Characterization of canine osteosarcoma by array comparative genomic hybridization and RT‐qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gcc.20908PMID 21837709
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Osteosarcoma incidence and survival rates from 1973 to 2004

  2009influential reference
• met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre‐clinical model of human osteosarcoma

  2009cited by this paper
• Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre‐chemotherapeutic osteosarcoma cell line (OS1)

  2009cited by this paper
• Mammary tumorigenesis through LPA receptor signaling.

  2009cited by this paper
• Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

  2009cited by this paper
• Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

  2009influential reference
• Impaired cell cycle regulation of the osteoblast‐related heterodimeric transcription factor Runx2‐Cbfβ in osteosarcoma cells

  2009influential reference
• Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

  2009cited by this paper
• ‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors

  2009influential reference
• International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons

  2009cited by this paper
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  2009cited by this paper
• Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor

  2009influential reference
• Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

  2009influential reference
• Osteosarcoma Development and Stem Cell Differentiation

  2008influential reference
• A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

  2008cited by this paper
• High-resolution array CGH clarifies events occurring on 8p in carcinogenesis

  2008cited by this paper
• Cell Cycle Regulator Gene CDC5L, a Potential Target for 6p12-p21 Amplicon in Osteosarcoma

  2008cited by this paper
• TP53 gene mutations in canine osteosarcoma.

  2008influential reference
• A review of clinical and molecular prognostic factors in osteosarcoma

  2008cited by this paper
• Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH

  2008influential reference
• Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

  2008cited by this paper
• A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog.

  2007cited by this paper
• Clinicopathological relevance of tumour grading in canine osteosarcoma.

  2007cited by this paper
• Cooperation between Myc and YY1 provides novel silencing transcriptional targets of α3β1-integrin in tumour cells

  2007cited by this paper
• AutoGRAPH: an interactive web server for automating and visualizing comparative genome maps

  2007cited by this paper
• The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

  2007cited by this paper
• Osteosarcoma and chondrosarcoma: new signaling pathways as targets for novel therapeutic interventions.

  2007cited by this paper
• Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells.

  2007cited by this paper
• Comparative Aspects of Osteosarcoma

  2006cited by this paper
• An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage–fusion–bridge cycle events in osteosarcoma

  2005cited by this paper
• Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors.

  2005cited by this paper
• Genome sequence, comparative analysis and haplotype structure of the domestic dog

  2005cited by this paper
• Oncogenic potential of the RUNX gene family: ‘Overview’

  2004cited by this paper
• Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma

  2004influential reference
• Combined spectral karyotyping, multicolor banding, and microarray comparative genomic hybridization analysis provides a detailed characterization of complex structural chromosomal rearrangements associated with gene amplification in the osteosarcoma cell line MG-63.

  2004cited by this paper
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  2004cited by this paper
• High‐resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays

  2003cited by this paper
• Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping.

  2003cited by this paper
• The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

  2003cited by this paper
• Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas

  2003cited by this paper
• Chromosomal Breakpoint Detection in Human Cancer

  2003influential reference
• Prognostic Significance of a New Histologic Grading System for Canine Osteosarcoma

  2002influential reference
• Tumor Suppressor PTEN is Mutated in Canine Osteosarcoma Cell Lines and Tumors

  2002influential reference
• Overexpression of the Sis Oncogene in a Canine Osteosarcoma Cell Line

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma.

  2000cited by this paper
• Inactivation of p53 and Retinoblastoma Family Pathways in Canine Osteosarcoma Cell Lines

  2000cited by this paper
• FISH mapping and identification of canine chromosomes.

  1999cited by this paper
• DNA sequence copy number increase at 8q: A potential new prognostic marker in high‐grade osteosarcoma

  1999cited by this paper
• Comparative genomic hybridization of low-grade central osteosarcoma.

  1998cited by this paper
• C-myc and c-fos in Human Osteosarcoma: Prognostic Value of mRNA and Protein Expression

  1998cited by this paper
• Isolation of osteosarcoma‐associated amplified DNA sequences using representational difference analysis

  1997cited by this paper
• Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature.

  1997cited by this paper
• Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma.

  1996cited by this paper
• A simulation study of the number of events per variable in logistic regression analysis.

  1996cited by this paper
• Small Animal Clinical Oncology

  1996cited by this paper
• Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization.

  1995cited by this paper
• Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

  1995cited by this paper
• Comparative aspects of osteosarcoma. Dog versus man.

  1991cited by this paper
• Open Access Research Article Expression Analysis of Genes Associated with Human Osteosarcoma Tumors Shows Correlation of Runx2 Overexpression with Poor Response to Chemotherapy

  year unknowninfluential reference

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  2023cites this paper
• Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans

  2023cites this paper
• Potential Promises and Perils of Human Biological Treatments for Immunotherapy in Veterinary Oncology

  2023cites this paper
• Establishment and Characterization of Cell Lines from Canine Metastatic Osteosarcoma

  2023cites this paper
• Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer

  2023cites this paper
• Immunohistochemical expression of proliferation markers in canine osteosarcoma

  2022cites this paper
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  2022cites this paper
• Sarcomas of Bone and Soft Tissues in Children and Adolescents

  2021cites this paper
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  2021cites this paper
• Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

  2021cites this paper
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  2021cites this paper
• Improving human cancer therapy through the evaluation of pet dogs

  2020cites this paper
• Bioinformatics for animal diseases: focused to major diseases and cancer

  2020cites this paper
• Cytogenetics

  2020cites this paper
• The Etiology of Cancer

  2020cites this paper
• Improving human cancer therapy through the evaluation of pet dogs

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
• Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

  2017cites this paper
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  2017cites this paper
• Dog Models of Naturally Occurring Cancer

  2016cites this paper
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  2016cites this paper
• Effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN

  2015influential citation
• Domestic dogs and cancer research: a breed-based genomics approach.

  2014cites this paper
• Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.

  2014cites this paper
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  2014cites this paper
• Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy

  2014cites this paper
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  2014cites this paper
• Genomische Aberrationen in caninen Mammakarzinomen und deren Nachweis in zellfreier plasmatischer DNA

  2014cites this paper
• Array comparative genomic hybridization in osteosarcoma.

  2013cites this paper
• Breed-Predispositions to Cancer in Pedigree Dogs

  2013cites this paper
• Genome Aberrations in Canine Mammary Carcinomas and Their Detection in Cell-Free Plasma DNA

  2013cites this paper
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• Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

  2013cites this paper
• Tumors of the Skeletal System

  2012cites this paper
• A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations.

  2012cites this paper
• Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs.

  2012cites this paper
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  2012cites this paper
• Genetic characterization of dogs via chromosomal analysis and array-based comparative genomic hybridization (aCGH)

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• Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

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  2011cites this paper