Drugs acting on imidazoline receptors: a review of their pharmacology, their use in blood pressure control and their potential interest in cardioprotection.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Drugs

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 10595861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of moxonidine on urinary electrolyte excretion and renal haemodynamics in man

  2004cited by this paper
• Crossover comparison of moxonidine and clonidine in mild to moderate hypertension

  2004cited by this paper
• Participation of Imidazoline Receptors and Alpha2−‐Adrenoceptors in the Central Hypotensive Effects of Imidazoline‐Like Drugs

  1999cited by this paper
• Identification of human I1 receptors and their relationship to alpha 2-adrenoceptors.

  1999cited by this paper
• Chronic sympathetic suppression in the treatment of chronic congestive heart failure.

  1998cited by this paper
• Site and receptors involved in the sympathoinhibitory actions of rilmenidine.

  1998cited by this paper
• Catecholamines and their blockade in congestive heart failure.

  1998cited by this paper
• Evidence for the Existence of Imidazoline‐Specific Binding Sites in Synaptosomal Plasma Membranes of the Bovine Brainstem

  1998cited by this paper
• Regression of left ventricular hypertrophy in hypertensive patients after 1 year of treatment with rilmenidine: a double-blind, randomized, controlled (versus nifedipine) study.

  1998cited by this paper
• Complementary antihypertensive action of rilmenidine on the pressure-natriuresis relationship and sodium preference in spontaneously hypertensive rats.

  1998cited by this paper
• Preventive effect of rilmenidine on the occurrence of neurogenic ventricular arrhythmias in rabbits.

  1998cited by this paper
• Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera.

  1998cited by this paper
• Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure.

  1998cited by this paper
• Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?

  1997cited by this paper
• Imidazoline receptors.

  1997cited by this paper
• Activation of phosphatidylcholine-selective phospholipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla.

  1997cited by this paper
• Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild-to-moderate essential hypertension.

  1997cited by this paper
• The I1-imidazoline-binding site is a functional receptor mediating vasodepression via the ventral medulla.

  1997cited by this paper
• Moxonidine inhibits Na+/H+ exchange in proximal tubule cells and cortical collecting duct.

  1997cited by this paper
• Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure.

  1997cited by this paper
• The I1‐imidazoline receptor: from binding site to therapeutic target in cardiovascular disease

  1997cited by this paper
• Localization of the imidazoline binding domain on monoamine oxidase B.

  1997cited by this paper
• Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

  1996cited by this paper
• Inhibition of centrally induced ventricular arrhythmias by rilmenidine and idazoxan in rabbits

  1996cited by this paper
• Imidazoline receptors and their endogenous ligands.

  1996cited by this paper
• I2-imidazoline binding sites: relationship with different monoamine oxidase domains and identification of histidine residues mediating ligand binding regulation by H+1.

  1996cited by this paper
• Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits.

  1996cited by this paper
• Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes.

  1996cited by this paper
• Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

  1996cited by this paper
• Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine

  1996cited by this paper
• Autonomic nervous system and sudden cardiac death.

  1996cited by this paper
• Comparative Effects of Rilmenidine and Atenolol on Tests of Autonomic Function and Mental and Dynamic Exercise in Patients with Essential Hypertension

  1995cited by this paper
• Suppressing sympathetic activation in congestive heart failure. A new therapeutic strategy.

  1995cited by this paper
• I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling.

  1995cited by this paper
• Rilmenidine in Patients with Left Ventricular Hypertrophy: Beyond the Reduction of Left Ventricular Mass

  1995cited by this paper
• Involvement of alpha 2-adrenoceptors in the cardiovascular effects of moxonidine.

  1995cited by this paper
• Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion.

  1994cited by this paper
• Moxonidine and hydrochlorothiazide in combination: a synergistic antihypertensive effect.

  1994cited by this paper
• Twenty-four-hour blood pressure profiles in patients with mild-to-moderate hypertension: moxonidine versus captopril.

  1994cited by this paper
• Agmatine: an endogenous clonidine-displacing substance in the brain.

  1994cited by this paper
• Identification, localization and functional analysis of imidazoline and alpha adrenergic receptors in canine prostate.

