Computational modeling of drug distribution in the posterior segment of the eye: effects of device variables and positions.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Mathematical Biosciences

• Publication date

  2014-09-01

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.mbs.2014.06.008PMID 24946303
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitreous substitutes: a comprehensive review.

  2011cited by this paper
• Sustained Release Intraocular Drug Delivery Devices for Treatment of Uveitis

  2011cited by this paper
• Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography.

  2010cited by this paper
• Novel Drug Delivery Systems for Retinal Diseases

  2009cited by this paper
• Dimensions of the human sclera: Thickness measurement and regional changes with axial length.

  2009cited by this paper
• Sustained transscleral drug delivery

  2008cited by this paper
• Computer Modeling of Drug Delivery to the Posterior Eye: Effect of Active Transport and Loss to Choroidal Blood Flow

  2008cited by this paper
• Computational modeling of intravitreal drug delivery in the vitreous chamber with different vitreous substitutes

  2008cited by this paper
• A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis.

  2006cited by this paper
• In vitro dimensions and curvatures of human lenses.

  2006cited by this paper
• Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling.

  2006cited by this paper
• Evaluation of coupled convective-diffusive transport of drugs administered by intravitreal injection and controlled release implant.

  2005cited by this paper
• Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging

  2005cited by this paper
• Drug delivery systems for vitreoretinal diseases.

  2004cited by this paper
• Permeability and Diffusion in Vitreous Humor: Implications for Drug Delivery

  2004cited by this paper
• Computer Simulation of Convective and Diffusive Transport of Controlled-Release Drugs in the Vitreous Humor

  2004cited by this paper
• Drug delivery to the retina: challenges and opportunities

  2003cited by this paper
• Hydraulic Flow and Vascular Clearance Influences on Intravitreal Drug Delivery

  2002cited by this paper
• Diurnal Variation of Episcleral Venous Pressure in Healthy Patients: A Pilot Study

  2001cited by this paper
• Transscleral drug delivery for posterior segment disease.

  2001cited by this paper
• Ophthalmology: A Pocket Textbook Atlas

  2000cited by this paper
• Relationship between anterior chamber depth, refractive state, corneal diameter, and axial length.

  2000cited by this paper
• Drug delivery for posterior segment eye disease.

  2000cited by this paper
• Ophthalmic drug delivery systems--recent advances.

  1998cited by this paper
• Drug distribution in the vitreous humor of the human eye: the effects of intravitreal injection position and volume.

  1997cited by this paper
• Finite element modeling of drug distribution in the vitreous humor of the rabbit eye

  1997cited by this paper
• Drug Distribution in the Vitreous Humor of the Human Eye: The Effects of Aphakia and Changes in Retinal Permeability and Vitreous Diffusivity

  1997cited by this paper
• Pharmacokinetic model of intravitreal drug injection.

  1994cited by this paper
• In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation.

  1994cited by this paper
• The loss of fluorescein, fluorescein glucuronide and fluorescein isothiocyanate dextran from the vitreous by the anterior and retinal pathways.

  1991cited by this paper
• Clinical Anatomy of the Eye

  1990cited by this paper
• Measurement of the volume flow and hydraulic conductivity across the isolated dog retinal pigment epithelium.

  1987cited by this paper
• Estimation of the permeability of the blood-retinal barrier in normal individuals.

  1985cited by this paper
• Pharmacokinetic interpretation of vitreous fluorophotometry.

  1983cited by this paper
• Outward transport of fluorescein from the vitreous in normal human subjects.

  1983cited by this paper
• Pharmacokinetics of fluorescein in the vitreous.

  1981cited by this paper
• Management of infectious endophthalmitis.

  1980cited by this paper
• Toxicity of selected antibiotics in vitreous replacement fluid.

  1977cited by this paper
• Flow of water in the sclera.

