Assessment of vitamin K status of the newborn infant.

This article reviews our current knowledge of the assessment of vitamin K status in the human infant, where a deficiency state has been described. Laboratory measures for the functional assessment of vitamin K-dependent coagulation factors as well as the quantitative assay for vitamin K1 (phylloquinone) are reviewed. In addition, four different methods of measuring abnormal prothrombin, a protein induced by vitamin K absence (PIVKA-II), and its use in clinical pediatrics are discussed. Finally, additional methods are briefly described for assessing vitamin K status, including serum osteocalcin, urinary excretion of gamma-carboxyglutamic acid, and deficiencies of the enzymes necessary for the regeneration of phylloquinone in the so-called vitamin K cycle.

• Publication year

  1993

• Venue

  Journal of Pediatric Gastroenterology and Nutrition - JPGN

• Publication date

  1993-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00005176-199304000-00001PMID 8492247
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitamin K status of lactating mothers, human milk, and breast-feeding infants.

  1991cited by this paper
• Comparison of oral and parenteral vitamin K prophylaxis for prevention of late hemorrhagic disease of the newborn.

  1991cited by this paper
• Haemorrhagic disease of the newborn in the British Isles: two year prospective study.

  1991cited by this paper
• Vitamin K1 levels and K1-dependent coagulation factors II and X in preterm and small-for-date neonates

  1990cited by this paper
• Vitamin K1 levels and coagulation factors in healthy term newborns till 4 weeks after birth.

  1990cited by this paper
• Oral Supplementation of Vitamin K for Pregnant Women and Effects on Levels of Plasma Vitamin K and PIVKA‐II in the Neonate

  1990cited by this paper
• Relationship of milk intake and vitamin K supplementation to vitamin K status in newborns.

  1989cited by this paper
• Vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) status in newborns during the first week of life.

  1988cited by this paper
• A rapid and simple micromethod for the specific determination of descarboxylated prothrombin (PIVKA II).

  1988cited by this paper
• Circulating Osteocalcin During Oral Anticoagulant Therapy

  1988cited by this paper
• Location of gamma-carboxyglutamyl residues in partially carboxylated prothrombin preparations.

  1988cited by this paper
• Placental Transfer of Vitamin K1 and Its Implications in Fetal Hemostasis

  1988cited by this paper
• Role of vitamin-K-dependent proteins in bone metabolism.

  1988cited by this paper
• Plasma concentrations of vitamin K1 and PIVKA-II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth

  1988cited by this paper
• Vitamin K in the newborn: influence of nutritional factors on acarboxy-prothrombin detectability and factor II and VII clotting activity

  1987cited by this paper
• Screening for late neonatal vitamin K deficiency by acarboxyprothrombin in dried blood spots.

  1987cited by this paper
• Development of the human coagulation system in the full-term infant.

  1987cited by this paper
• The placental transport of [3H] vitamin K1 in rats

  1987cited by this paper
• Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K.

  1987cited by this paper
• Vitamin K counteracts the effect of warfarin in liver but not in bone.

  1987cited by this paper
• Serum osteocalcin concentrations in infancy: lower values in those fed cow milk formula versus breast feeding.

  1987cited by this paper
• Perinatal serum bone Gla-protein and vitamin D metabolites in preterm and fullterm neonates.

  1987cited by this paper
• Vitamin K deficiency in the newborn infant: prevalence and perinatal risk factors.

  1986cited by this paper
• Vitamin-K status beyond the neonatal period

  1986cited by this paper
• Vitamin K Deficiency in Breast‐Fed Infants at One Month of Age

  1986cited by this paper
• Liquid-chromatographic determination of vitamin K1 in plasma, with fluorometric detection.

  1986cited by this paper
• Serum vitamin K1 concentrations after oral administration of vitamin K1 in low birth weight infants.

  1985cited by this paper
• Latent vitamin K deficiency in healthy infants.

  1985cited by this paper
• Plasma concentrations after oral or intramuscular vitamin K1 in neonates.

  1985cited by this paper
• Vitamin K deficiency in the newborn.

  1985cited by this paper
• Mother‐Infant Prothrombin Precursor Status at Birth

  1984cited by this paper
• Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma.

  1984cited by this paper
• Studies on precursor proteins PIVKA-II, -IX, and -X in the plasma of patients with 'hemorrhagic disease of the newborn'.

  1984cited by this paper
• Acarboxy prothrombin in cord plasma from normal neonates.

  1984cited by this paper
• Plasma vitamin K1 in mothers and their newborn babies.

