Clonidine Induced Variations of Plasma Norepinephrine and Blood Pressure in Essential Hypertension

To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, clonidine induced variations of plasma norepinephrine, mean arterial pressure and the pulse rate three hours after a 300 μg dose of oral clonidine, an antihypertensive agent that decreases central sympathetic outflow, were studied. Baseline and clonidine suppressed plasma norepinephrine levels were not significantly different between the normal controls and patients with essential hypertension. The average plasma norepinephrine level, mean arterial pressure and pulse rate were significantly decreased from the baseline value in both normal control and essential hypertension (p<.005). The depressor response to sympathetic inhibition after clonidine were exaggerated in significant proportion in patients with essential hypertension compared to normal control group. Our study suggests that the pressor sensitivity to norepinephrine plays more important role than sympathetic overactivity in some patients with essential hypertension.

• Publication year

  1987

• Venue

  The Korean Journal of Internal Medicine

• Publication date

  1987-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3904/KJIM.1987.2.2.214PMID 3154833PMCID 4534933
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques.

  2009cited by this paper
• Clonidine-induced inhibition of sympathetic nerve activity: No indication for a central presynaptic or an indirect sympathomimetic mode of action

  2004cited by this paper
• Clonidine suppression testing in essential hypertension.

  1985cited by this paper
• Clonidine raises blood pressure in severe idiopathic orthostatic hypotension.

  1983cited by this paper
• Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man.

  1981cited by this paper
• Role of sympathetic nerve inhibition and body sodium-volume state in the antihypertensive action of clonidine in essential hypertension.

  1980cited by this paper
• Raised blood pressure and plasma noradrenaline concentrations in teenagers and young adults selected from an open population.

  1979cited by this paper
• Increased ratio between changes in blood pressure and plasma norepinephrine in essential hypertension.

  1979cited by this paper
• Sympathetic nervous system and blood-pressure control in essential hypertension.

  1978cited by this paper
• Age versus urinary sodium for judging renin, aldosterone, and catecholamine levels: studies in normal subjects and patients with essential hypertension.

  1978cited by this paper
• Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects.

  1977cited by this paper
• Bartter's syndrome results from an imbalance of vasoactive hormones.

  1977cited by this paper
• Mild high-renin essential hypertension. Neurogenic human hypertension?

  1977cited by this paper
• Increased plasma adrenaline concentrations in benign essential hypertension.

  1977cited by this paper
• Interrelations among blood pressure, blood volume, plasma renin activity and urinary catecholamines in benign essential hypertension.

  1977cited by this paper
• Facilitation of Adrenergic Transmission by Locally Generated Angiotensin II in Rat Mesenteric Arteries

  1976cited by this paper
• Circulating Catecholamine Levels in Human and Experimental Hypertension

  1976cited by this paper
• Plasma norepinephrine levels in essential hyoertension.

  1973cited by this paper
• Raised plasma-catecholamines in some patients with primary hypertension.

  1972cited by this paper
• A viewpoint concerning the enigma of hypertension.

  1972cited by this paper
• The haemodynamic consequences of adaptive structural changes of the resistance vessels in hypertension.

  1971cited by this paper
• V. CATECHOLAMINES CYCLIC AMP‐ANGIOTENSIN RECEPTORS: Plasma Catecholamine Concentrations in Patients with Hypertension

  1970cited by this paper
• Localization of the hypotenisve effect of 2-(2-6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155, Catapresan).

  1969cited by this paper
• PROLONGED INFUSIONS OF ANGIOTENSIN II AND NOREPINEPHRINE AND BLOOD PRESSURE, ELECTROLYTE BALANCE, AND ALDOSTERONE AND CORTISOL SECRETION IN NORMAL MAN AND IN CIRRHOSIS WITH ASCITES.

  1965cited by this paper

• No citing papers are available for this paper.