The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formation with cell surface hGH receptor and hGH-binding protein circulating in human plasma.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Molecular Endocrinology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/MEND.12.1.0054PMID 9440818
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Novel assays based on human growth hormone receptor as alternatives to the rat weight gain bioassay for recombinant human growth hormone.

  1996influential reference
• A Growth Hormone Agonist Produced by Targeted Mutagenesis at Binding Site 1.

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• Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling.

  1995cited by this paper
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  1992influential reference
• Growth hormone (GH) binding protein and GH interactions in vivo in the guinea pig.

  1992cited by this paper
• Rational design of potent antagonists to the human growth hormone receptor.

  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.

  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
• Growth hormone receptor and serum binding protein: purification, cloning and expression

  1987cited by this paper
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  1981cited by this paper
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  1980cited by this paper
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  1978cited by this paper
• Continuous cultures of fused cells secreting antibody of predefined specificity

  1975cited by this paper
• The interpretation of protein structures: estimation of static accessibility.

  1971influential reference
• The release of enzymes by osmotic shock from Escherichia coli in exponential phase.

  1966cited by this paper
• THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

  1949cited by this paper

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