Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2003-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPENDO.00254.2002PMID 12531745
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility

  2004cited by this paper
• High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation.

  2003cited by this paper
• Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.

  2002cited by this paper
• Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats.

  2002cited by this paper
• IGF-I attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes.

  2002cited by this paper
• Overexpression of metallothionein reduces diabetic cardiomyopathy.

  2002cited by this paper
• Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts.

  2002cited by this paper
• α2‐Heremans Schmid glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction

  2002cited by this paper
• Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: role of nitric oxide and cyclic guanosine monophosphate signaling pathways.

  2002cited by this paper
• Diabetic alterations in cardiac sarcoplasmic reticulum Ca2+-ATPase and phospholamban protein expression.

  2001cited by this paper
• Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1

  2001cited by this paper
• Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction.

  2000cited by this paper
• Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats.

  2000cited by this paper
• Small guanine nucleotide-binding proteins and myocardial hypertrophy.

  2000cited by this paper
• Attenuated cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from biobreeding spontaneous diabetic rats.

  2000cited by this paper
• Altered cardiac excitation-contraction coupling in ventricular myocytes from spontaneously diabetic BB rats.

  2000cited by this paper
• Upregulation of rho A and rho kinase messenger RNAs in the basilar artery of a rat model of subarachnoid hemorrhage.

  2000cited by this paper
• Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats.

  1999cited by this paper
• Phospholamban-to-SERCA2 ratio controls the force-frequency relationship.

  1999cited by this paper
• Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease.

  1999cited by this paper
• Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes.

  1999cited by this paper
• Decrease in sodium-calcium exchange and calcium currents in diabetic rat ventricular myocytes.

  1999cited by this paper
• Alterations in the Growth Hormone-Insulin-Like Growth Factor Axis in Insulin Dependent Diabetes Mellitus

  1999cited by this paper
• Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles.

  1998cited by this paper
• Metabolic disturbances in diabetic cardiomyopathy

  1998cited by this paper
• Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+and NO.

  1998cited by this paper
• Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

  1998cited by this paper
• Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I.

  1998cited by this paper
• Altered inotropic response to IGF-I in diabetic rat heart: influence of intracellular Ca2+ and NO.

  1998cited by this paper
• Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation.

  1998cited by this paper
• Diabetic cardiomyopathy

  1998cited by this paper
• Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways*

  1997cited by this paper
• Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes.

  1997cited by this paper
• Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion.

  1997cited by this paper
• Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

  1996cited by this paper
• Troglitazone Attenuates High-Glucose–Induced Abnormalities in Relaxation and Intracellular Calcium in Rat Ventricular Myocytes

  1996cited by this paper
• Effects of diabetes on isometric tension as a function of [Ca2+] and pH in rat skinned cardiac myocytes.

  1995cited by this paper
• PI 3‐kinase: structural and functional analysis of intersubunit interactions.

  1994cited by this paper
• Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

  1994cited by this paper
• Relation of glycosylated hemoglobin to in vivo cardiac function in response to dobutamine in spontaneously diabetic BB Wor rats.

  1994cited by this paper
• In-vivo regulation of messenger RNA encoding insulin-like growth factor-I (IGF-I) and its receptor by diabetes, insulin and IGF-I in rat muscle.

  1992cited by this paper
• Diabetes-induced decrease in the mRNA coding for sarcoplasmic reticulum Ca(2+)-ATPase in adult rat cardiomyocytes.

  1991cited by this paper
• Diabetic Cardiomyopathy

  1990cited by this paper
• Ventricular relaxation of diabetic spontaneously hypertensive rat.

  1990cited by this paper
• Calmodulin-induced early-onset diabetes in transgenic mice.

  1989cited by this paper
• Diabetes and thyroid-hormone-induced changes in cardiac function and their molecular basis.

  1989cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Altered Myocardial Mechanics in Diabetic Rats

  1980cited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society In Vivo Insulin Signaling in the Myocardium of Streptozotocin-Diabetic Rats: Opposite Effects of Diabetes on Insulin Stimulation of Glycogen Synthase

  year unknowncited by this paper

• Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy

  2025cites this paper
• An updated review of YAP: A promising therapeutic target against cardiac aging?

  2023cites this paper
• Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process.

  2022cites this paper
• Effects of Exercise On Coronary Flow Reserve And Biochemical Parameters in Patients With Type 2 Diabetes Mellitus

  2022cites this paper
• Prokineticin 2 (PK2) Rescues Cardiomyocytes from High Glucose/High Palmitic Acid-Induced Damage by Regulating the AKT/GSK3β Pathway In Vitro

  2020influential citation
• UPREGULATION OF RYANODINE RECEPTOR CALCIUM CHANNELS (RYR2) IN RATS WITH INDUCED DIABETES AFTER 4 WEEKS OF HIGH INTENSITY INTERVAL TRAINING

  2016cites this paper
• Current Concepts in the Role of Mechanosensing in the Regulation of Cardiac Contractile Function

  2015cites this paper
• The insulin-like growth factor I system: physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome.

  2015cites this paper
• Animal Models of Diabetic Cardiomyopathy

  2015cites this paper
• Mechanosensing and Regulation of Cardiac Function

  2014cites this paper
• BMR Biotechnology-Protective mechanisms of rats heart in the acute phase of streptozotocin-induced diabetes in functional remodeling

  2014cites this paper
• Prokineticin Receptor‐1 Is a New Regulator of Endothelial Insulin Uptake and Capillary Formation to Control Insulin Sensitivity and Cardiovascular and Kidney Functions

  2013cites this paper
• Cardiomyocyte-specific p65 NF-κB deletion protects the injured heart by preservation of calcium handling.

