Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00384.2014PMID 25924622PMCID PMC4490327
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms and biological functions of autophagy in diseased and ageing kidneys

  2015cited by this paper
• Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.

  2015cited by this paper
• Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

  2014cited by this paper
• APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.

  2014influential reference
• Gene-gene interactions in APOL1-associated nephropathy.

  2014cited by this paper
• 10th International Podocyte Conference, Freiburg, June 4-6, 2014: Abstracts

  2014cited by this paper
• Evolution of the primate trypanolytic factor APOL1

  2014cited by this paper
• Abstracts of the 10th International Podocyte Conference, June 4-6, 2014, Freiburg, Germany.

  2014cited by this paper
• Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation*

  2013cited by this paper
• The Innate Immune Factor Apolipoprotein L1 Restricts HIV-1 Infection

  2013cited by this paper
• The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

  2013cited by this paper
• Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy.

  2012cited by this paper
• Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease

  2012cited by this paper
• HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathologic characteristics

  2012cited by this paper
• APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis

  2012cited by this paper
• Emerging role of autophagy in kidney function, diseases and aging

  2012cited by this paper
• The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

  2012cited by this paper
• Absence of APOL1 Risk Variants Protects against HIV-Associated Nephropathy in the Ethiopian Population

  2011cited by this paper
• APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.

  2011cited by this paper
• TFEB Links Autophagy to Lysosomal Biogenesis

  2011cited by this paper
• Microautophagy of cytosolic proteins by late endosomes.

  2011cited by this paper
• Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.

  2010influential reference
• Alternative splicing and evolution: diversification, exon definition and function

  2010cited by this paper
• Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

  2010cited by this paper
• Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

  2010cited by this paper
• Methods in mammalian autophagy research.

  2010cited by this paper
• Nucleocytoplasmic Distribution and Dynamics of the Autophagosome Marker EGFP-LC3

  2010cited by this paper
• Non-productive HIV-1 infection of human glomerular and urinary podocytes.

  2010cited by this paper
• Association of Trypanolytic ApoL 1 Variants with Kidney Disease in African Americans

  2010cited by this paper
• Permeabilization of cell membranes.

  2010cited by this paper
• A Gene Network Regulating Lysosomal Biogenesis and Function

  2009cited by this paper
• Membrane Orientation of the Human Papillomavirus Type 16 E5 Oncoprotein

  2009cited by this paper
• In search of an “autophagomometer”

  2009cited by this paper
• The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions.

  2009cited by this paper
• Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

  2008cited by this paper
• Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.

  2008cited by this paper
• Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model

  2008cited by this paper
• Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death*

  2008cited by this paper
• ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death

  2008cited by this paper
• Alternative Isoform Regulation in Human Tissue Transcriptomes

  2008cited by this paper
• Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line

  2007cited by this paper
• Mammalian stress granules and processing bodies.

  2007cited by this paper
• Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

  2007cited by this paper
• Dynasore, a cell-permeable inhibitor of dynamin.

  2006cited by this paper
• The Emerging Role of

  2004cited by this paper
• Apolipoprotein L-I is the trypanosome lytic factor of human serum

  2003cited by this paper
• A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.

  2002influential reference
• The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.

  2002cited by this paper
• The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

  2001cited by this paper
• Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

  2001cited by this paper
• Use of Hoechst 33342 Staining To Detect Apoptotic Changes in Bovine Mononuclear Phagocytes Infected with Mycobacterium avium subsp. paratuberculosis

  2001cited by this paper
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper

• APOL1 plasma membrane pools resist rapid protein degradation

  2026cites this paper
• APOL1-associated kidney disease: modulators of the genotype-phenotype relationship

  2025cites this paper
• APOL1-mediated kidney disease: a narrative review of the lessons learnt from the past 15 years

  2025cites this paper
• Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms of Cell Injury

  2025cites this paper
• A Cell Biologist’s View on APOL1: What We Know and What We Still Need to Address

  2025cites this paper
• IFI16 Is Indispensable for Promoting HIF-1α-Mediated APOL1 Expression in Human Podocytes under Hypoxic Conditions

  2024cites this paper
• Apolipoprotein-L1 (APOL1): From Sleeping Sickness to Kidney Disease

  2024cites this paper
• Pathogenesis of HIV associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environmental interaction.

  2024cites this paper
• Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression

  2024cites this paper
• HIV-1 Nef acts in synergy with APOL1-G1 to induce nephrocyte cell death in a new Drosophila model of HIV-related kidney diseases

  2024cites this paper
• APOL1 nephropathy – a population genetics success story

  2024cites this paper
• A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

  2023cites this paper
• The Pathogenesis of African Trypanosomiasis.

  2022cites this paper
• Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier

  2022cites this paper
• Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys

  2021cites this paper
• Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity

  2021cites this paper
• Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects

  2021cites this paper
• The glomerular filtration barrier: a structural target for novel kidney therapies

  2021cites this paper
• The biofunctionalization of titanium nanotube with chitosan/genipin heparin hydrogel and the controlled release of IL-4 for anti-coagulation and anti-thrombus through accelerating endothelialization

  2021cites this paper
• Apolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties

  2021cites this paper
• Apolipoprotein L1 and mechanisms of kidney disease susceptibility

  2021cites this paper
• Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.

  2020cites this paper
• The Mechanism of Kidney Disease Due to APOL1 Risk Variants.

  2020cites this paper
• The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

  2020cites this paper
• APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

  2020cites this paper
• Gene of the month: APOL1

  2020cites this paper
• APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

  2020cites this paper
• Mechanisms of Injury in APOL1-associated Kidney Disease

  2019cites this paper
• Dilemmas and challenges in apolipoprotein L1 nephropathy research

  2019cites this paper
• Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton

  2019cites this paper
• Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu.

  2019cites this paper
• APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.

  2019cites this paper
• Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway

  2019cites this paper
• Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu

  2019cites this paper
• Apolipoprotein L1 Dynamics in Human Parietal Epithelial Cell Molecular Phenotype Kinetics

  2018cites this paper
• A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy

  2018cites this paper
• Fetal—Not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry

  2018cites this paper
• APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.

  2018cites this paper
• Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch

  2018cites this paper
• Molecular Mechanisms of Injury in HIV-Associated Nephropathy

  2018cites this paper
• APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It?

  2017cites this paper
• Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic lupus erythematosus patients

  2017cites this paper
• Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion.

  2017cites this paper
• APOL1 Nephropathy: A Population Genetics and Evolutionary Medicine Detective Story.

  2017cites this paper
• The Cell Biology of APOL1.

  2017cites this paper
• APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.

  2017cites this paper
• APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death.

  2017cites this paper
• ApoL1 Overexpression Drives Variant-Independent Cytotoxicity.

  2017cites this paper
• APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease.

  2016cites this paper
• Apolipoprotein L1 and Kidney Disease in African Americans.

  2016cites this paper
• Hypertension-attributed nephropathy: what's in a name?

  2016cites this paper
• Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort.

  2016cites this paper
• BH 3 domain-independent apolipoprotein L 1 toxicity rescued by BCL 2 prosurvival proteins

  2015cites this paper
• Protein domains of APOL1 and its risk variants.

  2015cites this paper
• BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins.

  2015cites this paper
• APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

  2015cites this paper
• Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression

  2015cites this paper