Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Diabetes

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/DIABETES.51.11.3229PMID 12401714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pax4 regulatory elements mediate beta cell specific expression in the pancreas.

  2001cited by this paper
• Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

  2000cited by this paper
• Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas.

  2000cited by this paper
• Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.

  2000cited by this paper
• Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme

  2000cited by this paper
• Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

  2000cited by this paper
• Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

  1999cited by this paper
• Two transgenic approaches to define the cell lineages in endocrine pancreas development.

  1998cited by this paper
• Glucagon‐like peptide‐1 (GLP‐1): A gut hormone of potential interest in the treatment of diabetes

  1998cited by this paper
• Tissue-specific Expression of Unique mRNAs That Encode Proglucagon-derived Peptides or Exendin 4 in the Lizard*

  1997cited by this paper
• Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.

  1996cited by this paper
• Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors.

  1996cited by this paper
• Glucagon-like peptide-1 is a physiological incretin in rat.

  1995cited by this paper
• Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide.

  1995cited by this paper
• Developmental biology of the pancreas.

  1995cited by this paper
• Studies of Early Events in Pancreatic Organogenesis

  1994cited by this paper
• Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

  1993cited by this paper
• Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide.

  1993cited by this paper
• Onset of cell-specific gene expression in the developing mouse pancreas.

  1992cited by this paper
• Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

  1992cited by this paper
• Exendin-4, a new peptide from Heloderma suspectum venom, potentiates cholecystokinin-induced amylase release from rat pancreatic acini.

  1992cited by this paper
• Exendin peptides.

  1992cited by this paper
• Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene.

  1991cited by this paper
• Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.

  1988cited by this paper
• Glucagon metabolism in nonhuman primate pregnancy.

  1974cited by this paper
• Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon.

  1973cited by this paper
• Human placental barrier to 125-I-glucagon early in gestation.

  1972cited by this paper
• Failure of the human placenta to transfer pancreatic glucagon.

  1972cited by this paper
• The influence of extra-epithelial factors on the growth of embryonic mouse pancreatic epithelium.

  1968cited by this paper

• TGF-β signaling in pancreatic islet β cell development and function.

  2020cites this paper
• Anatomy, Physiology, and Embryology of the Pancreas

  2019cites this paper
• Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

  2018cites this paper
• Pancreas Embryology, Anatomy, and Physiology

  2018cites this paper
• Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival

  2018cites this paper
• Insulin Signaling in α-cells Modulates Glucagon Secretion in vivo

  2017cites this paper
• Using Morpholinos to Control Gene Expression

  2017cites this paper
• The Role of Prolactin Receptors in Regulation of Pancreatic Beta Cell Mass and Function

  2016cites this paper
• Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

  2016cites this paper
• An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration.

  2016cites this paper
• A synopsis of factors regulating beta cell development and beta cell mass

  2016influential citation
• Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.

  2016cites this paper
• Transcription factor regulation of pancreatic organogenesis, differentiation and maturation

  2016cites this paper
• glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

  2015cites this paper
• Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

  2015cites this paper
• The roles of pancreatic hormones in regulating pancreas development and beta cell regeneration

  2015influential citation
• The forgotten members of the glucagon family.

  2014cites this paper
• The regulation of pre- and post-maturational plasticity of mammalian islet cell mass

  2014cites this paper
• Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells

  2014cites this paper
• The ductal origin of structural and functional heterogeneity between pancreatic islets.

  2013cites this paper
• Targeting beta-cell apoptosis in diabetes: The role of mammalian Sterile Kinase 1 (MST1)

  2013influential citation
• Studies Of Regulated Exocytosis From Neuroendocrine Cells

  2013cites this paper
• Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor

  2013cites this paper
• Models of Regeneration of Beta Cells in Vivo

  2013cites this paper
• Reprogramming Adult Human Dermal Fibroblasts to Islet-Like Cells by Epigenetic Modification Coupled to Transcription Factor Modulation

  2013cites this paper
• Smad signaling pathways regulate pancreatic endocrine development.

  2013cites this paper
• DYNAMIC IMAGING OF INTRACELLULAR CA2+ CONCENTRATION IN INSULIN SECRETING MIN6 Β-CELLS USING WIDE FIELD AND TIRF MICROSCOPY

  2012cites this paper
• Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

  2012cites this paper
• Development and Regeneration in the Endocrine Pancreas

  2012cites this paper
• Development and Regeneration in the Endocrine Pancreas

  2012cites this paper
• Chapter 1A – Embryologic development of the liver, biliary tract, and pancreas

  2012cites this paper
• Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis

  2012cites this paper
• The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas

  2011cites this paper
• The CD34 surface antigen is restricted to glucagon-expressing cells in the early developing bovine pancreas

  2011cites this paper
• The role of decellularized matrix in directing differentiation of pancreatic progenitor cells in pancreatic endocrine cell fate.

