An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis.

Mounting evidence supports a 'lipostatic' model for the regulation of adipose mass. In such a model, signals are generated in the periphery in proportion to adipose mass that act on hypothalamic control centers in the brain to regulate food intake and energy expenditure. Two such signals, leptin and insulin, have been identified and found to dramatically lower food intake and body weight. Several signalling molecules in the effector pathways that mediate the response to these signals in the brain have also been identified. The regulation of these factors and the nature of the adipose-CNS regulatory loop will be discussed.

• Publication year

  1999

• Venue

  Seminars in Cell and Developmental Biology

• Publication date

  1999-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/SCDB.1998.0274PMID 10355024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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