Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Oncogene

• Publication date

  2016-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2016.17PMID 26876215
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

  2014cited by this paper
• Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.

  2014cited by this paper
• Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (−) and ER (+) Breast Cancer

  2013cited by this paper
• Propofol suppresses proliferation, invasion and angiogenesis by down-regulating ERK-VEGF/MMP-9 signaling in Eca-109 esophageal squamous cell carcinoma cells.

  2013cited by this paper
• Lysophosphatidic acid enhances human hepatocellular carcinoma cell migration, invasion and adhesion through P38 MAPK pathway.

  2012cited by this paper
• Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

  2012cited by this paper
• Involvement of the Syk–mTOR pathway in follicular lymphoma cell invasion and angiogenesis

  2012cited by this paper
• Vascular endothelial growth factor A, secreted in response to transforming growth factor-β1 under hypoxic conditions, induces autocrine effects on migration of prostate cancer cells.

  2012cited by this paper
• Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer.

  2011cited by this paper
• PRSS3 promotes tumour growth and metastasis of human pancreatic cancer

  2010cited by this paper
• Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma

  2009cited by this paper
• The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells

  2009cited by this paper
• Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis

  2008cited by this paper
• The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching

  2008cited by this paper
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells.

  2008cited by this paper
• Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion.

  2007cited by this paper
• Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1

  2007cited by this paper
• Src phosphorylates Tyr284 in tgf-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion

  2007cited by this paper
• Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.

  2006cited by this paper
• Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.

  2006cited by this paper
• MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells

  2006cited by this paper
• Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.

  2006cited by this paper
• Decrease in the esophageal cancer incidence rate in mountainous but not level parts of Cixian County, China, over 29 years.

  2005cited by this paper
• Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.

  2005cited by this paper
• Autocrine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro

  2005cited by this paper
• Truncation of the projection domain of MAP4 (microtubule-associated protein 4) leads to attenuation of microtubule dynamic instability.

  2005cited by this paper
• The biology of VEGF and its receptors

  2003cited by this paper
• Esophageal cancer.

  2003cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis

  2002cited by this paper
• Clinical trials referral resource: Current clinical trials of the anti-VEGF monoclonal antibody bevacizumab.

  2001cited by this paper
• Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.

  2001cited by this paper
• Clinical trials referral resource: Current clinical trials of the anti-VEGF monoclonal antibody bevacizumab.

  2001cited by this paper
• Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.

  2000cited by this paper
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells*

  1998cited by this paper
• Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

  1998cited by this paper
• Wild-type p53 negatively regulates the expression of a microtubule-associated protein.

  1996cited by this paper
• Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics

  1995cited by this paper
• The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

  1993cited by this paper
• The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

  1992cited by this paper
• MAP 4: occurrence in mouse tissues

  1984cited by this paper

• Rufy3 Knockdown Induces PANoptosis Through MAP4/CDK1 Axis to Inhibit Colorectal Cancer Growth: Evidence From In Vitro and In Vivo Models

  2025cites this paper
• Cancer-metastasis-on-a-chip reveals efficacy of bevacizumab and siRNA in overcoming carboplatin resistance in SKOV3 ovarian cancer within a fibrotic metastatic microenvironment

  2025cites this paper
• THBS1 promotes angiogenesis and accelerates ESCC malignant progression by the HIF‐1/VEGF signaling pathway

  2024cites this paper
• cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer

  2024cites this paper
• A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

  2024cites this paper
• MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial–mesenchymal transition in lung adenocarcinoma

  2024cites this paper
• The emerging role of microtubules in invasion plasticity

  2023cites this paper
• The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer

  2023cites this paper
• Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells

  2023cites this paper
• The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases.

  2023cites this paper
• FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

  2023influential citation
• Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway

  2023cites this paper
• CBDCEM: An effective centrality based differential co-expression method for critical gene finding

  2022cites this paper
• Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules

  2021cites this paper
• Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor

  2021cites this paper
• STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma.

  2021cites this paper
• Advances and challenges in the treatment of esophageal cancer

  2021cites this paper
• The combination therapy of targeting both paclitaxel and Dendrophthoe pentandra leaves extract nanoparticles for improvement breast cancer treatment efficacy by reducing TUBB3 and MAP4 expressions.

  2021cites this paper
• Microtubule associated proteins as targets for anticancer drug development.

  2021cites this paper
• Susceptibility of cytoskeletal-associated proteins for tumor progression

  2021cites this paper
• Evaluating the effect of ovarian stimulation and exogenous progesterone on CD31-positive cell density, VEGF protein, and miR-17-5p expression of endometrium immediately before implantation.

  2020cites this paper
• Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4

  2020cites this paper
• Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3

  2020cites this paper
• Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway

  2020cites this paper
• The miR-1224-5p/TNS4/EGFR axis inhibits tumour progression in oesophageal squamous cell carcinoma

  2020cites this paper
• Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

  2020cites this paper
• Krill Oil Perturbs Proliferation and Migration of Mouse Colon Cancer Cells in vitro by Impeding Extracellular Signal-Regulated Protein Kinase Signaling Pathway.

  2020cites this paper
• IL-1RA controls the development of esophageal cancer by inhibition of VEGF via PI3K/NF-κB signaling pathway

  2019cites this paper
• Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation

  2019cites this paper
• Expression of Syk and MAP4 proteins in ovarian cancer

  2019cites this paper
• Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade

  2019cites this paper
• Microtubule-associated protein 4 phosphorylation regulates epidermal keratinocyte migration and proliferation

  2019cites this paper
• Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma

  2018cites this paper
• ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis

  2018cites this paper
• MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

  2017cites this paper
• Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.

  2017cites this paper
• eEF2K promotes progression and radioresistance of esophageal squamous cell carcinoma.

  2016cites this paper
• Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method.

  2016cites this paper
• XBP 1 induces MMP-9 expression to promote proliferation and invasion in human esophageal squamous cell carcinoma

  2016cites this paper
• Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation

  2016cites this paper
• XBP1 induces MMP-9 expression to promote proliferation and invasion in human esophageal squamous cell carcinoma.

  2016cites this paper
• Athymic nude mice as an experimental model for cancer treatment.

  2016cites this paper