Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Cell Science

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.023911PMID 18716285PMCID PMC2661149
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CAP2, cyclase-associated protein 2, is a dual compartment protein

  2007cited by this paper
• Mechanism and biological role of profilin-Srv2/CAP interaction

  2007cited by this paper
• Actin-Induced Hyperactivation of the Ras Signaling Pathway Leads to Apoptosis in Saccharomyces cerevisiae

  2006influential reference
• Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast

  2005cited by this paper
• The actin cytoskeleton: a key regulator of apoptosis and ageing?

  2005cited by this paper
• The actin cytoskeleton in ageing and apoptosis.

  2005cited by this paper
• Regulation of Bcl-2 proteins during anoikis and amorphosis.

  2004cited by this paper
• Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells.

  2004cited by this paper
• A role for the actin cytoskeleton in cell death and aging in yeast

  2004cited by this paper
• β-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death

  2004influential reference
• Mitochondrial translocation of cofilin is an early step in apoptosis induction

  2003cited by this paper
• The oncogenicRAS2val19 mutation locks respiration, independently of PKA, in a mode prone to generate ROS

  2003cited by this paper
• Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1.

  2003cited by this paper
• C‐terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N‐myristoylated upon caspase‐mediated cleavage and targeted to mitochondria

  2003cited by this paper
• Cytochrome C-mediated apoptosis.

  2003cited by this paper
• Cyclase‐associated proteins: CAPacity for linking signal transduction and actin polymerization

  2002cited by this paper
• Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover.

  2002cited by this paper
• The expanding role of mitochondria in apoptosis.

  2001cited by this paper
• Human MCF10A Mammary Epithelial Cells Undergo Apoptosis following Actin Depolymerization That Is Independent of Attachment and Rescued by Bcl-2

  2001cited by this paper
• Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

  2001cited by this paper
• Anoikis mechanisms.

  2001cited by this paper
• Mammalian homolog of the yeast cyclase associated protein, CAP/Srv2p, regulates actin filament assembly.

  2000cited by this paper
• Association of Yeast Adenylyl Cyclase with Cyclase-Associated Protein CAP Forms a Second Ras-Binding Site Which Mediates Its Ras-Dependent Activation

  2000cited by this paper
• BCL-2 family members and the mitochondria in apoptosis.

  1999cited by this paper
• Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

  1999cited by this paper
• A Cytoskeletal Localizing Domain in the Cyclase-associated Protein, CAP/Srv2p, Regulates Access to a Distant SH3-binding Site*

  1999cited by this paper
• Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

  1999cited by this paper
• Coiled-coil Interaction of N-terminal 36 Residues of Cyclase-associated Protein with Adenylyl Cyclase Is Sufficient for Its Function in Saccharomyces cerevisiae Ras Pathway*

  1998cited by this paper
• Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

  1998cited by this paper
• Evidence for physical and functional interactions among two Saccharomyces cerevisiae SH3 domain proteins, an adenylyl cyclase-associated protein and the actin cytoskeleton.

  1997cited by this paper
• Cofilin promotes rapid actin filament turnover in vivo

  1997cited by this paper
• Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

  1996influential reference
• A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization

  1996cited by this paper
• Differential expression of CAP and CAP2 in adult rat tissues.

  1995cited by this paper
• An Actin Monomer Binding Activity Localizes to the Carboxyl-terminal Half of the Saccharomyces cerevisiae Cyclase-associated Protein (*)

  1995cited by this paper
• Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.

  1995cited by this paper
• Interactions between adenylyl cyclase, CAP and RAS from Saccharomyces cerevisiae.

  1994cited by this paper
• ASP‐56, a new actin sequestering protein from pig platelets with homology to CAP, an adenylate cyclase‐associated protein from yeast

  1992cited by this paper
• SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

  1990cited by this paper
• Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein.

