Functional Rescue of β1‐Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2009-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1600-0854.2009.00932.xPMID 19515093PMCID PMC2755524
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Pharmacological chaperone action on G-protein-coupled receptors.

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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis.

  2003cited by this paper
• ER transport signals and trafficking of potassium channels and receptors.

  2002cited by this paper
• Lysine 270 in the third intracellular domain of the oxytocin receptor is an important determinant for G alpha(q) coupling specificity.

  2002cited by this paper
• Structural clusters of evolutionary trace residues are statistically significant and common in proteins.

  2002cited by this paper
• Evolutionary predictions of binding surfaces and interactions.

  2002cited by this paper
• Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer.

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  2002cited by this paper
• Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer*

  2002influential reference
• A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane.

  2001cited by this paper
• Prediction and confirmation of a site critical for effector regulation of RGS domain activity

  2001cited by this paper
• Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants.

  2000cited by this paper
• Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine.

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• Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor*

  2000cited by this paper
• Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.

  2000cited by this paper
• GABAB receptors - the first 7TM heterodimers.

  1999cited by this paper
• Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding.

  1998cited by this paper
• RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

  1998cited by this paper
• Association of gonadotropin receptor precursors with the protein folding chaperone calnexin.

  1998cited by this paper
• Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits.

  1997cited by this paper
• An evolutionary trace method defines binding surfaces common to protein families.

  1996cited by this paper
• A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation*

  1996cited by this paper
• Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin

  1996cited by this paper
• The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin.

  1994cited by this paper
• Primary structure of the Aequorea victoria green-fluorescent protein.

  1992cited by this paper
• Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label.

  1985cited by this paper
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• Carvedilol Prevents Redox Inactivation of Cardiomyocyte Β1-Adrenergic Receptors

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• Glycosylation and dimerization of the human δ-opioid receptor polymorphic variants

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• [Pharmacological chaperones: a potential therapeutic treatment for conformational diseases].

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