Intersection of Pulmonary Hypertension and Right Ventricular Dysfunction in Patients on Left Ventricular Assist Device Support: Is There a Role for Pulmonary Vasodilators?

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Circulation: Heart Failure

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCHEARTFAILURE.117.004255PMID 29321132PMCID PMC7089581
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated.

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• Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device.

  2017cited by this paper
• The Relationship Between the Right Ventricle and its Load in Pulmonary Hypertension.

  2017cited by this paper
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• Hemodynamic Ramp Tests in Patients With Left Ventricular Assist Devices.

  2016cited by this paper
• Right ventricular afterload sensitivity dramatically increases after left ventricular assist device implantation: A multi-center hemodynamic analysis.

  2016cited by this paper
• Inhaled Milrinone After Left Ventricular Assist Device Implantation.

  2015cited by this paper
• Incidence and clinical significance of late right heart failure during continuous-flow left ventricular assist device support.

  2015cited by this paper
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• Pulmonary hypertension related to left heart disease: insight from a wireless implantable hemodynamic monitor.

  2015cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Right-ventricular failure following left ventricle assist device implantation

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Pulmonary hypertension due to left heart diseases.

  2013cited by this paper
• Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

  2013cited by this paper
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  2013cited by this paper
• Use of centrifugal left ventricular assist device as a bridge to candidacy in severe heart failure with secondary pulmonary hypertension.

  2013cited by this paper
• World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult--a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation.

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  2012cited by this paper
• Right ventricular failure after LVAD implantation: prevention and treatment.

  2012cited by this paper
• Right ventricular failure in patients with left ventricular assist devices.

  2012cited by this paper
• Contemporary Reviews in Cardiovascular Medicine Pulmonary Hypertension Due to Left Heart Disease

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• Transapical mitral valve in valve implantation

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• Pulmonary Hypertension Due to Left Heart Disease

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  2010cited by this paper
• Advanced heart failure treated with continuous-flow left ventricular assist device.

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  2008cited by this paper
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• Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure.

  2006cited by this paper
• Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates--2006.

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• The septal motor of biventricular function.

  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Overall cardiovascular profile of sildenafil citrate.

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