  1990cited by this paper
• Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

  1988cited by this paper
• Inhibition of actin polymerization by latrunculin A

  1987cited by this paper

• N-terminal α-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis

  2025cites this paper
• Up-regulating methylation of CAP1 promoter can promote apoptosis and inhibit migration and invasion of lung adenocarcinoma cells

  2025cites this paper
• The Proliferation of Chang Liver Cells After Simulated Microgravity Induction

  2025cites this paper
• Extraction and identification of exosomes from three different sources of human ovarian granulosa cells and analysis of their differential miRNA expression profiles

  2024cites this paper
• An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives

  2024cites this paper
• Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis

  2024cites this paper
• Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors

  2023cites this paper
• Mechanism of the inhibitory effect of acupotomy on chondrocyte apoptosis in KOA rabbits explored via proteomics 运用蛋白质组学技术探讨针刀抗KOA兔软骨细胞凋亡的作用机制

  2023cites this paper
• Knockout of cyclase-associated protein CAP1 confers tolerance towards salt and osmotic stress in Arabidopsis.

  2023cites this paper
• CAP1 (cyclase-associated protein 1) mediates the cyclic AMP signals that activate Rap1 in stimulating matrix adhesion of colon cancer cells.

  2023cites this paper
• F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis

  2023cites this paper
• Mitochondria–actin cytoskeleton crosstalk in cell migration

  2022cites this paper
• Synaptic dysfunction in early phases of Alzheimer's Disease.

  2022cites this paper
• Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.

  2022cites this paper
• 1 intrinsic apoptosis 2 3 Running Title : Cytoskeletal control of apoptotic signaling 4 5 6

  2022cites this paper
• The cyclase-associated protein UvCap1 is required for mycelial growth and pathogenicity in the rice false smut fungus

  2021cites this paper
• Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration

  2021cites this paper
• The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis

  2021cites this paper
• Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain

  2020cites this paper
• Dendritic Spines in Alzheimer’s Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure

  2020cites this paper
• Role of cofilin-1 in arsenic trioxide-induced apoptosis of NB4-R1 cells

  2020cites this paper
• Functional Assay to Correlate Protein Oligomerization States with Membrane Pore Formation.

  2020cites this paper
• The Cytoskeletal Protein Cyclase-Associated Protein 1 (CAP1) in Breast Cancer: Context-Dependent Roles in Both the Invasiveness and Proliferation of Cancer Cells and Underlying Cell Signals

  2019cites this paper
• Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells

  2019cites this paper
• Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion

  2019cites this paper
• Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

  2019cites this paper
• Imaging of morphological and biochemical hallmarks of apoptosis with optimized optogenetic tools

  2019influential citation
• Adenylate Cyclase-Associated Protein 1 and Cofilin in Progression of Non-Small Cell Lung Cancer

  2019cites this paper
• Imaging of Morphological and Biochemical Hallmarks of Apoptosis with Optimized Optogenetic Actuators

  2019cites this paper
• A Novel Actin Binding Drug with In Vivo Efficacy

  2018influential citation
• CDK5 Functions as a Tumor Promoter in Human Lung Cancer

  2018cites this paper
• Occidiofungin, an actin binding antifungal with in vivo efficacy in a vulvovaginal candidiasis infection

  2018cites this paper
• The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation

  2018cites this paper
• Adenylyl cyclase-associated protein 1: Structure, regulation, and participation in cellular processes

  2018cites this paper
• Effects of resistin on platelet function and its receptor, adenylyl cyclase associated protein 1

  2017cites this paper
• DAMPs, endogenous danger signals fueling airway inflammation in COPD

  2017cites this paper
• Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection

  2017cites this paper
• Retrospective Proteomic Screening of 100 Breast Cancer Tissues

  2017cites this paper
• Methylmercury‐induced developmental toxicity is associated with oxidative stress and cofilin phosphorylation. Cellular and human studies

  2017cites this paper
• Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.

  2017cites this paper
• Novel roles of ADF/cofilins in maintenance of homeostasis in normal and malignant epithelial cells

  2017influential citation
• The Zuo Jin Wan Formula Induces Mitochondrial Apoptosis of Cisplatin-Resistant Gastric Cancer Cells via Cofilin-1

  2016cites this paper
• Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy

  2016cites this paper
• CAP1 (Cyclase-Associated Protein 1) Exerts Distinct Functions in the Proliferation and Metastatic Potential of Breast Cancer Cells Mediated by ERK

  2016cites this paper
• Cellular functions of the ADF/cofilin family at a glance

  2016cites this paper
• Actin dynamics and cofilin‐actin rods in alzheimer disease

  2016cites this paper
• Adenylyl cyclase-associated protein 1 in metastasis of squamous cell carcinoma of the head and neck and non-small cell lung cancer

  2016cites this paper
• Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

  2015cites this paper
• University of Birmingham Self-incompatibility-induced programmed cell death in field poppy pollen involves dramatic acidification of the incompatible pollen tube cytosol

  2015cites this paper
• Pathogenic microbes manipulate cofilin activity to subvert actin cytoskeleton

  2015cites this paper
• CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds.

