Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein–Barr virus

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2012-04-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1118078109PMID 22493268PMCID PMC3340099
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes

  2022cited by this paper
• Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

  2011cited by this paper
• A model for analysis of the yield and the level of clustering of radiation-induced DNA-strand breaks in hydrated plasmids.

  2011cited by this paper
• PARP inhibitors in cancer therapy: promise, progress, and puzzles.

  2011cited by this paper
• Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

  2011cited by this paper
• Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.

  2011cited by this paper
• MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.

  2011cited by this paper
• Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival.

  2011cited by this paper
• Characterizing resection at random and unique chromosome double-strand breaks and telomere ends.

  2011cited by this paper
• Iniparib plus chemotherapy in metastatic triple-negative breast cancer.

  2011cited by this paper
• Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.

  2010cited by this paper
• ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors

  2010cited by this paper
• Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial.

  2010cited by this paper
• The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

  2010cited by this paper
• Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

  2010cited by this paper
• The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

  2010cited by this paper
• Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial.

  2010cited by this paper
• Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

  2010cited by this paper
• PARP inhibition: PARP1 and beyond

  2010cited by this paper
• The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

  2010cited by this paper
• Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.

  2009cited by this paper
• PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination

  2009cited by this paper
• RAD50 Is Required for Efficient Initiation of Resection and Recombinational Repair at Random, γ-Induced Double-Strand Break Ends

  2009cited by this paper
• Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

  2009cited by this paper
• Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis

  2008cited by this paper
• The comet assay: topical issues.

  2008cited by this paper
• PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

  2008cited by this paper
• Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.

  2008cited by this paper
• Potential use of the comet assay in the clinical management of cancer.

  2008cited by this paper
• High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

  2008cited by this paper
• The Transition of Closely Opposed Lesions to Double-Strand Breaks during Long-Patch Base Excision Repair Is Prevented by the Coordinated Action of DNA Polymerase δ and Rad27/Fen1

  2008cited by this paper
• Targeted therapy for cancer using PARP inhibitors.

  2008cited by this paper
• Mammalian single-strand break repair: mechanisms and links with chromatin.

  2007cited by this paper
• Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology

  2007cited by this paper
• Poly(ADP-ribose): novel functions for an old molecule

  2006cited by this paper
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

  2005influential reference
• Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

  2005influential reference
• Poly(ADP‐ribose) polymerase‐1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts

  2005cited by this paper
• Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation‐induced DNA base damage

  2004cited by this paper
• Radiation Sensitivity, H2AX Phosphorylation, and Kinetics of Repair of DNA Strand Breaks in Irradiated Cervical Cancer Cell Lines

  2004cited by this paper
• Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

  2004cited by this paper
• The comet assay for DNA damage and repair

  2004cited by this paper
• BRCA1 and BRCA2: 1994 and beyond

  2004cited by this paper
• BLM helicase‐dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

  2003cited by this paper
• DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair

  2002cited by this paper
• Effect of hydration on the induction of strand breaks and base lesions in plasmid DNA films by gamma-radiation.

  2002cited by this paper
• Base excision repair processing of radiation-induced clustered DNA lesions.

  2001cited by this paper
• The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway

  2001cited by this paper
• Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53

  2000cited by this paper
• Influence of radiation quality on the yield of DNA strand breaks in SV40 DNA irradiated in solution.

  1999cited by this paper
• Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

  1999cited by this paper
• The role of DNA single- and double-strand breaks in cell killing by ionizing radiation.

  1998cited by this paper
• Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts*

  1997cited by this paper
• Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

  1997cited by this paper
• PARP is important for genomic stability but dispensable in apoptosis.

  1997cited by this paper
• Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.

  1995cited by this paper
• Damage induced in episomal EBV DNA in Raji cells by antitumor drugs as measured by pulsed field gel electrophoresis.

  1994cited by this paper
• Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 125I decay.

  1991cited by this paper
• Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA.

  1991cited by this paper
• Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells

  1991cited by this paper
• Use of a ring chromosome and pulsed-field gels to study interhomolog recombination, double-strand DNA breaks and sister-chromatid exchange in yeast.

  1989cited by this paper
• Further studies of the induction and intracellular repair of DNA strand breaks using intranuclear SV40 as a test system.

  1988cited by this paper
• A simple technique for quantitation of low levels of DNA damage in individual cells.

  1988cited by this paper
• Chromatin structure of Epstein-Barr virus.

