PEPTIDE ANALOGUES AS A STRATEGY TO INDUCE TOLERANCE IN T CELLS WITH INDIRECT ALLOSPECIFICITY1

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Transplantation

• Publication date

  2000-08-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00007890-200008270-00017PMID 10972222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling.

  1999cited by this paper
• Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides.

  1999cited by this paper
• Anergic T cells act as suppressor cells in vitro and in vivo

  1999cited by this paper
• Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells.

  1999cited by this paper
• Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35).

  1998cited by this paper
• Interferon-γ-treated renal tubular epithelial cells induce allospecific tolerance

  1998cited by this paper
• Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance.

  1998cited by this paper
• Linked suppression of skin graft rejection can operate through indirect recognition.

  1998cited by this paper
• Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

  1998cited by this paper
• Altered peptide ligand design: altering immune responses to class I MHC/peptide complexes

  1998cited by this paper
• Persistence of Peptide-induced CD4+ T cell Anergy In Vitro

  1998cited by this paper
• Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.

  1998cited by this paper
• Dissociation of Intracellular Signaling Pathways in Response to Partial Agonist Ligands of the T Cell Receptor

  1998cited by this paper
• Fine specificity of the myelin-reactive T cell repertoire: implications for TCR antagonism in autoimmunity.

  1998cited by this paper
• Altered peptide ligands act as partial agonists by inhibiting phospholipase C activity induced by myasthenogenic T cell epitopes.

  1998cited by this paper
• Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity.

  1998cited by this paper
• Variant antigenic peptide promotes cytotoxic T lymphocyte adhesion to target cells without cytotoxicity.

  1998cited by this paper
• Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity.

  1998cited by this paper
• A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low‐affinity ligands, but does not affect triggering by high‐affinity anti‐CD3 antibodies

  1997cited by this paper
• Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells.

  1997cited by this paper
• Indirect T-cell allorecognition: perspectives for peptide-based therapy in transplantation.

  1997cited by this paper
• A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens.

  1997cited by this paper
• Antigen presentation by interferon‐γ‐treated thyroid follicular cells inhibits interleukin‐2 (IL‐2) and supports IL‐4 production by B7‐dependent human T cells

  1997cited by this paper
• Anergic T cells effect linked suppression

  1997cited by this paper
• Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

  1997cited by this paper
• Allopeptide-specific T cell reactivity altered by peptide analogs.

  1997cited by this paper
• Altered Hapten Ligands Antagonize Trinitrophenyl-specific Cytotoxic T Cells and Block Internalization of Hapten-specific Receptors

  1997cited by this paper
• Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

  1996cited by this paper
• New approaches to specific immunomodulation in transplantation.

  1996cited by this paper
• Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands.

  1996cited by this paper
• The specificity and orientation of a TCR to its peptide-MHC class II ligands.

  1996cited by this paper
• Distinct conformations of a peptide bound to HLA-DR1 or DRB5*0101 suggested by molecular modelling.

  1996cited by this paper
• Indirect recognition of donor HLA-DR peptides in organ allograft rejection.

  1996cited by this paper
• Detection of donor-specific hyporesponsiveness following late failure of human renal allografts.

  1996cited by this paper
• Peptide analogs with different affinites for MHC alter the cytokine profile of T helper cells.

  1996cited by this paper
• Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells

  1996cited by this paper
• Antigen processing and presentation in transplantation.

  1996cited by this paper
• Partial signaling by CD8+ T cells in response to antagonist ligands

  1996cited by this paper
• T cell suppression in transplantation tolerance through linked recognition.

  1996cited by this paper
• Inhibition of experimental autoimmune myasthenia gravis by major histocompatibility complex class II competitor peptides results not only in a suppressed but also in an altered immune response

  1996cited by this paper
• Altered T cell receptor ligands trigger a subset of early T cell signals.

  1996cited by this paper
• Renal allograft rejection. Tubular epithelial cells present alloantigen in the presence of costimulatory CD28 antibody.

  1995cited by this paper
• Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

  1995cited by this paper
• Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

  1994cited by this paper
• Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo

  1994cited by this paper
• Antigen analogs/MHC complexes as specific T cell receptor antagonists.

  1994cited by this paper
• In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2.

  1994cited by this paper
• Th2 cell clonal anergy as a consequence of partial activation

  1994cited by this paper
• Anergic T cells as suppressor cells in vitro.

  1994cited by this paper
• A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

  1994cited by this paper
• Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance.

  1994cited by this paper
• T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

  1994cited by this paper
• Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.

  1994cited by this paper
• Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand.

  1994cited by this paper
• Contribution of direct and indirect recognition pathways to T cell alloreactivity

  1993cited by this paper
• Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity.

