Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Toxicological Sciences

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/toxsci/kfr303PMID 22048644
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  1999cited by this paper
• Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury.

  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Mitochondrial membrane potential monitored by JC-1 dye.

  1995cited by this paper
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  1995cited by this paper
• Tyrosine kinase inhibition: an approach to drug development.

  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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