  2015cites this paper
• Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis.

  2015cites this paper
• University of Birmingham Self-incompatibility-induced programmed cell death in field poppy pollen involves dramatic acidification of the incompatible pollen tube cytosol

  2015cites this paper
• Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2

  2015cites this paper
• Self-Incompatibility-Induced Programmed Cell Death in Field Poppy Pollen Involves Dramatic Acidification of the Incompatible Pollen Tube Cytosol1[OPEN]

  2015cites this paper
• CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation

  2015cites this paper
• Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid

  2014cites this paper
• Novel roles for actin in mitochondrial fission

  2014cites this paper
• Knocking down the expression of adenylate cyclase-associated protein 1 inhibits the proliferation and migration of breast cancer cells.

  2014cites this paper
• Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo

  2014cites this paper
• Cyclase associated protein 2:Roles in heart physiology and wound healing

  2014cites this paper
• Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.

  2014cites this paper
• Correction to: Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis

  2013cites this paper
• Establishment of human lymphoma cell lines with different thiopurine S-methyltransferase (TPMT) activities and differential proteome analysis after thiopurine exposure.

  2013cites this paper
• Mammalian CAP 1 ( adenylyl Cyclase-Associated Protein 1 ) Regulates Cofilin Function , the Actin Cytoskeleton and Cell Adhesion

  2013influential citation
• Mammalian Adenylyl Cyclase-associated Protein 1 (CAP1) Regulates Cofilin Function, the Actin Cytoskeleton, and Cell Adhesion*

  2013influential citation
• Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis

  2013influential citation
• The role of cyclase-associated protein in regulating actin filament dynamics – more than a monomer-sequestration factor

  2013cites this paper
• Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy

  2013cites this paper
• Proteins implicated in the increase of adhesivity induced by suberoylanilide hydroxamic acid in leukemic cells.

  2012cites this paper
• Elucidating the Role of Endothelin-2 (ET-2) in Inherited Photoreceptor Degenerations and the Indirect Effects of Systemic ET-2 Loss

  2012cites this paper
• Balancing life with glycoconjugates: Monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman spectroscopy

  2012cites this paper
• Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients

  2012cites this paper
• Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection

  2012cites this paper
• Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms

  2012cites this paper
• The Cyclase-Associated Protein Cap1 Is Important for Proper Regulation of Infection-Related Morphogenesis in Magnaporthe oryzae

  2012cites this paper
• Molecular and cellular pathobiology of Ehrlichia infection: targets for new therapeutics and immunomodulation strategies

  2011cites this paper
• Blood‐based biomarkers can differentiate ulcerative colitis from crohn's disease and noninflammatory diarrhea

  2011cites this paper
• Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization

  2011cites this paper
• Proteins implicated in mediating self-incompatibility-induced alterations to the actin cytoskeleton of Papaver pollen.

  2011cites this paper
• Actin-Binding Proteins Implicated in the Formation of the Punctate Actin Foci Stimulated by the Self-Incompatibility Response in Papaver1[W]

  2010cites this paper
• ADF/cofilin: a functional node in cell biology.

  2010cites this paper
• Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases

  2010cites this paper
• Running head: F-actin foci stimulated by SI

  2010cites this paper
• New insights into molecular Ehrlichia chaffeensis-host interactions.

  2010cites this paper
• Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

  2010cites this paper
• Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: lessons to be learned from the adenovirus E4orf4 death factor.

  2010cites this paper
• Loss of Cofilin 1 Disturbs Actin Dynamics, Adhesion between Enveloping and Deep Cell Layers and Cell Movements during Gastrulation in Zebrafish

  2010cites this paper
• Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study.

  2010cites this paper
• An Ehrlichia chaffeensis Tandem Repeat Protein Interacts with Multiple Host Targets Involved in Cell Signaling, Transcriptional Regulation, and Vesicle Trafficking

  2009cites this paper
• Investigating the role of the cytoskeleton and signalling in the self-incompatibility response of Papaver rhoeas.

  2009cites this paper