Regulation of the epithelial sodium channel by accessory proteins.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemical Journal

• Publication date

  2003-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ20021375PMID 12460120PMCID PMC1223251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of individual Nedd4–2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels

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• Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

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• Impaired renal Na(+) retention in the sgk1-knockout mouse.

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• Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.

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• Serum and Glucocorticoid-regulated Kinase Modulates Nedd4-2-mediated Inhibition of the Epithelial Na+Channel*

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• Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors.

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• A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.

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• A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.

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• Non‐specific activation of the epithelial sodium channel by the CFTR chloride channel

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• Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.

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• Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance.

  2001cited by this paper
• Solution structure of a Nedd4 WW domain–ENaC peptide complex

  2001cited by this paper
• Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

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• Characterization of Interactions between Nedd4 and β and γENaC Using Surface Plasmon Resonance

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• ENaC Degradation in A6 Cells by the Ubiquitin-Proteosome Proteolytic Pathway*

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• Sporadic cases of Liddle's syndrome: clues to essential hypertension?

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• Ubiquitin and proteasomes: Protein regulation by monoubiquitin

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• Association of a Sodium Channel α Subunit Promoter Variant with Blood Pressure

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• Molecular Mechanisms of Human Hypertension

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• In vitro phosphorylation of COOH termini of the epithelial Na(+) channel and its effects on channel activity in Xenopus oocytes.

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• The many faces of Ras: recognition of small GTP-binding proteins.

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• Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF*

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• Mechanisms of the inhibition of epithelial Na(+) channels by CFTR and purinergic stimulation.

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• SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.

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• The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl− concentration

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• Trafficking and cell surface stability of ENaC.

  2001cited by this paper
• Effects of the Serine/Threonine Kinase SGK1 on the Epithelial Na+ Channel (ENaC) and CFTR: Implications for Cystic Fibrosis

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• Two sporadic cases of Liddle's syndrome caused by De novo ENaC mutations.

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• Multiple WW Domains, but Not the C2 Domain, Are Required for Inhibition of the Epithelial Na+ Channel by Human Nedd4*

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• CFTR induces the expression of DRA along with Cl(-)/HCO(3)(-) exchange activity in tracheal epithelial cells.

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• Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

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• The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane.

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• Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line.

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• Dysfunction of epithelial sodium transport: from human to mouse.

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• E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway Cells*

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• Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

  2000cited by this paper
• The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel.

  2000cited by this paper
• Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits.

  2000cited by this paper
• Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function

  1999cited by this paper
• Epithelial sodium channel regulated by aldosterone-induced protein sgk.

  1999cited by this paper
• Early aldosterone action: toward filling the gap between transcription and transport.

  1999cited by this paper
• Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption.

  1999cited by this paper
• Regulation of the Amiloride-sensitive Epithelial Sodium Channel by Syntaxin 1A*

  1999cited by this paper
• Hormonal Regulation and Genomic Organization of the Human Amiloride-Sensitive Epithelial Sodium Channel α Subunit Gene

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• Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.

  1999cited by this paper
• Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

  1999cited by this paper
• Role of CFTR in airway disease.

  1999cited by this paper
• Interaction of Syntaxins with the Amiloride-sensitive Epithelial Sodium Channel*

  1999cited by this paper
• Serum and glucocorticoid‐inducible kinase (SGK) is a target of the PI 3‐kinase‐stimulated signaling pathway

  1999cited by this paper
• Number of Subunits Comprising the Epithelial Sodium Channel*

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• The Serum and Glucocorticoid Kinase sgk Increases the Abundance of Epithelial Sodium Channels in the Plasma Membrane of Xenopus Oocytes*

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• Regulation of Cl−/ HCO3 −Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells*

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• Biosynthesis and Processing of Epithelial Sodium Channels inXenopus Oocytes*

  1998cited by this paper
• Cl− transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co‐expressing CFTR and ENaC

  1998cited by this paper
• Epithelial sodium channel regulatory proteins identified by functional expression cloning.

  1998cited by this paper
• Protease Modulation of the Activity of the Epithelial Sodium Channel Expressed in Xenopus Oocytes

  1998cited by this paper
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• The Activity of the Epithelial Sodium Channel Is Regulated by Clathrin-mediated Endocytosis*

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• Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Ubiquitin-dependent protein degradation.

  1996cited by this paper
• CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells.

  1995cited by this paper
• A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• Aldosterone action.

  1993cited by this paper
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