Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  European journal of medicinal chemistry

• Publication date

  2013-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2013.02.003PMID 23474900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advances in Targeting Voltage‐Gated Sodium Channels with Small Molecules

  2012cited by this paper
• Recent Advances in the Pharmacological Management of Pain

  2012cited by this paper
• Drugs of anaesthesia and cancer.

  2010cited by this paper
• Update on local anesthetics

  2010cited by this paper
• Safety of amide local anesthetics: new trends

  2010cited by this paper
• The acute toxicity of local anesthetics

  2010cited by this paper
• Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models.

  2010cited by this paper
• 2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.

  2009cited by this paper
• Clinical Presentation of Local Anesthetic Systemic Toxicity: A Review of Published Cases, 1979 to 2009

  2009cited by this paper
• Survey of local anesthetic use by Ontario dentists.

  2009cited by this paper
• Adverse Drug Reactions to Local Anaesthetics

  2009cited by this paper
• This Month in ANESTHESIOLOGY

  2005cited by this paper
• Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study.

  2005cited by this paper
• Synthesis and antibacterial properties of ampholyte preparations from dodecylamine

  2004cited by this paper
• AZ acycloalkanes

  2004cited by this paper
• Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)

  2003cited by this paper
• Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.

  2003cited by this paper
• Xylocain (Lidocaine, Lignocaine), its discovery and Gordh's contribution to its clinical use

  1998cited by this paper
• Comparative Inhibition of Voltage‐Gated Cation Channels by Local Anesthetics a

  1991cited by this paper
• Investigation of the mechanisms of the anesthetizing activity of pyromecaine, cyclomecaine, and their benzyl analog

  1986cited by this paper
• [Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].

  1983cited by this paper
• Cardiac arrest following regional anesthesia with etidocaine or bupivacaine.

  1979cited by this paper
• [A rapid method for the determination of the median effective dose and its errors].

  1978cited by this paper
• Azacycloalkanes VIII. Aromatic amides of N-substitutedα-pyrrolidinedicarboxylic acids

  1970cited by this paper
• Drugs

  1967cited by this paper
• Local Anesthetics I. N-Alkyl Pyrrolidine and N-Alkyl Piperidine Carboxylic Acid Amides.

  1957cited by this paper
• Trials with carbocaine; a new local anaesthetic drug.

  1956cited by this paper
• VENTRICULAR FIBRILLATION PRECIPITATED BY CARDIAC CATHETERIZATION: Complete Recovery of the Patient After Forty-Five Minutes

  1950cited by this paper
• Ventricular fibrillation precipitated by cardiac catheterization; complete recovery of the patient after 45 minutes.

  1950cited by this paper
• Biological comparison of local anaesthetics.

  1945cited by this paper

• Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation

  2025cites this paper
• Rational Design, Synthesis, and In-Silico Evaluation of Homologous Local Anesthetic Compounds as TASK-1 Channel Blockers

  2020cites this paper
• Synthesis and Quantification of 2-(Diethylamino)-N-(2-methylphenyl)acetamide Nitrate

  2019cites this paper
• The development of local anesthetics and their applications beyond anesthesia

  2019cites this paper
• Synthesis and biological activities of local anesthetics

  2019cites this paper
• Recent Trends in the Discovery of Small Molecule Blockers of Sodium Channels.

  2016cites this paper