Modeling the Non–Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Anesthesiology

• Publication date

  2010-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/ALN.0b013e3181d69087PMID 20461001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integration of Respiratory Responses to Changes in Alveolar Partial Pressures of CO2 and O2 and in Arterial pH

  2011cited by this paper
• Deaths With Transdermal Fentanyl Patches

  2010cited by this paper
• Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression

  2010cited by this paper
• Rate of Occurrence, Gross Appearance, and Age Relation of Hyperostosis Frontalis Interna in Females: A Prospective Autopsy Study

  2010cited by this paper
• The effect of remifentanil on respiratory variability, evaluated with dynamic modeling.

  2009cited by this paper
• Opioids and the control of respiration.

  2008influential reference
• Plasticity of Central Chemoreceptors: Effect of Bilateral Carotid Body Resection on Central CO2 Sensitivity

  2007cited by this paper
• Mechanism‐based PK/PD Modeling of the Respiratory Depressant Effect of Buprenorphine and Fentanyl in Healthy Volunteers

  2007cited by this paper
• Fatal Respiratory Depression after Multiple Intravenous Morphine Injections

  2006cited by this paper
• Modelling the dynamic ventilatory response to hypoxia in humans

  2006cited by this paper
• Mixed-effects Modeling of the Intrinsic Ventilatory Depressant Potency of Propofol in the Non-steady State

  2004cited by this paper
• Remifentanil by bolus injection: a safety, pharmacokinetic, pharmacodynamic, and age effect investigation in human volunteers.

  2004cited by this paper
• A Model of the Ventilatory Depressant Potency of Remifentanil in the Non–steady State

  2003influential reference
• Pharmacodynamic Effect of Morphine-6-glucuronide versus Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers

  2003cited by this paper
• Response Surface Modeling of Remifentanil–Propofol Interaction on Cardiorespiratory Control and Bispectral Index

  2003influential reference
• Influence of anaesthesia and analgesia on the control of breathing.

  2003influential reference
• Nunn's Applied Respiratory Physiology, 5th Edition.

  2002cited by this paper
• Response Surface Modeling of Alfentanil-Sevoflurane Interaction on Cardiorespiratory Control and Bispectral Index

  2001cited by this paper
• Mechanisms of Direct Inhibitory Action of Propofol on Uterine Smooth Muscle Contraction in Pregnant Rats

  2001cited by this paper
• Sex Differences in Morphine Analgesia: An Experimental Study in Healthy Volunteers

  2000cited by this paper
• The Pharmacodynamic Effect of a Remifentanil Bolus on Ventilatory Control

  2000influential reference
• Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil.

  1999influential reference
• Sex‐related Differences in the Influence of Morphine on Ventilatory Control in Humans

  1998cited by this paper
• The pharmacodynamic effect of a remifentanil bolus on ventilatory control.

  1998cited by this paper
• Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development

  1997influential reference
• Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development

  1997cited by this paper
• Pharmacokinetics and Pharmacodynamics of Remifentanil in Volunteer Subjects with Severe Liver Disease

  1996cited by this paper
• Time course of ventilatory depression following induction doses of propofol and thiopental.

  1991cited by this paper
• The influence of oxygen on the ventilatory response to carbon dioxide in man.

  1990influential reference
• The steady‐state and rebreathing methods compared during morphine administration in humans.

  1989cited by this paper
• Assessment of the effects of drugs on respiration.

  1982cited by this paper
• The Effect of Sleep Plus Morphine on the Respiratory Response to Carbon Dioxide

  1964cited by this paper

• The Effect of Deep Sedation with High Flow Nasal Oxygen Therapy on the Transcutaneous CO2 and Mitochondrial Oxygenation: A Single-Center Observational Study

  2025cites this paper
• Fentanyl-induced ventilatory depression: population pharmacokinetic/ pharmacodynamic framework for evaluation of opioid-induced ventilatory depression.

  2025cites this paper
• Tailoring non-invasive respiratory supports in acute hypoxemic respiratory failure: A practical approach for clinicians.

  2025cites this paper
• Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest

  2024cites this paper
• Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001: A Randomized Controlled Trial

  2024cites this paper
• Continuous positive airway pressure is unsafe for radiofrequency ablation of lung cancer under sedation: a randomised controlled trial

  2024cites this paper
• Oral Oxycodone‐Induced Respiratory Depression During Normocapnia and Hypercapnia: A Pharmacokinetic‐Pharmacodynamic Modeling Study

  2023cites this paper
• The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System

  2023cites this paper
• Efficacy and safety of esketamine for sedation among patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis

  2023cites this paper
• A biomarker of opioid-induced respiratory toxicity in experimental studies

  2023cites this paper
• Nocturnal respiratory abnormalities among ward-level postoperative patients as detected by the Capnostream 20p monitor: A blinded observational study

  2023cites this paper
• Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation.

  2022cites this paper
• The pathophysiology of opioid-induced respiratory depression.

  2022cites this paper
• Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest

  2022cites this paper
• Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study

  2022cites this paper
• Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study

  2022cites this paper
• Carbon dioxide tolerability and toxicity in rat and man: A translational study

  2022cites this paper
• Detection of opioid effect with pupillometry.