  2013cites this paper
• Long-term administration of rosuvastatin prevents contractile and electrical remodelling of diabetic rat heart

  2013cites this paper
• Novel mechanistic insights into the role of advanced glycation end products in the development of diabetic cardiomyopathy

  2012cites this paper
• Sodium Tungstate Administration Ameliorated Diabetes-Induced Electrical and Contractile Remodeling of Rat Heart without Normalization of Hyperglycemia

  2012cites this paper
• Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca(2+) uptake via K(ATP) channel and PI3K/Akt pathway.

  2012cites this paper
• Myocardial AKT: the omnipresent nexus.

  2011cites this paper
• AKT-PKA INTERACTION IN THE MODULATION OF CARDIAC EXCITATION-CONTRACTION COUPLING

  2010cites this paper
• Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling

  2010cites this paper
• UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK.

  2009cites this paper
• Cardioprotection by vanadium compounds targeting Akt-mediated signaling.

  2009cites this paper
• Rodent models of diabetic cardiomyopathy

  2009cites this paper
• Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up‐regulation contribute to the onset of diabetic cardiomyopathy

  2009cites this paper
• Cardiac regulation by phosphoinositide 3-kinases and PTEN.

  2008cites this paper
• Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection.

  2008cites this paper
• IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction.

  2008cites this paper
• METALLOTHIONEIN AND CARDIOMYOPATHY

  2008cites this paper
• Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection

  2008cites this paper
• Impact of Insulin-like Growth Factor-I on Migration, Proliferation and Akt-ERK Signaling in Early and Late-passages of Vascular Smooth Muscle Cells

  2007cites this paper
• Differential protein expression in pancreatic islets after treatment with an imidazoline compound

  2007cites this paper
• Dietary Interaction of High Fat and Marginal Copper Deficiency on Cardiac Contractile Function

  2007cites this paper
• Chromium (d‐Phenylalanine)3 Improves Obesity‐Induced Cardiac Contractile Defect in ob/ob Mice

  2007cites this paper
• Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats

  2007cites this paper
• Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2.

  2007influential citation
• Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes

  2007cites this paper
• Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications.

  2007cites this paper
• Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility.

  2007cites this paper
• Cardiac overexpression of alcohol dehydrogenase (ADH) alleviates aging‐associated cardiomyocyte contractile dysfunction: role of intracellular Ca2+ cycling proteins

  2006cites this paper
• Original Contribution Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of Ca 2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme

  2006cites this paper
• diabetes mellitus contractile dysfunction in streptozotocin-induced High-dose benfotiamine rescues cardiomyocyte

  2006cites this paper
• Improvement in cardiac function of diabetic rats by bosentan is not associated with changes in the activation of PKC isoforms

  2006cites this paper
• Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice.

  2006influential citation
• Paradoxical effects of ginkgolide B on cardiomyocyte contractile function in normal and high-glucose environments

  2006cites this paper
• diabetes mellitus and metallothionein transgenic mice: the effect of Sex difference in cardiomyocyte function in normal

  2006cites this paper
• Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.

  2006cites this paper
• Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling

  2006cites this paper
• Sex difference in cardiomyocyte function in normal and metallothionein transgenic mice: the effect of diabetes mellitus.

  2006influential citation
• Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha.

  2006cites this paper
• Characterization of cardiomyocyte excitation-contraction coupling in the FVB/N-C57BL/6 intercrossed "chocolate" brown mice.

  2006cites this paper
• High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus.

  2006cites this paper
• Decreased cardiac sarcoplasmic reticulum Ca2+-ATPase activity contributes to cardiac dysfunction in streptozotocin-induced diabetic rats

  2006cites this paper
• Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes.

  2006cites this paper
• Metallothionein prolongs survival and antagonizes senescence‐associated cardiomyocyte diastolic dysfunction: role of oxidative stress

  2006cites this paper
• myocytes A-dependent pathway in murine ventricular protein contractile function via a protein kinase C- and Intermedin (adrenomedullin-2) enhances cardiac

  2006cites this paper
• Metallothionein antagonizes aging‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt

  2006cites this paper
• Small guanine nucleotide-binding protein Rho and myocardial function

  2005cites this paper
• Genetic modification of the heart: transgenic modification of cardiac lipid and carbohydrate utilization.

  2005cites this paper
• Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARγ and c-Jun

  2005influential citation
• Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function.

  2005cites this paper
• Characterization of mechanisms of myocardial remodeling in genetic models of cardiac hypertrophy

  2005cites this paper
• A new season of Chinese cardiovascular pharmacology research

  2005cites this paper
• Diabetic cardiomyopathy

  2004cites this paper
• Expression of liver insulin-like growth factor 1 gene and its serum level in patients with diabetes.

  2004cites this paper
• Heart failure—the importance of ethnicity

  2004cites this paper
• The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease.

  2004cites this paper
• Phytoestrogenic Isoflavones Daidzein and Genistein Reduce Glucose‐Toxicity‐Induced Cardiac Contractile Dysfunction in Ventricular Myocytes

  2004cites this paper
• Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes.

  2004influential citation
• Benefit and risk of exercise on myocardial function in diabetes.

  2003cites this paper
• Transgenic Overexpression of Insulin-like Growth Factor I Prevents Streptozotocin-induced Cardiac Contractile Dysfunction and -adrenergic Response in Ventricular Myocytes

  year unknowncites this paper