  2011cites this paper
• Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

  2010cites this paper
• Endocrine-committed progenitor cells retain their differentiation potential in the absence of neurogenin-3 expression.

  2010cites this paper
• Production of a Type 2 Maternal Diabetes Rodent Model Using the Combination of High-Fat Diet and Moderate Dose of Streptozocin

  2010cites this paper
• High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice.

  2010cites this paper
• Pancreas and Islet Development

  2010cites this paper
• Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line.

  2010cites this paper
• Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction.

  2010cites this paper
• Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration

  2009cites this paper
• Improved Late-gestation Cardiac Morphology in Fetuses of Diabetic Mothers After Maternal Immune Stimulation: Potential Role of Dysregulated Apoptosis

  2009cites this paper
• Insulin signaling in alpha cells modulates glucagon secretion in vivo.

  2009cites this paper
• Pancreas cell fate.

  2009cites this paper
• Developmental biology of the pancreas: a comprehensive review.

  2009cites this paper
• MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.

  2009cites this paper
• Using Morpholinos to Control Gene Expression

  2008cites this paper
• The role of FOXM1 in pancreatic beta cell mass regeneration and expansion

  2008cites this paper
• The Reg Family Member INGAP Is a Marker of Endocrine Patterning in the Embryonic Pancreas

  2008cites this paper
• pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

  2008cites this paper
• Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

  2008cites this paper
• Imaging beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic beta cells

  2007cites this paper
• Early Expression of Adenosine 5′-Triphosphate-Gated P2X7 Receptors in the Developing Rat Pancreas

  2007cites this paper
• Pancreas development and beta-cell differentiation of embryonic stem cells.

  2007cites this paper
• Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology

  2007cites this paper
• Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.

  2007cites this paper
• Effect of photoperiod manipulation on rainbow trout (Oncorhynchus mykiss) egg quality: A genomic study

  2007cites this paper
• Cholecystokinin and gastrin receptors.

  2006cites this paper
• Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.

  2006cites this paper
• Using Morpholinos to Control Gene Expression

  2006influential citation
• Islet development: When glucagon's gone.

  2006cites this paper
• Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

  2006cites this paper
• Generation of pancreatic insulin-producing cells from embryonic stem cells — ‘Proof of principle’, but questions still unanswered

  2006cites this paper
• IA1 is NGN3‐dependent and essential for differentiation of the endocrine pancreas

  2006cites this paper
• Pancreas Development in Xenopus laevis

  2006cites this paper
• Essential Interaction of Egr-1 at an Islet-specific Response Element for Basal and Gastrin-dependent Glucagon Gene Transactivation in Pancreatic α-Cells*

  2005cites this paper
• Preclinical Trials for Stem Cell Therapy

  2005cites this paper
• Pancreatic differentiation.

  2005cites this paper
• Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland.

  2005cites this paper
• Stem cells in endocrinology

  2005cites this paper
• Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting.

  2004cites this paper
• Glucagon Promotes cAMP-response Element-binding Protein Phosphorylation via Activation of ERK1/2 in MIN6 Cell Line and Isolated Islets of Langerhans*

  2004cites this paper
• Development of pancreatic islets in pancreatic polypeptide-overexpressing mice.

  2004cites this paper
• [Pathophysiology of glucagon secretion].

  2004cites this paper
• The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors

  2004cites this paper
• Interplay of glucagon-like peptide-1 and transforming growth factor-beta signaling in insulin-positive differentiation of AR42J cells.

  2004cites this paper
• The Development of Beta-cell Mass: Recent Progress and Potential Role of GLP-1

  2004cites this paper
• Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes.

  2004cites this paper
• Purinergic signaling during rat embryonic development

  2004cites this paper
• Extracellular control of pancreatic differentiation.

  2004cites this paper
• Physiopathologie de la sécrétion du glucagon

  2004cites this paper
• Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

  2003cites this paper
• Current literature in diabetes

  2003cites this paper
• Current literature in diabetes.

  2003cites this paper
• Current literature in diabetes

  2001cites this paper