Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF

No abstract is available for this paper.

• Publication year

  2012

• Venue

  EMBO Reports

• Publication date

  2012-01-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/embor.2011.251PMID 22261717PMCID PMC3323138
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells.

  2010cited by this paper
• SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

  2010cited by this paper
• Customizing the targeting of IGF-1 receptor.

  2009cited by this paper
• Insulin and insulin-like growth factor signalling in neoplasia

  2008cited by this paper
• Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes

  2008cited by this paper
• Functional Significance of Type 1 Insulin-like Growth Factor-mediated Nuclear Translocation of the Insulin Receptor Substrate-1 and β-Catenin*

  2005cited by this paper
• Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

  2002cited by this paper
• Nuclear Translocation of Insulin Receptor Substrate-1 by the Simian Virus 40 T Antigen and the Activated Type 1 Insulin-like Growth Factor Receptor*

  2002cited by this paper
• In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

  2002cited by this paper
• Insulin-like Growth Factor-1 Induces Survival and Growth of Biologically Early Melanoma Cells through Both the Mitogen-activated Protein Kinase and β-Catenin Pathways

  2001cited by this paper
• IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition

  2001cited by this paper
• Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways.

  2001cited by this paper
• Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

  2001cited by this paper
• Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.

  2000cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

  1999cited by this paper
• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

  1999cited by this paper
• Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

  1998cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

  1997cited by this paper
• The IGF-I receptor in cell growth, transformation and apoptosis.

  1997cited by this paper
• Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

  1997cited by this paper
• Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells.

  1997cited by this paper
• The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis.

  1997cited by this paper
• Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

  1995cited by this paper
• Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System (*)

  1995cited by this paper
• Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.

  1994cited by this paper
• A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

  1992cited by this paper

• Matrix stiffness-induced NARF promotes hepatocellular carcinoma progression by enhancing LEF1-mediated transcription.

  2026cites this paper
• Site-Specific alterations in bone characteristics and mechanical properties in MYO9B-Deficient mice.

  2025cites this paper
• Detection of Genome‐Wide IGF‐1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers

  2025cites this paper
• Expression of IGF-1R in the Surface Epithelium Versus Invasive Front across Different Grades of Oral Squamous Cell Carcinoma: an Immunohistochemistry Analysis

  2025cites this paper
• The signaling landscape of insulin-like growth factor 1

  2024cites this paper
• IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

  2023cites this paper
• Targeting the IGF-Axis in Cultured Pediatric High-Grade Glioma Cells Inhibits Cell Cycle Progression and Survival

  2023cites this paper
• Drugging IGF-1R in cancer: New insights and emerging opportunities.

  2023cites this paper
• Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats

  2023cites this paper
• Immunohistochemical Expression of Insulin-Like Growth Factor-1 Receptor and Its Association with Clinicopathological Parameters in Hepatocellular Carcinoma

  2023cites this paper
• IGF-1R targeting in cancer – does sub-cellular localization matter?

  2023cites this paper
• The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities

  2023cites this paper
• Type 1 Insulin-Like Growth Factor Receptor Nuclear Localization in High-Grade Glioma Cells Enhances Motility, Metabolism, and In Vivo Tumorigenesis

  2022influential citation
• Hallmarks of cancer: The insulin-like growth factors perspective

  2022cites this paper
• Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition

  2022cites this paper
• Inhibition of insulin‐like growth factor‐1 receptor enhances eribulin‐induced DNA damage in colorectal cancer

  2022cites this paper
• Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy

  2022influential citation
• IGFBP‐3 functions as a molecular switch that mediates mitochondrial and metabolic homeostasis

  2021cites this paper
• Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

  2021cites this paper
• IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

  2021cites this paper
• The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer

  2021cites this paper
• Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach

  2021cites this paper
• Controlled Signaling—Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments

  2021cites this paper
• Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic Applications

  2021cites this paper
• Vorinostat triggers miR-769-5p/3p-mediated suppression of proliferation and induces apoptosis via the STAT3-IGF1R-HDAC3 complex in human gastric cancer.