  1994cited by this paper
• Rilmenidine‐Induced Hypotension in Conscious Rabbits Involves Imidazoline‐Preferring sReceptors

  1994cited by this paper
• [Moxonidine vs. captopril in minor to intermediate hypertension. Double-blind study of effectiveness and tolerance].

  1993cited by this paper
• Renal effects of rilmenidine in anesthetized rats: importance of renal nerves.

  1993cited by this paper
• Mediation of the hypotensive action of systemic clonidine in the rat by alpha 2-adrenoceptors.

  1993cited by this paper
• Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites.

  1993cited by this paper
• Sympathoinhibitory Action of Rilmenidine in Conscious Sinoaortically Denervated Rats

  1993cited by this paper
• Regression of left ventricular hypertrophy.

  1992cited by this paper
• A comparison of the haemodynamic and behavioural effects of moxonidine and clonidine in normotensive subjects.

  1992cited by this paper
• The effects of rilmenidine on tests of autonomic function in humans

  1992cited by this paper
• Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors.

  1991cited by this paper
• Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells.

  1991cited by this paper
• Effects of Swim Training Alone and in Combination with Clonidine and Rilmenidine on Blood Pressure, Plasma Electrolytes, Vasopressin, and Renin Activity in Spontaneously Hypertensive Rats

  1990cited by this paper
• Effect of imidazolines on Na+ transport and intracellular pH in renal proximal tubule cells.

  1990cited by this paper
• [Long-term experiences with moxonidine, a new antihypertensive agent].

  1990cited by this paper
• Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.

  1990cited by this paper
• Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit

  1990cited by this paper
• [Multicenter, double-blind study comparing rilmenidine 1 mg and hydrochlorothiazide 25 mg in 244 patients].

  1989cited by this paper
• Acceptability of rilmenidine and long-term surveillance of plasma concentrations in hypertensive patients with renal insufficiency.

  1989cited by this paper
• Rilmenidine and vigilance. Review of clinical studies.

  1989cited by this paper
• Rilmenidine selectivity for imidazoline receptors in human brain.

  1989cited by this paper
• Antihypertensive drugs and baroreflex sensitivity. Effects of rilmenidine.

  1989cited by this paper
• Correlation between the inhibitory effect on catecholaminergic ventrolateral medullary neurons and the hypotension evoked by clonidine: a voltammetric approach.

  1989cited by this paper
• Effort blood pressure control in the course of antihypertensive treatment.

  1989cited by this paper
• Treatment of systemic hypertension in insulin-treated diabetes mellitus with rilmenidine.

  1988cited by this paper
• A multicenter double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients.

  1988cited by this paper
• Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats.

  1988cited by this paper
• Dose and concentration-effect relations for rilmenidine.

  1988cited by this paper
• Antihypertensive efficacy and acceptability of rilmenidine in elderly hypertensive patients.

  1988cited by this paper
• Efficacy and safety of rilmenidine for arterial hypertension.

  1988cited by this paper
• Efficacy and acceptability of rilmenidine for mild to moderate systemic hypertension.

  1988cited by this paper
• Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats.

  1988cited by this paper
• Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha 1- and alpha 2-adrenoceptors affect sleep and arousal mechanisms.

  1987cited by this paper
• Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models.

  1986cited by this paper
• Pharmacological properties of (N-dicyclopropylmethyl) amino-2-oxazoline (S 3341), an alpha-2 adrenoceptor agonist.

  1985cited by this paper
• Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines.

  1984cited by this paper
• Isolation and partial purification of a clonidine-displacing endogenous brain substance.

  1984cited by this paper
• The nucleus reticularis lateralis: a region highly sensitive to clonidine.

  1981cited by this paper
• Clonidine withdrawal in hypertension. Changes in blood-pressure and plasma and urinary noradrenaline.

  1977cited by this paper

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  2023cites this paper
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• Relative Importance of Rostral Ventrolateral Medulla in Sympathoinhibitory Action of Rilmenidine in Conscious and Anesthetized Rabbits

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• [Comparison of the antihypertensive efficacy of and tolerance to 2 imidazoline receptor agonists: moxonidine and rilmenidine in monotherapy].

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• Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex

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• Moxonidine: Clinical Profile

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• Effect of moxonidine on left ventricular hypertrophy in hypertensive patients

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• Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity.

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• Journal of Clinical and Basic Cardiology

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