The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts

The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H- 1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.

• Publication year

  1979

• Venue

  Journal of Experimental Medicine

• Publication date

  1979-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.149.1.244PMID 368285PMCID 2184738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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