Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Experimental Cell Research

• Publication date

  2003-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-4827(02)00014-9PMID 12531698
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dimerization of Cell Surface Receptors in Signal Transduction Review

  2004cited by this paper
• Real-time kinetics of ligand/cell surface receptor interactions in living cells: binding of epidermal growth factor to the epidermal growth factor receptor.

  2001influential reference
• Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.

  2001influential reference
• An analytical approach to the measurement of equilibrium binding constants: application to EGF binding to EGF receptors in intact cells measured by flow cytometry.

  2001influential reference
• Epidermal Growth Factor (EGF) Receptor Kinase-independent Signaling by EGF*

  2001influential reference
• Take Your Partners

  2001cited by this paper
• Untangling the ErbB signalling network

  2001influential reference
• Tyrosine kinase-dependent, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma cells from anoikis.

  2001cited by this paper
• Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation.

  2000cited by this paper
• The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development.

  2000cited by this paper
• Epidermal Growth Factor Receptor Signal Transactivation

  2000cited by this paper
• Integrin α5/β1 Mediates Fibronectin-dependent Epithelial Cell Proliferation through Epidermal Growth Factor Receptor Activation

  2000cited by this paper
• Cell biology of lymphatic metastasis. The potential role of c-erbB oncogene signalling.

  2000cited by this paper
• Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1.

  2000cited by this paper
• The ErbB signaling network: receptor heterodimerization in development and cancer

  2000cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells*

  2000cited by this paper
• Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells*

  2000cited by this paper
• Constitutive Activation of JAK2 Confers Murine Interleukin-3-independent Survival and Proliferation of BA/F3 Cells*

  1999cited by this paper
• EGF receptor.

  1999cited by this paper
• Cellular survival: a play in three Akts.

  1999cited by this paper
• An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3′ Kinase-independent Survival Signaling Pathway in β Tumor Cells

  1999cited by this paper
• Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B.

  1999cited by this paper
• Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

  1999cited by this paper
• Modulation of cellular apoptotic potential: contributions to oncogenesis

  1999cited by this paper
• The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis.

  1999cited by this paper
• Epidermal growth factor receptors: critical mediators of multiple receptor pathways.

  1999cited by this paper
• An insulin-like growth factor-mediated, phosphatidylinositol 3' kinase-independent survival signaling pathway in beta tumor cells.

  1999cited by this paper
• Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases.

  1999cited by this paper
• Nucleotide-binding properties of kinase-deficient epidermal-growth-factor-receptor mutants.

  1998cited by this paper
• ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network

  1998influential reference
• Specificity within the EGF family/ErbB receptor family signaling network

  1998cited by this paper
• Mechanisms and consequences of activation of protein kinase B/Akt.

  1998cited by this paper
• The study of apoptotic cells by flow cytometry

  1998influential reference
• Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

  1998influential reference
• IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells

  1998cited by this paper
• The EGFR gene family in embryonic cell activities.

  1997cited by this paper
• Interleukin 3-dependent survival by the Akt protein kinase.

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Protein tyrosine kinases and cancer.

  1997cited by this paper
• ErbB Receptors and EGF-like Ligands: Cell Lineage Determination and Oncogenesis Through Combinatorial Signaling

  1997cited by this paper
• PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

  1997cited by this paper
• Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

  1996influential reference
• Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

  1995cited by this paper
• Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

  1995cited by this paper
• The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

  1995cited by this paper
• Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

  1995cited by this paper
• Strain-dependent epithelial defects in mice lacking the EGF receptor.

  1995cited by this paper
• An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-defective Epidermal Growth Factor Receptors (*)

  1995cited by this paper
• Dimerization of cell surface receptors in signal transduction.

  1995cited by this paper
• Receptor protein-tyrosine kinases and their signal transduction pathways.

  1994cited by this paper
• A kinase-negative epidermal growth factor receptor that retains the capacity to stimulate DNA synthesis.

  1994cited by this paper
• cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

  1994cited by this paper
• Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.

  1993cited by this paper
• Growth factor signaling by receptor tyrosine kinases.

  1992cited by this paper
• IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc.

  1992cited by this paper
• EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling.

  1990influential reference
• EGF induces differentiation of an IL‐3‐dependent cell line expressing the EGF receptor.

  1989cited by this paper
• Expression of functional human EGF receptor on murine bone marrow cells.

  1988cited by this paper
• Transfer of functional EGF receptors to an IL3‐dependent cell line

  1988cited by this paper
• Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells.

  1988cited by this paper
• Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.

  1987influential reference
• Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

  1987cited by this paper
• A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis

  1987cited by this paper
• Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

  1985cited by this paper
• Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

  1972cited by this paper

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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2016cites this paper
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  2015cites this paper
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  2014cites this paper
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  2011cites this paper
• EGFR-targeted Cancer Therapy: Promise, Problems and Potential Solutions

  2011cites this paper
• EGF-recruited JunD/c-fos complexes activate CD2AP gene promoter and suppress apoptosis in renal tubular epithelial cells.

  2009cites this paper
• A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

  2008cites this paper
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  2008cites this paper
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