Serum levels of nitric oxide as a predictor of survival in acute respiratory distress syndrome caused by H1N1 pneumonia

A large number of studies show elevated levels of nitric oxide (NO) in infective syndromes, but there is an insufficient number of studies which have investigated serum levels of NO in patients with acute respiratory distress syndrome (ARDS), especially in relation to survival. Hence, we created a study with the aim of determining the NO levels in relation to ARDS survival. Serum levels of NO were measured by Griess reaction in 29 patients [16 men (55%), mean age years 52.72±18]. All data were statistically analyzed using one way ANOVA. Our results show significantly higher serum NO levels in ARDS survivors compared to ARDS non-survivors, (p < 0.05). We conclude that higher serum levels of NO are strongly associated with better clinical outcomes, including increased survival.

• Publication year

  2015

• Venue

  Signa Vitae

• Publication date

  2015-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.22514/SV101.042015.7
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute Respiratory Distress Syndrome The Berlin Definition

  2012cited by this paper
• The role of intrapulmonary nitric oxide generation in the development of adult respiratory distress syndrome

  2010cited by this paper
• From mechanical ventilation to intensive care medicine: a challenge for Bosnia and Herzegovina.

  2009cited by this paper
• Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.

  2007cited by this paper
• Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries

  2003cited by this paper
• High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.

  2003cited by this paper
• Exhaled breath condensate nitrite and its relation to tidal volume in acute lung injury.

  2003cited by this paper
• Opening the microcirculation: can vasodilators be useful in sepsis?

  2002cited by this paper
• Oxidant-antioxidant balance in acute lung injury.

  2002cited by this paper
• Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.

  2002cited by this paper
• Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome.

  2001cited by this paper
• Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury.

  2001cited by this paper
• Effect of nitrite on endothelial function in isolated lung.

  2000cited by this paper
• Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination.

  1999cited by this paper
• Measurement of nitrite and nitrate levels in plasma and urine--what does this measure tell us about the activity of the endogenous nitric oxide system?

  1998cited by this paper
• Expression of inducible nitric oxide synthase by macrophages in rat lung.

  1997cited by this paper
• Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS.

  1996cited by this paper
• Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome.

  1996cited by this paper
• Nitric oxide and septic shock.

  1996cited by this paper
• Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

  1995cited by this paper
• Clinical Investigations in Critical CareInflammatory Cytokines in the BAL of Patients With ARDS: Persistent Elevation Over Time Predicts Poor Outcome

  1995cited by this paper
• Nitric oxide synthases: roles, tolls, and controls.

  1994cited by this paper
• Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

  1994cited by this paper
• The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

  1994cited by this paper
• The L-arginine-nitric oxide pathway.

  1993cited by this paper
• Inflammation, immunoregulation, and inducible nitric oxide synthase

  1993cited by this paper
• Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.

  1983cited by this paper

• Nitric Oxide: The Missing Factor in COVID-19 Severity?

  2021cites this paper
• NOS+SARS-CoV-2 Pathogenesis

  2020cites this paper
• BIOMARKERS OF ACUTE RESPIRATORY DISTRESS SYNDROME: PROBLEMS AND PROSPECTS OF THEIR APPLICATION

  2019cites this paper