Evolution of Ectopic Lymphoid Neogenesis and In Situ Autoantibody Production in Autoimmune Nonobese Diabetic Mice: Cellular and Molecular Characterization of Tertiary Lymphoid Structures in Pancreatic Islets

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Immunology

• Publication date

  2010-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1001836PMID 20713891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PREVENTION OF

  2013cited by this paper
• Prevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs

  2010cited by this paper
• AID and RPA: PKA makes the connection local

  2009cited by this paper
• The follicular versus marginal zone B lymphocyte cell fate decision

  2009cited by this paper
• Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.

  2009cited by this paper
• Data Sources for Improving Estimates of the Global Burden of Injuries: Call for Contributors

  2009cited by this paper
• Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

  2009cited by this paper
• Characterization of endothelial progenitor cells in the NOD mouse as a source for cell therapies

  2009cited by this paper
• Analysis of islet inflammation in human type 1 diabetes

  2009cited by this paper
• Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor α therapy in rheumatoid arthritis

  2008cited by this paper
• CD8+ T cells in type 1 diabetes.

  2008cited by this paper
• Ectopic lymphoid tissues and local immunity.

  2008cited by this paper
• CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjögren’s Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization1

  2008cited by this paper
• Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues

  2008influential reference
• Tertiary Lymphoid Structures in the Pancreas Promote Selection of B Lymphocytes in Autoimmune Diabetes1

  2007influential reference
• The biology of the germinal center.

  2007cited by this paper
• Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjögren’s Syndrome1

  2007cited by this paper
• Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse.

  2007cited by this paper
• Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells.

  2006cited by this paper
• Type 1 diabetes.

  2006cited by this paper
• Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure.

  2006cited by this paper
• Lymphoid neogenesis in chronic inflammatory diseases

  2006cited by this paper
• Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis.

  2006cited by this paper
• B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes.

  2006cited by this paper
• The NOD mouse: a model of immune dysregulation.

  2005cited by this paper
• Marginal zone B cells.

  2005cited by this paper
• Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.

  2005cited by this paper
• Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response.

  2005cited by this paper
• Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis

  2005cited by this paper
• Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome.

  2005cited by this paper
• Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.

  2004cited by this paper
• T-cell-dependent immune responses, germinal center development, and the analysis of V-gene sequences.

  2004cited by this paper
• Textbook Germinal Centers?1

  2004cited by this paper
• Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes.

  2004cited by this paper
• Textbook Germinal Centers?

  2004cited by this paper
• AID: how does it aid antibody diversity?

  2004cited by this paper
• Antibody diversity: one enzyme to rule them all

  2004cited by this paper
• The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity

  2003cited by this paper
• Extrafollicular antibody responses

  2003cited by this paper
• Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

  2003cited by this paper
• Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome.

  2003cited by this paper
• C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

  2003cited by this paper
• Organogenesis of lymphoid tissues

  2003influential reference
• The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self‐antigen‐specific immunoglobulin receptors

  2002cited by this paper
• Anatomic Localization of Immature and Mature Dendritic Cells in an Ectopic Lymphoid Organ: Correlation with Selective Chemokine Expression in Rheumatoid Synovium

  2002cited by this paper
• Marginal-zone B cells

  2002cited by this paper
• Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients1

  2001cited by this paper
• Ectopic Lymphoid Organogenesis A Fast Track for Autoimmunity

  2001cited by this paper
• T Cell Activation in Rheumatoid Synovium Is B Cell Dependent1

  2001cited by this paper
• "Lymphoid" chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjögren's syndrome patients: possible participation in lymphoid structure formation.

  2001cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Role of dendritic cells in the induction and maintenance of autoimmune diseases

  1999cited by this paper
• Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*

  1999cited by this paper
• Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and development.

  1999cited by this paper
• Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

  1999cited by this paper
• I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.

  1999cited by this paper
• Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

  1998cited by this paper
• B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice.

  1998cited by this paper
• B-Cells Are Required for the Initiation of Insulitis and Sialitis in Nonobese Diabetic Mice

  1997cited by this paper
• In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions

  1993cited by this paper
• The dynamic relationship between B-cell populations in adults.

  1993influential reference
• Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes

  1993cited by this paper
• Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes.

  1990cited by this paper
• The Animals (scientific procedures) Act 1986.

  1986cited by this paper
• Laboratory animal welfare; U.S. government principles for the utilization and care of vertebrate animals used in testing, research and training; notice.

  1985cited by this paper

• From Lymphotoxin to Tertiary Lymphoid Structures and Beyond

  2025cites this paper
• T-Cell Wars, A New Hope: Targeting Bcl6-Expressing T Cells in T1D.

  2025cites this paper
• Efineptakin alfa (NT-I7) improves overall survival and induces tertiary lymphoid structures in murine lung tumors

  2025cites this paper
• Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma

  2024cites this paper
• Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

  2024cites this paper
• Tertiary lymphoid structures in autoimmune diseases

  2024cites this paper
• Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

  2023cites this paper
• Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis

  2022cites this paper
• The Role of Interleukin-7 in the Formation of Tertiary Lymphoid Structures and Their Prognostic Value in Gastrointestinal Cancers

  2022cites this paper
• Autoantibodies as Biomarker and Therapeutic Target in Systemic Sclerosis

  2022cites this paper
• Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases

  2022cites this paper
• The Brave New World of Early Treatment of Multiple Sclerosis: Using the Molecular Biomarkers CXCL13 and Neurofilament Light to Optimize Immunotherapy

  2022cites this paper
• Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction

  2022cites this paper
• Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

  2021cites this paper
• Marginal zone B cells: From housekeeping function to autoimmunity?

