Temporal Predisposition to αβ and γδ T Cell Fates in the Thymus

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1102531PMID 22238456
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PreTCR and TCRγδ Signal Initiation in Thymocyte Progenitors Does Not Require Domains Implicated in Receptor Oligomerization

  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.

  2008cited by this paper
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  2007cited by this paper
• Key factors in the organized chaos of early T cell development

  2007cited by this paper
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  2006cited by this paper
• Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

  2006cited by this paper
• Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate

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• Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus.

  2006cited by this paper
• T‐cell development, doing it in a dish

  2006cited by this paper
• Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.

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• Visualization of the earliest steps of gammadelta T cell development in the adult thymus.

  2006cited by this paper
• Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.

  2005cited by this paper
• TCR Signal Strength Influences αβ/γδ Lineage Fate

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• TCR signal strength influences alphabeta/gammadelta lineage fate.

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• Mechanisms Controlling Termination of V-J Recombination at the TCRγ Locus: Implications for Allelic and Isotypic Exclusion of TCRγ Chains1

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  2005cited by this paper
• Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

  2005cited by this paper
• Early Expression of a Functional TCRβ Chain Inhibits TCRγ Gene Rearrangements without Altering the Frequency of TCRγδ Lineage Cells1

  2004cited by this paper
• Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt+ Cells

  2004cited by this paper
• Rates of Recombination and Chain Pair Biases Greatly Influence the Primary γδ TCR Repertoire in the Thymus of Adult Mice1

  2004cited by this paper
• Delayed and Restricted Expression Limits Putative Instructional Opportunities of Vγ1.1/Vγ2 γδ TCR in αβ/γδ Lineage Choice in the Thymus

  2004cited by this paper
• Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells.

  2004cited by this paper
• Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells.

  2004influential reference
• Rates of recombination and chain pair biases greatly influence the primary gammadelta TCR repertoire in the thymus of adult mice.

  2004cited by this paper
• Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus.

  2004cited by this paper
• The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

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• The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.

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• Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling

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• T Cell Development in TCRβ Enhancer-Deleted Mice: Implications for αβ T Cell Lineage Commitment and Differentiation1

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• Characterization of TCR gene rearrangements during adult murine T cell development.

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  1998cited by this paper
• Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes.

  1998cited by this paper
• A limited role for beta-selection during gamma delta T cell development.

  1998influential reference
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• On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment.

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• On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment

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• A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors.

  1998cited by this paper
• Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain.

  1997cited by this paper
• T cell receptor α gene rearrangement and transcription in adult thymic γδ cells

  1997cited by this paper
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  1997cited by this paper
• The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells

  1997cited by this paper
• αβ Lineage‐committed thymocytes can be rescued by the γδ T cell receptor (TCR) in the absence of TCR β chain

  1997cited by this paper
• Intrathymic δ Selection Events in γδ Cell Development

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• Intrathymic delta selection events in gammadelta cell development.

  1997cited by this paper
• Role of Different T Cell Receptors in the Development of Pre–T Cells

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• The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

  1996cited by this paper
• TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development.

  1996cited by this paper
• The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

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  1995cited by this paper
• ad1 and y8 T cells can share a late common precursor

  1995cited by this paper
• Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

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• Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

  1992cited by this paper
• Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.

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• T Cell Receptor – Instructed ␣ ␤ versus ␥ ␦ Lineage Commitment Revealed by Single-cell Analysis

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  2022cites this paper
• New insights into TCR β-selection.

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• Interaction between γδTCR signaling and the E protein‐Id axis in γδ T cell development

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• New Molecular Insights into Immune Cell Development.

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• Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development

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• Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space.

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• Enforcement of γδ-lineage commitment by the pre–T-cell receptor in precursors with weak γδ-TCR signals

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• Critical Role of TCR Specificity in the Development of V g 1 V d 6 . 3 + Innate NKT gd Cells

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  2013cites this paper
• Critical Role of TCR Specificity in the Development of Vγ1Vδ6.3+ Innate NKTγδ Cells

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• Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation

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