Blast-Induced Neurotrauma Models and Their Requirements

Although advances are being made in identifying some of the essential mechanisms that may lead to chronic neurological deficits after blast-exposure(s), clinical needs continue to exceed current knowledge. In their current article, Brenner and colleagues address the importance of basic science in guiding new diagnostic and treatment strategies. Together with Wilkinson et al., they emphasize one of the basic tenets of experimental biomedical research: to reliably reproduce pathological conditions including neuroendocrine (1) and behavioral changes (2) seen in blast-exposed

• Publication year

  2014

• Venue

  Frontiers in Neurology

• Publication date

  2014-07-10

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.3389/fneur.2014.00128PMID 25071713PMCID 4091031
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain Response to Primary Blast Wave Using Validated Finite Element Models of Human Head and Advanced Combat Helmet

  2013cited by this paper
• Experimental Animal Models for Studies on the Mechanisms of Blast-Induced Neurotrauma

  2012cited by this paper
• Porcine Head Response to Blast

  2012cited by this paper
• Assessment of the Effects of Acute and Repeated Exposure to Blast Overpressure in Rodents: Toward a Greater Understanding of Blast and the Potential Ramifications for Injury in Humans Exposed to Blast

  2012cited by this paper
• Neuro-Glial and Systemic Mechanisms of Pathological Responses in Rat Models of Primary Blast Overpressure Compared to “Composite” Blast

  2012cited by this paper
• A Multiscale Approach to Blast Neurotrauma Modeling: Part II: Methodology for Inducing Blast Injury to in vitro Models

  2012cited by this paper
• Perspectives on Creating Clinically Relevant Blast Models for Mild Traumatic Brain Injury and Post Traumatic Stress Disorder Symptoms

  2012cited by this paper
• High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast-Related Mild Traumatic Brain Injury

  2011cited by this paper
• Traumatic Brain Injury: An Overview of Pathobiology with Emphasis on Military Populations

  2010cited by this paper
• Therapeutic Hypothermia: Critical Review of the Molecular Mechanisms of Action

  2010cited by this paper
• Animal models of head trauma

  2005cited by this paper

• The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma

  2024cites this paper
• Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging

  2024cites this paper
• Blast-related traumatic brain injury is mediated by the kynurenine pathway

  2022cites this paper
• Experimental model for the study of traumatic brain injury

  2021cites this paper
• Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement

  2021cites this paper
• Development of a new militarily-relevant whole-body low-intensity blast model for mild and subconcussive traumatic brain injury: Examination of acute neurological and multi-organ pathological outcomes

  2021cites this paper
• Retrospective Analysis and Current State of Experimental Models of Blast-induced Trauma

  2020cites this paper
• Improving Understanding and Outcomes of Traumatic Brain Injury Using Bidirectional Translational Research

  2020cites this paper
• A Systematic Review of Large Animal Models of Combined Traumatic Brain Injury and Hemorrhagic Shock.

  2019cites this paper
• Acute neurocognitive deficits in active duty service members following subconcussive blast exposure

  2019cites this paper
• Animal Models of Neurotrauma

  2019influential citation
• Utilization of Shock Tubes in Blast Injury Research

  2019cites this paper
• Large animal models of traumatic brain injury

  2018cites this paper
• Large animal models of stroke and traumatic brain injury as translational tools.

  2018cites this paper
• Adoption of the Transport and Burgers' Equations in Modeling Neurological Shock-Waves in the Human Brain Due to Improvised Explosive Devices (IEDs)

  2018cites this paper
• Blast Scaling Parameters: Transitioning from Lung to Skull Base Metrics.

  2017cites this paper
• Understanding blast-induced neurotrauma: how far have we come?

  2017cites this paper
• An Investigation Of The Mechanism Of Traumatic Brain Injury Caused By Blast In The Open Field

  2017cites this paper
• Modelling Blast Brain Injury

  2016cites this paper
• Biomechanical Responses of the Brain in Swine Subject to Free-Field Blasts

  2016influential citation
• Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction

  2016cites this paper
• Vascular and Inflammatory Factors in the Pathophysiology of Blast-Induced Brain Injury

  2015cites this paper
• The Temporal Pattern of Changes in Serum Biomarker Levels Reveals Complex and Dynamically Changing Pathologies after Exposure to a Single Low-Intensity Blast in Mice

  2015cites this paper
• Effects of Low-Level Blast Exposure on the Nervous System: Is There Really a Controversy?

  2014cites this paper