  1970cited by this paper

• Effect of Molecular Size on Ocular Drug Distribution After Intravitreal Injection Using Computed Tomography and Mathematical Spatial Modeling

  2025cites this paper
• Human nerve growth factor delivery to the retina: Quantitative methodology and mathematical modeling in preclinical settings

  2025cites this paper
• Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies

  2024cites this paper
• Advancing glaucoma research with multiphysics continuum mechanics modelling: Opportunities and open challenges.

  2024cites this paper
• Effective prediction of drug transport in a partially liquefied vitreous humor: Physics-informed neural network modeling for irregular liquefaction geometry

  2024cites this paper
• Drug Delivery from a Ring Implant Attached to Intraocular Lens: An in-silico Investigation.

  2024cites this paper
• Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity.

  2024cites this paper
• A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

  2024cites this paper
• Effect of twisting of intravitreal injections on ocular bio-mechanics: a novel insight to ocular surgery

  2024cites this paper
• From Multiscale Biophysics to Digital Twins of Tissues and Organs: Future Opportunities for in-silico Pharmacology

  2024cites this paper
• Computer modeling of bevacizumab drug distribution after intravitreal injection in rabbit and human eyes

  2024cites this paper
• From multiscale biophysics to digital twins of tissues and organs: future opportunities for in silico pharmacology

  2023cites this paper
• Advancing treatment of retinal disease through in silico trials

  2023cites this paper
• Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration

  2023cites this paper
• An Update on Strategies to Deliver Protein and Peptide Drugs to the Eye

  2023cites this paper
• Models and Algorithms for the Refinement of Therapeutic Approaches for Retinal Diseases

  2023influential citation
• Drug sustained release from degradable drug-loaded in-situ hydrogels in the posterior eye: A mechanistic model and analytical method.

  2022cites this paper
• Numerical Simulation and Analysis of the Temporal Concentration of Timolol after Topical Administration in the Human Eye

  2022cites this paper
• Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses

  2022cites this paper
• Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models

  2021cites this paper
• Computational modeling of intraocular drug delivery supplied by porous implants

  2021cites this paper
• Phacoemulsification and IOL-Implantation without Using Viscoelastics: Combined Modeling of Thermo Fluid Dynamics, Clinical Outcomes, and Endothelial Cell Density

  2021cites this paper
• Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration.

  2021cites this paper
• Analysis of topical dosing and administration effects on ocular drug delivery in a human eyeball model using computational fluid dynamics

  2021cites this paper
• In vitro and computational modelling of drug delivery across the outer blood–retinal barrier

  2020cites this paper
• Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

  2020cites this paper
• COMPUTATIONAL FLUID DYNAMICS FOR MODELING AND SIMULATION OF INTRAOCULAR DRUG DELIVERY AND WALL SHEAR STRESS IN PULSATILE FLOW

  2020cites this paper
• Preclinical challenges for developing long acting intravitreal medicines.

  2020cites this paper
• Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes

  2019cites this paper
• Gravity influences bevacizumab distribution in an undisturbed balanced salt solution in vitro

  2019cites this paper
• Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach

  2019cites this paper
• Physiologically based ocular pharmacokinetic modeling using computational methods.

  2019cites this paper
• Controlled release technology for anti‐angiogenesis treatment of posterior eye diseases: Current status and challenges

  2018influential citation
• Generation of an acute retinal photoreceptor degeneration model in rabbits.

  2018cites this paper
• A generalised porous medium approach to study thermo-fluid dynamics in human eyes

  2018cites this paper
• Penetration routes to retina and posterior segment

  2018cites this paper
• Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection

  2018cites this paper
• Modelling of retinal vasculature based on genetically tuned parametric L-system

  2018cites this paper
• Mathematical and numerical methods for modeling drug delivery to the posterior segment of the eye

  2017influential citation
• The PK-Eye: A Novel In Vitro Ocular Flow Model for Use in Preclinical Drug Development.

  2015cites this paper