Molecular Imaging in Tumor Angiogenesis and Relevant Drug Research

Molecular imaging, including fluorescence imaging (FMI), bioluminescence imaging (BLI), positron emission tomography (PET), single-photon emission-computed tomography (SPECT), and computed tomography (CT), has a pivotal role in the process of tumor and relevant drug research. CT, especially Micro-CT, can provide the anatomic information for a region of interest (ROI); PET and SPECT can provide functional information for the ROI. BLI and FMI can provide optical information for an ROI. Tumor angiogenesis and relevant drug development is a lengthy, high-risk, and costly process, in which a novel drug needs about 10–15 years of testing to obtain Federal Drug Association (FDA) approval. Molecular imaging can enhance the development process by understanding the tumor mechanisms and drug activity. In this paper, we focus on tumor angiogenesis, and we review the characteristics of molecular imaging modalities and their applications in tumor angiogenesis and relevant drug research.

• Publication year

  2011

• Venue

  International Journal of Biomedical Imaging

• Publication date

  2011-07-25

• Fields of study

  Medicine, Chemistry, Computer Science

• Identifiers
  DOI 10.1155/2011/370701PMID 21808639PMCID 3144661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallmarks of cancer

  2012cited by this paper
• Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography

  2011cited by this paper
• Early detection of liver cancer based on bioluminescence tomography.

  2011cited by this paper
• Specific Targeting of Human Integrin αvβ3 with 111In-Labeled Abegrin™ in Nude Mouse Models

  2011cited by this paper
• Optical Imaging of Integrin αvβ3 Expression with Near-Infrared Fluorescent RGD Dimer with Tetra(ethylene glycol) Linkers

  2010cited by this paper
• 18F-Labeled Galacto and PEGylated RGD Dimers for PET Imaging of αvβ3 Integrin Expression

  2010cited by this paper
• Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers.

  2010cited by this paper
• Noninvasive imaging of tumor integrin expression using 18F-labeled RGD dimer peptide with PEG4 linkers

  2009cited by this paper
• Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation.

  2009cited by this paper
• 68Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin αvβ3 PET imaging

  2009cited by this paper
• Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers.

  2009cited by this paper
• In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells

  2008cited by this paper
• Integrin αvβ3‐targeted cancer therapy

  2008influential reference
• Molecular imaging in drug development

  2008cited by this paper
• Integrin alpha(v)beta(3)-Targeted Cancer Therapy.

  2008cited by this paper
• Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme

  2008cited by this paper
• A Novel Software Platform for Medical Image Processing and Analyzing

  2008cited by this paper
• The Role of Molecular Imaging in Drug Discovery and Development

  2008cited by this paper
• Reporter gene imaging of protein-protein interactions in living subjects.

  2007cited by this paper
• Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes

  2007cited by this paper
• [Molecular imaging for drug development].

  2007cited by this paper
• Current state of imaging protein-protein interactions in vivo with genetically encoded reporters.

  2007cited by this paper
• Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein-protein interactions.

  2007cited by this paper
• Optical Imaging: Current Applications and Future Directions

  2007cited by this paper
• Molecular imaging can accelerate anti-angiogenic drug development and testing

  2007cited by this paper
• Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel.

  2007cited by this paper
• Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism.

  2006cited by this paper
• A multilevel adaptive finite element algorithm for bioluminescence tomography.

  2006cited by this paper
• A highly sensitive protein-protein interaction assay based on Gaussia luciferase

  2006cited by this paper
• Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic mice.

  2006cited by this paper
• Anti-Angiogenic Cancer Therapy Based on Integrin αvβ3 Antagonism

  2006cited by this paper
• 99mTc-Labeled Cyclic RGDfK Dimer: Initial Evaluation for SPECT Imaging of Glioma Integrin αvβ3 Expression

  2006cited by this paper
• The added value of metabolic imaging with FDG-PET in oesophageal cancer: prognostic role and prediction of response to treatment

  2006cited by this paper
• How molecular imaging is speeding up antiangiogenic drug development

  2006cited by this paper
• An intramolecular folding sensor for imaging estrogen receptor–ligand interactions

  2006cited by this paper
• PET of vascular endothelial growth factor receptor expression.

  2006cited by this paper
• Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.

  2006cited by this paper
• 99mTc-labeled cyclic RGDfK dimer: initial evaluation for SPECT imaging of glioma integrin alphavbeta3 expression.

  2006cited by this paper
• Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors.

  2006cited by this paper
• Past, present, and future of annexin A5: from protein discovery to clinical applications.

  2005cited by this paper
• Multimodality tumor imaging targeting integrin alphavbeta3.

  2005cited by this paper
• Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.

  2005cited by this paper
• Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression

  2005cited by this paper
• Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals.

  2005cited by this paper
• Imatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma Membrane

  2005cited by this paper
• Multimodality tumor imaging targeting integrin α v β 3

  2005cited by this paper
• Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals.

  2004cited by this paper
• Molecular Imaging of Drug-Modulated Protein-Protein Interactions in Living Subjects

  2004cited by this paper
• Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor.

  2004cited by this paper
• In vivo molecular and genomic imaging: new challenges for imaging physics.

  2004cited by this paper
• Bioluminescent imaging of Cdk2 inhibition in vivo

  2004cited by this paper
• Tumor imaging by means of proteolytic activation of cell-penetrating peptides.

  2004cited by this paper
• Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals.

  2004cited by this paper
• Molecular imaging of homodimeric protein–protein interactions in living subjects

  2004cited by this paper
• Targeted In Vivo Labeling of Receptors for Vascular Endothelial Growth Factor

  2003cited by this paper
• MOLECULAR IMAGING IN DRUG DISCOVERY AND DEVELOPMENT

  2003cited by this paper
• Imaging 26S proteasome activity and inhibition in living mice

  2003cited by this paper
• Monitoring protein-protein interactions using split synthetic renilla luciferase protein-fragment-assisted complementation.

  2003cited by this paper
• Protease sensors for bioimaging

  2003cited by this paper
• Visualizing protein-protein interactions in living animals.

  2003cited by this paper
• Molecular imaging of cancer with positron emission tomography

  2002cited by this paper
• Molecular imaging in small animals—roles for micro‐CT

  2002cited by this paper
• Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis.

  2002cited by this paper
• Role of integrins in cell invasion and migration

  2002cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

  2002cited by this paper
• Noninvasive imaging of protein–protein interactions in living subjects by using reporter protein complementation and reconstitution strategies

  2002cited by this paper
• VEGF and the quest for tumour angiogenesis factors

  2002cited by this paper
• The development of [(124)I]iodinated-VG76e: a novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography.

  2002cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3

  2001cited by this paper
• In vivo optical imaging of expression of vascular endothelial growth factor following laser incision in skin

  2001cited by this paper
• Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging.

  1999cited by this paper
• MicroPET: a high resolution PET scanner for imaging small animals

  1996cited by this paper
• Practical cone-beam algorithm

  1984cited by this paper
• Methods in Enzymology , Vol

  1966cited by this paper

• Optical-CT Dual-Modality Mapping Base on DRR Registration

  2019cites this paper
• Biomedical Positron Emission Tomography (PET) imaging

  2014cites this paper
• Correlating Micro-CT Imaging with Quantitative Histology

  2012cites this paper
• Tumor endothelial markers as a target in cancer

  2012cites this paper
• In the Spotlight: Biomedical Signal Processing

  2011cites this paper
• In the Spotlight: Biomedical Signal Processing

  2010cites this paper