  1985cited by this paper
• Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines

  1979cited by this paper
• Radiation: Studies of Mouse Cells Lacking P53-mediated Dna Repair Responses to Uv

  year unknowncited by this paper

• Global Proteomic Determination of the Poly-Pharmacological Effects of PARP Inhibitors Following Treatment of High-Grade Serous Ovarian Cancer Cells

  2025cites this paper
• Cell Senescence and the DNA Single-Strand Break Damage Repair Pathway

  2024cites this paper
• Epstein-Barr virus deubiquitinating enzyme BPLF1 is involved in EBV carcinogenesis by affecting cellular genomic stability

  2024cites this paper
• Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review)

  2023cites this paper
• Why medicines work.

  2022cites this paper
• Recent advances in phenotypic drug discovery [version 1; peer review: 2 approved]

  2022cites this paper
• PARP inhibitors in small cell lung cancer: The underlying mechanisms and clinical implications.

  2022cites this paper
• DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids

  2021cites this paper
• Poly (ADP-ribose) polymerase inhibitors sensitize cancer cells to hypofractionated radiotherapy through altered selection of DNA double-strand break repair pathways

  2021cites this paper
• Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress

  2021cites this paper
• A Brief Overview and Update on Major Molecular Genomic Alterations in Solid, Bone and Soft Tissue Tumors, Hematopoietic As Well As Lymphoid Malignancies.

  2021cites this paper
• Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action, Pharmacology, Safety, and Efficacy

  2021cites this paper
• Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks

  2021cites this paper
• Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.

  2021cites this paper
• Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

  2020cites this paper
• Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes

  2020cites this paper
• An assessment of poly (ADP‐ribose) polymerase‐1 role in normal and cancer cells

  2020cites this paper
• Recent advances in phenotypic drug discovery

  2020cites this paper
• The kinase polypharmacology landscape of clinical PARP inhibitors

  2020cites this paper
• The off-target kinase landscape of clinical PARP inhibitors

  2019cites this paper
• ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2−/− Ovarian Cancer Cells

  2019cites this paper
• Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress–induced association of Cockayne syndrome group B protein with chromatin

  2018cites this paper
• Mechanisms Underlying Oxidative Stress-Induced Chromatin Association Of Cockayne Syndrome Protein B (csb)

  2018cites this paper
• Impact phénotypique des réarrangements chromosomiques et évolution des génomes de levures

  2018influential citation
• Nick-initiated homologous recombination: Protecting the genome, one strand at a time.

  2017cites this paper
• Investigation into the relationship between PARPs in DNA repair and synthetic lethality with homologous recombination deficiency

  2017cites this paper
• Co-targeting c-Met and DNA double-strand breaks (DSBs): Therapeutic strategies in BRCA-mutated gastric carcinomas.

  2017cites this paper
• Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection

  2015cites this paper
• The role of Rak in the regulation of stability and function of BRCA1

  2015cites this paper
• DNA Damage of Glioblastoma Multiform Cells Induced by Beta Radiation of Iodine-131 in The Presence or Absence of Topotecan: A Picogreen and Colonogenic Assay

  2015cites this paper
• The Role of PARPs in DNA Strand Break Repair

  2015cites this paper
• Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population.

  2015cites this paper
• A Phase 2, Single Arm Study of Iniparib in Patients With BRCA1 or BRCA2 Associated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

  2015cites this paper
• Protein ADP-ribosylation and the cellular response to DNA strand breaks.

  2014cites this paper
• Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors

  2014cites this paper
• Doubling Down on the PI 3 K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness 1 , 2

  2014cites this paper
• DNA single-strand break repair.

  2014cites this paper
• Minor grove binding ligands disrupt PARP-1 activation pathways

  2014cites this paper
• Sources of DNA double-strand breaks and models of recombinational DNA repair.

  2014cites this paper
• Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.

  2014cites this paper
• TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition

  2014cites this paper
• Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp 1 Citation

  2013cites this paper
• Identification de nouveaux partenaires protéiques de l'oncoprotéine Ets-1 et étude de sa régulation par l'enzyme de réparation de l'ADN PARP-1 au sein des cellules tumorales

  2013cites this paper
• Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

  2013cites this paper
• Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease

  2013cites this paper
• An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells

  2013cites this paper
• Repair of DNA Strand Breaks in a Minichromosome In Vivo: Kinetics, Modeling, and Effects of Inhibitors

  2013cites this paper
• Formation and repair of DNA double-strand breaks caused by ionizing radiation in the Epstein-Barr virus minichromosome

  2012cites this paper