Autoinflammatory disorders, pain, and neural regulation of inflammation.

Autoinflammatory disorders are disorders of the innate immune system that are distinct from autoimmune disorders. Dysregulation of the innate immune system, specifically an increase in interleukin-1 beta (IL-1β), gives rise to a spectrum of symptoms marked by inflammation and pain. Identification of causative gene mutations led to the discovery of the inflammasome. Many autoinflammatory disorders also have a strong pain component. The contribution of IL-1β to pain and neural involvement is underappreciated. This article provides an overview of the current autoinflammatory disorders and highlights the contribution IL-1β makes to pain in these disorders.

• Publication year

  2013

• Venue

  Dermatologia clinica

• Publication date

  2013-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.det.2013.04.002PMID 23827248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Relationship between serum interleukin–1β levels and acute phase response proteins in patients with familial Mediterranean fever

  2012cited by this paper
• Increased Urine and Serum Nerve Growth Factor Levels in Interstitial Cystitis Suggest Chronic Inflammation Is Involved in the Pathogenesis of Disease

  2012cited by this paper
• Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis

  2012cited by this paper
• Interleukin-1, inflammasomes, autoinflammation and the skin.

  2012cited by this paper
• Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes

  2012cited by this paper
• Chemokines and cytokines in neuroinflammation leading to neuropathic pain.

  2012cited by this paper
• Rosacea: The cytokine and chemokine network.

  2011cited by this paper
• Blocking interleukin‐1β in acute and chronic autoinflammatory diseases

  2011cited by this paper
• Neurovascular aspects of skin neurogenic inflammation.

  2011cited by this paper
• A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil.

  2011cited by this paper
• Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum

  2011cited by this paper
• Role of inflammation in bladder function and interstitial cystitis

  2011cited by this paper
• The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

  2011cited by this paper
• The inflammasome: an integrated view

  2011cited by this paper
• The role of the NLRP3 inflammasome in gout

  2011cited by this paper
• Tumour necrosis factor receptor trafficking dysfunction opens the TRAPS door to pro-inflammatory cytokine secretion

  2011cited by this paper
• Neurovascular and neuroimmune aspects in the pathophysiology of rosacea.

  2011cited by this paper
• Enhanced NF-κB activation with an inflammasome activator correlates with activity of autoinflammatory disease associated with NLRP3 mutations outside of exon 3: comment on the article by Jéru et al.

  2010cited by this paper
• Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

  2010cited by this paper
• Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study.

  2010cited by this paper
• Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

  2010cited by this paper
• Inflammasomes and Anti-Viral Immunity

  2010cited by this paper
• NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease

  2010cited by this paper
• The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.

  2010cited by this paper
• Autoinflammatory disease reloaded: a clinical perspective.

  2010cited by this paper
• Management strategies for painful bladder syndrome.

  2010cited by this paper
• Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review

  2010cited by this paper
• Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.

  2010cited by this paper
• The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency

  2010cited by this paper
• Fungal pathogen recognition by the NLRP3 inflammasome

  2010cited by this paper
• Inflammasomes as microbial sensors

  2010cited by this paper
• Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

  2009cited by this paper
• Mechano- and thermosensitivity of regenerating cutaneous afferent nerve fibers

  2009cited by this paper
• Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1

  2009cited by this paper
• An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.

  2009cited by this paper
• Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

  2009cited by this paper
• The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

  2009cited by this paper
• Interstitial cystitis: an unsolved enigma.

  2009cited by this paper
• Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

  2009cited by this paper
• The molecular pathology of rosacea.

  2009cited by this paper
• Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

  2009cited by this paper
• Cellular and molecular mechanisms of pain.

  2009cited by this paper
• Missense Mutations in the MEFV Gene Are Associated with Fibromyalgia Syndrome and Correlate with Elevated IL-1β Plasma Levels

  2009cited by this paper
• An autoinflammatory disease due to homozygous deletion of the IL1RN locus.

  2009cited by this paper
• Use of canakinumab in the cryopyrin-associated periodic syndrome.

  2009cited by this paper
• Role of interleukin-1beta during pain and inflammation.

  2009cited by this paper
• A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.

  2009cited by this paper
• The inherited autoinflammatory syndrome: a decade of discovery.

  2009cited by this paper
• Nociceptors Are Interleukin-1β Sensors

  2008cited by this paper
• Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome.