  1982cited by this paper
• Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.

  1981cited by this paper
• Factor II (prothrombin) levels in cord blood: correlation of coagulant activity with immunoreactive protein.

  1980cited by this paper
• Evidence against Vitamin K Deficiency in Normal Neonates

  1980cited by this paper
• Immunologic Studies of Prothrombin in Newborns

  1979cited by this paper
• Heparin-like inhibitor, not vitamin-K deficiency, in the newborn.

  1977cited by this paper
• Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction.

  1968cited by this paper
• Nature of Prothrombin Biosynthesis : Preprothrombinæmia in Vitamin K-deficiency

  1963cited by this paper

• Select micronutrients for the preterm neonate.

  2023cites this paper
• Vitamin K Deficiency Bleeding in Infancy

  2020cites this paper
• Vitamins, 5. Vitamin K

  2020cites this paper
• Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

  2017cites this paper
• Vitamin K profylakse til nyfødte

  2015cites this paper
• Impact of Supplemental Vitamin K1 Administration on Postoperative Blood Component Requirements After Craniosynostosis Repair: A Prospective, Placebo-Controlled, Randomized, Blinded Study

  2014influential citation
• Chapter 10 – Controversies in Neonatal Nutrition: Macronutrients and Micronutrients

  2012cites this paper
• PIVKA-II plasma levels as markers of subclinical vitamin K deficiency in term infants

  2012influential citation
• Vitamin K the basics--what's new?

  2010cites this paper
• Chapter 13 – Macro and Micronutrients

  2008cites this paper
• Neonatal Nutrition and Metabolism: Vitamins

  2006cites this paper
• Prevalence of Vitamin K Deficiency in Children with Mild to Moderate Chronic Liver Disease

  2006cites this paper
• Vitamin K deficiency mimicking child abuse.

  2005cites this paper
• Des-gamma-carboxyprothrombin (PIVKA-II) levels in maternal serum throughout gestation.

  2005cites this paper
• Des-Gamma-Carboxyprothrombin (PIVKA-II) Levels in Maternal Serum throughout Gestation

  2005cites this paper
• Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40).

  2002cites this paper
• Studies on the role of vitamin K1 and K2 in bone metabolism and cardiovascular disease : structural differences determine different metabolic pathways

  2002cites this paper
• Vitamin K and tissue mineralization.

  2001cites this paper
• Variation of Des-Gamma-Carboxyprothrombin (PIVKA-II) Levels in Cord Blood Throughout Gestation

  2001cites this paper
• Vitamin K status of premature infants: implications for current recommendations.

  2001cites this paper
• Variation of des-gamma-carboxyprothrombin (PIVKA-II) levels in cord blood throughout gestation.

  2001cites this paper
• Are breast-fed infants vitamin K deficient?

  2001cites this paper
• Vitamin metabolism and requirements in the micropremie.

  2000cites this paper
• Prevalence of vitamin K deficiency in cystic fibrosis.

  1999cites this paper
• Late-form hemorrhagic disease of the newborn: a fatal case report with illustration of investigations that may assist in avoiding the mistaken diagnosis of child abuse.

  1999cites this paper
• Vitamin K status of lactating mothers and their infants

  1999cites this paper
• Late-form hemorrhagic disease of the newborn: a fatal case report with illustration of investigations that may assist in avoiding the mistaken diagnosis of child abuse

  1999cites this paper
• A new mixed micellar preparation for oral vitamin K prophylaxis: randomised controlled comparison with an intramuscular formulation in breast fed infants

  1998cites this paper
• A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis.

  1997cites this paper
• Chapter 49 Vitamin K: Metabolic functions, mechanism of action, and human requirements

  1997cites this paper
• Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements.

  1997cites this paper
• The riddle of vitamin K1 deficit in the newborn.

  1997cites this paper
• Effects of vitamin K on bone mass and bone metabolism.

  1996cites this paper
• Effects of oral and intramuscular vitamin K prophylaxis on PIVKA-II assay parameters in breastfed infants in Turkey.

  1996cites this paper
• Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population.

  1996cites this paper
• Vitamin K deficiency and hemorrhage in infancy.

  1995cites this paper
• Vitamin K and energy transduction: a base strength amplification mechanism.

  1995cites this paper
• Vitamin K Deficiency Bleeding in Infants and Children

  1995cites this paper
• [Syringes for oral administration of vitamin K1 lipid emulsion].

  1995cites this paper
• Human Bioavailability of Vitamins

  1994cites this paper