  2021cites this paper
• A systematic review and meta-analysis of the safety and efficacy of remifentanil and dexmedetomidine for awake fiberoptic endoscope intubation

  2021cites this paper
• Does the preparation for intravenous administration affect the composition of heroin injections? A controlled laboratory study.

  2021cites this paper
• Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial

  2021cites this paper
• Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression

  2021cites this paper
• Analgesic comparison of dezocine plus propofol versus fentanyl plus propofol for gastrointestinal endoscopy

  2021cites this paper
• Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids

  2021cites this paper
• Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial

  2020cites this paper
• Effects of Bispectral Index-controlled Use of Magnesium on Propofol Consumption and Sedation Level in Patients Undergoing Colonoscopy

  2019cites this paper
• Non–steady State Modeling of the Ventilatory Depressant Effect of Remifentanil in Awake Patients Experiencing Moderate-to-severe Obstructive Sleep Apnea

  2019cites this paper
• Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial

  2019cites this paper
• GIVE UP ON REMIFENTANIL LABOR ANALGESIA: India-Based Anesthesiologist And America-Based Anesthesiologist Siblings' Dialogue Series

  2019cites this paper
• Esketamine counters opioid‐induced respiratory depression

  2018cites this paper
• Postoperative Pain Management in Adult Cardiac Surgery

  2018cites this paper
• Pharmacokinetic and pharmacodynamic analysis in anesthesia : a modeling odyssey

  2017cites this paper
• The Comparison of Etomidate and Propofol Anesthesia in Patients Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis

  2017cites this paper
• Drug Interactions in Anesthesia

  2017cites this paper
• exchange during Mechanical Ventilation

  2016cites this paper
• Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2

  2016influential citation
• A Comparative Data-Based Modeling Study on Respiratory CO2 Gas Exchange during Mechanical Ventilation

  2016cites this paper
• Dexmedetomidine vs propofol-remifentanil conscious sedation for awake craniotomy: a prospective randomized controlled trial.

  2016cites this paper
• Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study.

  2016influential citation
• Pregabalin Has Analgesic, Ventilatory, and Cognitive Effects in Combination with Remifentanil

  2016cites this paper
• Pharmacokinetic–pharmacodynamic modelling in anaesthesia

  2015cites this paper
• Opioid-induced respiratory depression in the acute care setting: a compendium of case reports.

  2014cites this paper
• USO DO REMIFENTANIL PARA REDUÇÃO DA DOSE DE PROPOFOL E DA DOR À SUA INJEÇÃO EM EXAMES DE ENDOSCOPIA DIGESTIVA ALTA DIAGNÓSTICOS

  2014cites this paper
• Postoperative Pain Management in Cardiac Surgery

  2014cites this paper
• Pharmacokinetic and pharmacodynamic modeling for acute and chronic pain drug assessment

  2014cites this paper
• Sedation in non-invasive ventilation: do we know what to do (and why)?

  2014cites this paper
• Opioid-induced respiratory depression: reversal by non-opioid drugs

  2014cites this paper
• Remifentanil as analgesia for labour pain

  2013cites this paper
• Comparison between monitored anesthesia care with remifentanil under ilioinguinal hypogastric nerve block and spinal anesthesia for herniorrhaphy

  2013cites this paper
• Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

  2013cites this paper
• Efficacy of endotracheal lidocaine administration with continuous infusion of remifentanil for attenuating tube-induced coughing during emergence from total intravenous anesthesia

  2013cites this paper
• Problems in obtaining sufficient anaesthesia with propofol and remifentanil: three cases, a test infusion, and a review.

  2013cites this paper
• Opioid therapy : a trade-off between opioid-analgesia and opioid-induced respiratory depression

  2013cites this paper
• The Large Role of Prescription Drugs in Accidental Drug Deaths

  2013cites this paper
• Opioid therapy : a trade-off between opioid-analgesia and opioid-induced respiratory depression

  2013cites this paper
• Conscious sedation for awake fibreoptic intubation: a review of the literature

  2013cites this paper
• Efficacy and side effects of intravenous remifentanil patient-controlled analgesia used in a stepwise approach for labour: an observational study.

  2013cites this paper
• Flexible fiberoptic bronchoscopy and remifentanil target-controlled infusion in ICU: a preliminary study

  2012cites this paper
• Multiples of Minimal Alveolar Concentration of Volatile Agents Are Not Necessarily Equipotent

  2011influential citation
• Opioid Modeling of Central Respiratory Drive Must Take Upper Airway Obstruction into Account

  2011cites this paper
• Opioid modeling of central respiratory drive must take upper airway obstruction into account.

  2011cites this paper
• Pharmacodynamic modeling of propofol-induced tidal volume depression in children

  2011cites this paper
• Laser Ablation of a Large Tongue Hemangioma with Remifentanil Analgosedation in the ORL Endoscopy Suite

  2011cites this paper
• Anesthetics and control of breathing.

  2011cites this paper
• Timing of intravenous patient‐controlled remifentanil bolus during early labour

  2011cites this paper
• Postoperative Opioids Remain a Serious Patient Safety Threat

  2010cites this paper
• Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling Study

  2010cites this paper
• Safety and efficacy of etomidate and propofol anesthesia in Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind elderly patients undergoing gastroscopy: A double-blind randomized clinical study randomized clinical study

  year unknowncites this paper