Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  British Journal of Anaesthesia

• Publication date

  1999-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/BJA/83.4.665PMID 10673890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of Action

  2000cited by this paper
• Effects of Intravenous General Anesthetics on [(3) H]GABA Release from Rat Cortical Synaptosomes

  1998cited by this paper
• Interactions between opioid drugs and propofol in laboratory models of seizures.

  1995cited by this paper
• Anesthetics Affect the Uptake but Not the Depolarization‐evoked Release of GABA in Rat Striatal Synaptosomes

  1995cited by this paper
• Anesthesia, 4th ed

  1995cited by this paper
• Molecular and cellular mechanisms of general anaesthesia

  1994cited by this paper
• General Anesthetics Potentiate ??-Aminobutyric Acid Actions on ??-Aminobutyric AcidA Receptors Expressed by Xenopus Oocytes: Lack of Involvement of Extracellular Calcium

  1993cited by this paper
• The general anesthetic potency of propofol and its dependence on hydrostatic pressure.

  1992cited by this paper
• General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium.

  1992cited by this paper
• Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.

  1991cited by this paper
• Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs.

  1982cited by this paper
• GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.

  1980cited by this paper

• From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

  2026cites this paper
• Integrated spatial and functional metabolic profiling identified the thick ascending limb as a mitochondrial vulnerability hub in acute kidney injury.

  2025cites this paper
• Functionalization of 1,3-Diisopropylbenzene to Probe the Antagonism of Propofol Anesthesia

  2025cites this paper
• Inhibition of Rac1 Attenuated Propofol-Induced Neurotoxicity in the Hippocampal Dentate Gyrus in Developing Mice

  2025cites this paper
• Ultrasound combined blood‐brain barrier targeting brain delivery of four‐in‐one molecular aggregates for the enhancement of anesthetic efficacy and toxicity reduction via propofol‐etomidate synergistically inhibition GABA receptor

  2024cites this paper
• Sedation with propofol and isoflurane differs in terms of microcirculatory parameters: A randomized animal study using dorsal skinfold chamber mouse model.

  2024cites this paper
• A Behavioral and Electroencephalographic Study of Anesthetic State Induced by MK-801 Combined with Haloperidol, Ketamine and Riluzole in Mice

  2024cites this paper
• Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo.

  2023cites this paper
• Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor

  2022cites this paper
• The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics

  2022cites this paper
• Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice

  2022cites this paper
• Effects of propofol on sleep architecture and sleep-wake systems in rats.

  2021cites this paper
• Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.

  2019cites this paper
• Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice.

  2019cites this paper
• Sepsis‐induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions

  2018cites this paper
• Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

  2018cites this paper
• Inhibitory effects of propofol on Th17 cell differentiation

  2017cites this paper
• Propofol inhibits T-helper cell type-2 differentiation by inducing apoptosis via activating gamma-aminobutyric acid receptor.

  2016cites this paper
• Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control

  2016cites this paper
• The Role of Dopaminergic VTA Neurons in General Anesthesia

  2015influential citation
• Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol.

  2015cites this paper
• Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.

  2014cites this paper
• Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System

  2013cites this paper
• DISSECTING THE REGISTRATION AND PROCESSING OF OLFACTORY EVENTS DURING GENERAL ANESTHESIA

  2011cites this paper
• Involvement of Tuberomamillary Histaminergic Neurons in Isoflurane Anesthesia

  2011cites this paper
• Propofol alters vesicular transport in rat cortical neuronal cultures.

  2011cites this paper
• Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression.

  2011cites this paper
• Modulation of AMPA receptor GluR1 subunit phosphorylation in neurons by the intravenous anaesthetic propofol.

  2008cites this paper
• Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature

  2007cites this paper
• Enhancement of Antitumor Immunity after Propofol Treatment in Mice

  2007cites this paper
• Mutation of α1G T-type Calcium Channels in Mice Does Not Change Anesthetic Requirements for Loss of the Righting Reflex and Minimum Alveolar Concentration but Delays the Onset of Anesthetic Induction

  2007cites this paper
• Propofol Inhibits Phosphorylation of N-methyl-d-aspartate Receptor NR1 Subunits in Neurons

  2006cites this paper
• Inhibition of neuronal nitric oxide synthase reduces the propofol requirements in wild‐type and nNOS knockout mice

  2006cites this paper
• Propofol and Midazolam Inhibit Gastric Emptying and Gastrointestinal Transit in Mice

  2004cites this paper
• A Neuronal Mechanism of Propofol-Induced Central Respiratory Depression in Newborn Rats

  2004cites this paper
• Propofol-Induced Anesthesia in Mice Is Mediated by &ggr;-Aminobutyric Acid-A and Excitatory Amino Acid Receptors

  2003cites this paper
• The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase

  2003cites this paper
• Inhibitory effect of propofol on ketamine‐induced c‐Fos expression in the rat posterior cingulate and retrosplenial cortices is mediated by GABAA receptor activation

  2003cites this paper
• Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.

  2002cites this paper
• Alpha-2 Adrenoceptor Activity Affects Propofol-Induced Sleep Time

  2002cites this paper
• High‐dose flumazenil potentiates the hypnotic activity of propofol, but not that of thiopental, in ddY mice

  2001cites this paper
• Beta-phenylethylamines and the isoquinoline alkaloids.

  2001cites this paper
• Evidence for GABAA Receptor Agonistic Properties of Ketamine: Convulsive and Anesthetic Behavioral Models in Mice

  2000cites this paper