  1993cited by this paper
• Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands.

  1993cited by this paper
• B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance

  1993cited by this paper
• The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

  1993cited by this paper
• Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

  1993influential reference
• Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

  1993cited by this paper
• Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection

  1992cited by this paper
• Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor.

  1992influential reference
• In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells.

  1992cited by this paper
• Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides

  1992cited by this paper
• Studies on the human T cell receptor α/β variable region genes. II. Identification of four additional Vβ subfamilies

  1991cited by this paper
• Studies on the human T cell receptor alpha/beta variable region genes. II. Identification of four additional V beta subfamilies.

  1991cited by this paper
• Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand.

  1991cited by this paper
• A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

  1991cited by this paper
• Antigen presentation by keratinocytes induces tolerance in human T cells

  1990cited by this paper
• Interstitial dendritic cells.

  1990cited by this paper
• T cells sensitized to synthetic HLA-DR3 peptide give evidence of continuous presentation of denatured HLA-DR3 molecules by HLA-DP

  1989cited by this paper
• Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes

  1988cited by this paper
• T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• ANALYSIS OF THE ALLOREACTIVE T CELL REPERTOIRE IN MAN: I. DIFFERENCES IN PRECURSOR FREQUENCY FOR CYTOTOXIC T CELL RESPONSES AGAINST ALLOGENEIC MHC MOLECULES IN UNRELATED INDIVIDUALS

  1987cited by this paper
• High determinant density may explain the phenomenon of alloreactivity.

  1984cited by this paper
• Haplotype‐specific suppressor T cells mediating linked suppression of immune responses elicited by third‐party H‐2 alloantigens

  1983cited by this paper
• Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells

  1982cited by this paper
• Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain

  1981cited by this paper
• Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

  1977cited by this paper
• Renal allograft rejection.

  1975cited by this paper
• Renal allograft rejection.

  1971cited by this paper
• Renal allograft rejection.

  1968cited by this paper

• Clinical pharmacy service practice in a Chinese tertiary hospital

  2015cites this paper
• Allochimeric MHC I-Conditioned T Cells Attenuate Chronic Rejection in Rat Cardiac Model System

  2011cites this paper
• Clinical and immunological aspects of pretransplant blood transfusions

  2009cites this paper
• Intragraft Selection of the T Cell Receptor Repertoire by Class I MHC Sequences in Tolerant Recipients

  2009cites this paper
• Indirect Recognition of T‐Cell Epitopes Derived from the α3 and Transmembrane Domain of HLA‐A2

  2007cites this paper
• Indirect recognition of T-cell epitopes derived from the alpha 3 and transmembrane domain of HLA-A2.

  2007cites this paper
• Monitoring of indirect allorecognition: wishful thinking or solid data?

  2007cites this paper
• in vitro und nach Organtransplantation Characterization of immature rat bone marrow-derived dendritic cells : Evaluation of their phenotype and immunomodulatory properties in vitro and after organ transplantation

  2006cites this paper
• Prolongation of Cardiac Allograft Survival by Systemic Administration of Immature Recipient Dendritic Cells Deficient in NF-κB Activity

  2005cites this paper
• Self-peptide/MHC and TCR antagonism: physiological role and therapeutic potential.

  2005cites this paper
• Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus‐specific CD4+ T cell repertoire by favoring CD95‐mediated apoptosis

  2005cites this paper
• Allogeneic core amino acids of an immunodominant allopeptide are important for MHC binding and TCR recognition.

  2004cites this paper
• The Immunology of Allograft Rejection : A Survey of Current Knowledge and a Discussion of Peptide-Specific Anti-Rejection Strategies

  2004cites this paper
• HLA‐DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

  2004cites this paper
• HLA Peptide-mediated Strategies for Modulation of Cellular and Humoral Immune Response in Transplantation

  2003cites this paper
• Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo.

  2003cites this paper
• Modulation of the T cell response with MHC class I peptides and their analogues : perspectives for an antigen-specific therapy in transplantation

  2003cites this paper
• Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis.

  2002cites this paper
• Hierarchical immunogenicity of donor MHC class I peptides in allotransplantation.

  2002cites this paper
• TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation.

  2001cites this paper
• Studies With T Cell Lines and Clones and their Implications for the Understanding of Mechanisms in Pediatric Graft Rejection and Tolerance

  2001cites this paper
• Alloantigen recognition pathways and transplant tolerance.

  2001cites this paper
• T-cell anergy and peripheral T-cell tolerance.

  2001cites this paper
• The contributions of T‐cell anergy to peripheral T‐cell tolerance

  2001cites this paper