  2021cites this paper
• The IGF-1 Signaling Pathway in Viral Infections

  2021cites this paper
• Nuclear IGF1R interacts with NuMA and regulates 53BP1-dependent DNA double-strand break repair in colorectal cancer

  2021cites this paper
• Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin

  2021cites this paper
• IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

  2021cites this paper
• The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis

  2021cites this paper
• The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease

  2020cites this paper
• New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations †

  2020influential citation
• Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: Transcriptional regulation and DNA damage response.

  2020cites this paper
• Nuclear receptor tyrosine kinase transport and functions in cancer.

  2020cites this paper
• Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

  2020cites this paper
• Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug

  2020cites this paper
• Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

  2019cites this paper
• Identification of nucleolar protein NOM1 as a novel nuclear IGF1R-interacting protein.

  2019cites this paper
• Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia

  2019cites this paper
• Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection.

  2019cites this paper
• Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells

  2019cites this paper
• The nuclear translocation of insulin‐like growth factor receptor and its significance in cancer cell survival

  2019cites this paper
• Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

  2019cites this paper
• Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/β-catenin signaling pathways.

  2018cites this paper
• Type 1 IGF Receptor Localization in Paediatric Gliomas: Significant Association with WHO Grading and Clinical Outcome

  2018cites this paper
• Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells

  2018cites this paper
• Role of IGF-1R in ameliorating apoptosis of GNE deficient cells

  2018cites this paper
• Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.

  2018cites this paper
• Mutual regulation between IGF‐1R and IGFBP‐3 in human corneal epithelial cells

  2018cites this paper
• Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI.

  2018cites this paper
• Novel functional role of GH/IGF-I in neonatal lung myofibroblasts and in rat lung growth after intrauterine growth restriction.

  2018cites this paper
• SUMO‐modified insulin‐like growth factor 1 receptor (IGF‐1R) increases cell cycle progression and cell proliferation

  2017cites this paper
• Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage

  2017cites this paper
• MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways

  2017cites this paper
• SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

  2017influential citation
• Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer

  2017cites this paper
• IGF-1 R regulates PCNA ubiquitination and DNA damage 1 Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage

  2017cites this paper
• IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

  2017cites this paper
• FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation

  2017cites this paper
• Fonctions nucléaires du récepteur de CSF-1 dans les monocytes humains

  2017cites this paper
• Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells

  2017cites this paper
• The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF‐1

  2017influential citation
• Etude de la voie d’action intracrine et nucléaire du Fibroblast Growth Factor 1 dans des cellules de type neuronal

  2016cites this paper
• The Multifaceted Actions of Leukaemia Inhibitory Factor in Mediating Uterine Receptivity and Embryo Implantation

  2016cites this paper
• The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer

  2016cites this paper
• Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein

  2016cites this paper
• Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy

  2016cites this paper
• Signalisation nucléaire de l'IGF-1R et résistance aux thérapies anti-EGFR dans les cancers du poumon

  2016cites this paper
• Insulin/Insulin-Like Growth Factors in Cancer: New Roles for the Aryl Hydrocarbon Receptor, Tumor Resistance Mechanisms, and New Blocking Strategies

  2015cites this paper
• Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

  2015cites this paper
• Nuclear translocation of fibroblast growth factor receptor 3 and its significance in pancreatic cancer.

  2015cites this paper
• Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution.

  2015cites this paper
• Nuclear Functions of Receptor Tyrosine Kinases

  2015cites this paper
• Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.

  2015cites this paper
• Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment

  2015cites this paper
• The Nucleus-Localized Epidermal Growth Factor Receptor Is SUMOylated.

  2015cites this paper
• Análise da expressão e do silenciamento do receptor tipo 1 do fator de crescimento semelhante à insulina em tumores adrenocorticais humanos

  2015cites this paper
• Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers

  2014cites this paper
• Nuclear translocation of IGF-1R via p150Glued and an importin-β/RanBP2-dependent pathway in cancer cells

  2014cites this paper
• From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells

  2014cites this paper
• The LIF-Mediated Molecular Signature Regulating Murine Embryo Implantation1

  2014cites this paper
• Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas

  2013cites this paper
• Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.

  2013cites this paper
• Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor

  2013cites this paper
• Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways

  2013cites this paper
• Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling

  2013cites this paper
• Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.

  2012cites this paper