  2008cited by this paper
• Sunburned skin activates inflammasomes.

  2008cited by this paper
• Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

  2008cited by this paper
• Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

  2008cited by this paper
• Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

  2007cited by this paper
• Interstitial cystitis and systemic autoimmune diseases.

  2007cited by this paper
• A pilot study of IL-1 inhibition by anakinra in acute gout

  2007cited by this paper
• Signaling pathways in sensitization: toward a nociceptor cell biology.

  2007cited by this paper
• Management of treatment resistant inflammation of acute on chronic tophaceous gout with anakinra

  2007cited by this paper
• The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.

  2007cited by this paper
• The Neuroimmune Basis of Anti-inflammatory Acupuncture

  2007cited by this paper
• Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

  2007cited by this paper
• Interstitial cystitis and systemic autoimmune diseases

  2007cited by this paper
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1

  2006cited by this paper
• Gout-associated uric acid crystals activate the NALP3 inflammasome

  2006cited by this paper
• Neutrophils: are they hyperalgesic or anti‐hyperalgesic?

  2006cited by this paper
• The systemic autoinflammatory diseases: inborn errors of the innate immune system.

  2006cited by this paper
• A new CARD15 mutation in Blau syndrome

  2005cited by this paper
• Mechanisms of inflammation in gout.

  2005cited by this paper
• Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  2004cited by this paper
• NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

  2004cited by this paper
• Diabetic somatic neuropathies.

  2004cited by this paper
• Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway

  2003cited by this paper
• Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats

  2003cited by this paper
• Interstitial cystitis: understanding the syndrome.

  2003cited by this paper
• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  2003cited by this paper
• Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*

  2003cited by this paper
• Can we conquer pain?

  2002cited by this paper
• Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes.

  2002cited by this paper
• A comparison of multiple urine markers for interstitial cystitis.

  2002cited by this paper
• Neuromodulation for the treatment of refractory interstitial cystitis.

  2002cited by this paper
• Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.

  2002cited by this paper
• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  2002cited by this paper
• Molecular Analysis of the Mevalonate Kinase Gene in a Cohort of Patients with the Hyper-IgD and Periodic Fever Syndrome: Its Application as a Diagnostic Tool

  2001cited by this paper
• Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

  2001cited by this paper
• A recently recognised chronic inflammatory disease of early onset characterised by the triad of rash, central nervous system involvement and arthropathy.

  2001cited by this paper
• Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

  2001cited by this paper
• CARD15 mutations in Blau syndrome

  2001cited by this paper
• Comparative quantification of IL-1beta, IL-10, IL-10r, TNFalpha and IL-7 mRNA levels in UV-irradiated human skin in vivo.

  2000cited by this paper
• Comparative quantification of IL-1β, IL-10, IL-10r, TNFα and IL-7 mRNA levels in UV-irradiated human skin in vivo

  2000cited by this paper
• Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

  1999cited by this paper
• Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.

  1997cited by this paper
• Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16.

  1996cited by this paper
• Autosomal dominant granulomatous arthritis, uveitis, skin rash, and synovial cysts.

  1990cited by this paper
• Familial Mediterranean fever. A survey of 470 cases and review of the literature.

  1967cited by this paper

• Chronic secondary orofacial pain as the first symptom of chronic non-bacterial osteomyelitis in the mandible: a case report and literature review

  2024cites this paper
• Patient Experiences and Challenges in the Management of Autoinflammatory Diseases—Data from the International FMF & AID Global Association Survey

  2024cites this paper
• Predictive Clinical and Biological Criteria for Gene Panel Positivity in Suspected Inherited Autoinflammatory Diseases: Insights from a Case–Control Study

  2023cites this paper
• Elevated interleukin-37 associated with tophus and pro-inflammatory mediators in Chinese gout patients.

  2021cites this paper
• Insulin Promotes Wound Healing by Inactivating NFkβP50/P65 and Activating Protein and Lipid Biosynthesis and alternating Pro/Anti-inflammatory Cytokines Dynamics

  2019cites this paper
• Neural therapy of an athlete’s chronic plantar fasciitis: a case report and review of the literature

  2018cites this paper
• Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development*

  2015cites this paper
• Aportes a la patogenia del dolor: un enfoque desde la Neuroinmunoendocrinología

  2015cites this paper