Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Endocrinology

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/EN.2007-0160PMID 17412805PMCID PMC2085235
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004influential reference
• cAMP Analog Mapping of Epac1 and cAMP Kinase

  2003cited by this paper
• Epac: a new cAMP target and new avenues in cAMP research

  2003cited by this paper
• The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras.

  2003cited by this paper
• The lutropin/choriogonadotropin receptor, a 2002 perspective.

  2002cited by this paper
• A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

  2002cited by this paper
• Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor.

  2002cited by this paper
• MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR.

  2002cited by this paper
• Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors.

  2002cited by this paper
• Acute signaling by the LH receptor is independent of protein kinase C activation.

  2002cited by this paper
• Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro.

  2002influential reference
• Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms.

  2001cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• The ERK Signaling Cascade Inhibits Gonadotropin-Stimulated Steroidogenesis

  2001cited by this paper
• Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice.

  2001cited by this paper
• Mammalian MAP kinase signalling cascades

  2001cited by this paper
• Differentiation of the adult Leydig cell population in the postnatal testis.

  2001cited by this paper
• Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene.

  2001cited by this paper
• Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice.

  2001cited by this paper
• Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

  2000cited by this paper
• Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.

  2000cited by this paper
• Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex.

  2000cited by this paper
• Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor.

  1999cited by this paper
• Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.

  1999cited by this paper
• Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.

  1998cited by this paper
• Suppression of Gonadotropins Inhibits Gonadal Tumorigenesis in Mice Transgenic for the Mouse Inhibin α-Subunit Promoter/Simian Virus 40 T-Antigen Fusion Gene.

  1997cited by this paper
• Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.

  1997cited by this paper
• Molecular mechanisms of reappearance of luteinizing hormone receptor expression and function in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate.

  1997cited by this paper
• Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development.

  1997cited by this paper
• Activation of mitogen-activated protein kinases by gonadotropins and cyclic adenosine 5'-monophosphates in porcine granulosa cells.

  1996cited by this paper
• Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice.

  1996cited by this paper
• Differentiation of adult Leydig cells.

  1995influential reference
• Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

  1995cited by this paper
• Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism

  1994cited by this paper
• Leydig cell hyperplasia and adenomas in mice treated with finasteride, a 5 alpha-reductase inhibitor: a possible mechanism.

  1994cited by this paper
• Growth factor requirements for DNA synthesis by Leydig cells from the immature rat.

  1992influential reference
• Steroidogenesis-inducing protein promotes deoxyribonucleic acid synthesis in Leydig cells from immature rats.

  1992influential reference
• Interleukin-1 stimulates deoxyribonucleic acid synthesis in immature rat Leydig cells in vitro.

  1992cited by this paper
• Developmental changes in levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells.

  1992cited by this paper
• Differentiation of Leydig cell precursors in vitro: a role for androgen.

  1990cited by this paper
• Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate (EDS) can take place in the absence of LH.

  1989cited by this paper
• The regulation of the proliferation and differentiation of rat Leydig cell precursor cells after EDS administration or daily HCG treatment.

  1988cited by this paper
• Repopulation of Leydig cells in mature rats after selective destruction of the existent Leydig cells with ethylene dimethane sulfonate is dependent on luteinizing hormone and not follicle-stimulating hormone.

  1986cited by this paper
• Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses.

  1981cited by this paper
• Increase in Leydig cell number in testes of adult rats treated chronically with an excess of human chorionic gonadotropin.

  1980cited by this paper
• Epidermal growth factor.

  1979cited by this paper
• Human epidermal growth factor and the proliferation of human fibroblasts

  1976cited by this paper
• Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity.

  1975cited by this paper
• Epidermal growth factor

  1972cited by this paper

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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
• Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders [Review].

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Chapter 16 – Hormone Signaling in the Testis

  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Luteinizing hormone and human chorionic gonadotropin: origins of difference.

  2014cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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