  2021cites this paper
• Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

  2021cites this paper
• Biological mechanisms of ectopic lymphoid structure formation and their pathophysiological significance

  2020cites this paper
• Insulitis and lymphoid structures in the islets of Langerhans of a 66-year-old patient with long-standing type 1 diabetes

  2020cites this paper
• Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing.

  2020cites this paper
• Lymph node stromal cells: cartographers of the immune system

  2020cites this paper
• CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice

  2019cites this paper
• A proliferation inducing ligand (APRIL), une molécule, deux fonctions opposées dans l'autoimmunité

  2019cites this paper
• Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy

  2019cites this paper
• Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes

  2019cites this paper
• Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis

  2019cites this paper
• Characterization of ectopic lymphoid structures in different types of acute renal allograft rejection

  2018cites this paper
• Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development

  2018cites this paper
• T Cells That Help B Cells in Chronically Inflamed Tissues

  2018cites this paper
• Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations.

  2018cites this paper
• Cellular and Vascular Components of Tertiary Lymphoid Structures.

  2018cites this paper
• Tertiary Lymphoid Structures

  2018cites this paper
• Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures.

  2018cites this paper
• A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

  2018cites this paper
• Tertiary Lymphoid Structures: Autoimmunity Goes Local

  2018cites this paper
• High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

  2017cites this paper
• Autoimmunity and Inflammation

  2017cites this paper
• Spontaneous germinal centers and autoimmunity

  2017cites this paper
• Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

  2017cites this paper
• Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective?

  2017cites this paper
• BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis

  2017cites this paper
• Lupus Nephritis and Positions T Cells within the Glomeruli BAFF Induces Tertiary Lymphoid Structures

  2017cites this paper
• New Biological Avenues for Sjögren’s Syndrome

  2016cites this paper
• Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung

  2016cites this paper
• CD4 T cell differentiation in type 1 diabetes

  2016cites this paper
• Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation

  2016cites this paper
• Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

  2016cites this paper
• Evidence of perturbed germinal center dynamics, but preserved antibody diversity, in end‐stage renal disease

  2016cites this paper
• High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

  2016influential citation
• CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes.

  2016cites this paper
• Immunological Characterization of Intraocular Lymphoid Follicles in a Spontaneous Recurrent Uveitis Model.

  2016cites this paper
• 1 CXCR 3 , CXCR 5 , CXCR 6 , and CXCR 7 in Diabetes

  2016cites this paper
• Syddansk Universitet Evidence of perturbed germinal center dynamics , but preserved antibody diversity , in end-stage renal disease

  2016cites this paper
• Roles of Stromal Cells in the Immune System

  2016cites this paper
• Stromal Cells in Secondary Lymphoid Organs

  2016cites this paper
• Human B Cell Development and Tolerance

  2016cites this paper
• Spontaneous and Inducible Animal Models of Sjögren’s Syndrome

  2016cites this paper
• Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes

  2016cites this paper
• The pleomorphic role of stromal cells in the formation and maintenance of tertiary lymphoid organs

  2016cites this paper
• Stromal cells in chronic inflammation and tertiary lymphoid organ formation.

  2015cites this paper
• Development and description of a novel inducible model of salivary gland inflammation in C57BL/6 mice characterised by tertiary lymphoid structures, autoimmunity and exocrine dysfunction

  2015influential citation
• Contribution of autoallergy to the pathogenesis in the NOD mice

  2015cites this paper
• Unmasking the pathogenic role of IL-17 axis in primary Sjögren's syndrome: a new era for therapeutic targeting?

  2014cites this paper
• Myasthenia Gravis: paradox versus paradigm in autoimmunity.

  2014cites this paper
• Ectopic lymphoid-like structures in infection, cancer and autoimmunity

  2014cites this paper
• Lymphoid like stromal cells in a model of tertiary lymphoid organ formation

  2014cites this paper
• Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements

  2013cites this paper
• Early Differentiated CD138highMHCII+IgG+ Plasma Cells Express CXCR3 and Localize into Inflamed Kidneys of Lupus Mice

  2013cites this paper
• Apoptotic Regulation of B cell Development and Autoimmunity

  2013cites this paper
• CXCR5 EXPRESSING T HELPER CELLS MEDIATE PROTECTIVE IMMUNITY AGAINST TUBERCULOSIS

  2013cites this paper
• Memory B Cells in Mouse Models

  2013cites this paper
• B Cells in Autoimmune Diseases

  2012cites this paper
• Progress in pulmonary arterial hypertension pathology: relighting a torch inside the tunnel.

  2012cites this paper
• Intra‐islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

  2012cites this paper
• Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis.

  2012cites this paper
• Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice

  2012cites this paper
• A B cell explanation for autoimmune disease: the forbidden clone returns

  2012cites this paper
• This information is current as Inflammation in C 57 BL / 6 Mice a Novel Model of Salivary Gland Autoimmunity , and Exocrine Dysfunction in Inducible Tertiary Lymphoid Structures

  2012cites this paper
• B-cell selection and the development of autoantibodies

  2012cites this paper
• Tertiary lymphoid organs in infection and autoimmunity

  2012cites this paper
• Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies.

  2011cites this paper
• A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.

  2011influential citation
• The Ectopic Germinal Centre Response in Autoimmune Disease and Cancer

  2011cites this paper
• Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes.

  2011cites this paper