory reactions.

  2020cites this paper
• A potential role for AHR in SARS-CoV-2 pathology

  2020cites this paper
• AHR is a Zika virus host factor and a candidate target for antiviral therapy

  2020cites this paper
• Aryl hydrocarbon receptor (AHR)-mediated inflammation and resolution: non-genomic and genomic signaling.

  2020cites this paper
• Aryl hydrocarbon receptor (AHR), integrating energy metabolism and microbial or obesity-mediated inflammation.

  2020cites this paper
• Aryl hydrocarbon receptor (AHR): From selected human target genes and crosstalk with transcription factors to multiple AHR functions.

  2019cites this paper
• Human AHR functions in vascular tissue: Pro‐ and anti‐inflammatory responses of AHR agonists in atherosclerosis

  2019cites this paper
• Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection

  2019cites this paper
• Therapeutic potential of aryl hydrocarbon receptor in autoimmunity

  2019cites this paper
• Does TCDD Exposure Alter β7-Integrin Expression on Mouse B Cells?

  2019cites this paper
• Genome-Wide Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during Influenza A Virus Infection

  2019cites this paper
• Paternal Environmental Toxicant Exposure and Risk of Adverse Pregnancy Outcomes

  2019cites this paper
• Environmental contaminant mixtures modulate in vitro influenza infection.

  2018cites this paper
• Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome

  2018cites this paper
• Immunotoxicology of Halogenated Aromatic Hydrocarbons

  2018cites this paper
• A Cell Proliferation and Inflammatory Signature Is Induced by Lawsonia intracellularis Infection in Swine

  2018cites this paper
• The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface

  2018cites this paper
• The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

  2018cites this paper
• From TCDD‐mediated toxicity to searches of physiologic AHR functions

  2018cites this paper
• Sex-Dependent Influence of Developmental Toxicant Exposure on Group B Streptococcus-Mediated Preterm Birth in a Murine Model

  2018cites this paper
• Is chronic AhR activation by rapidly metabolized ligands safe for the treatment of immune-mediated diseases?

  2017cites this paper
• Does Modification of the Large Intestinal Microbiome Contribute to the Anti-Inflammatory Activity of Fermentable Fiber?

  2017cites this paper
• Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options

  2017cites this paper
• 7,12-Dimethylbenz(a)anthracene-induced genotoxicity on bone marrow cells from mice phenotypically selected for low acute inflammatory response.

  2016cites this paper
• Influence of Early-Life Environmental Exposures on Immune Function Across the Life Span

  2016cites this paper
• Implications de la production de kynurénines par pseudomonas aeruginosa dans la relation hôte-pathogène

  2016cites this paper
• Environmental-mediated intestinal homeostasis in neonatal mice.

  2015cites this paper
• Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection.

  2015cites this paper
• Negative regulation of host innate antiviral signaling

  2015cites this paper
• Developmental Exposure of Mice to Dioxin Promotes Transgenerational Testicular Inflammation and an Increased Risk of Preterm Birth in Unexposed Mating Partners

  2014cites this paper
• Roles for the aryl hydrocarbon receptor in the immune response to Toxoplasma gondii

  2014cites this paper
• New insights into the role of the aryl hydrocarbon receptor in the function of CD11c+ cells during respiratory viral infection

  2014cites this paper