Expression of α-synuclein is increased in the hippocampus of rats with high levels of innate anxiety

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Psychiatry

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/mp.2008.43PMID 18427558
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct ventral and dorsal hippocampus AP5 anxiolytic effects revealed in the elevated plus-maze task in rats.

  2007cited by this paper
• Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.

  2007cited by this paper
• Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations.

  2007cited by this paper
• Levels of mRNA coding for α-, β- and γ-synuclein in the brains of newborn, juvenile, and adult rats

  2007cited by this paper
• Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats

  2007cited by this paper
• Social anxiety disorder in 300 patients hospitalized for alcoholism in Brazil: high prevalence and undertreatment.

  2006cited by this paper
• Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.

  2006cited by this paper
• Regulation of alpha‐synuclein expression in alcohol‐preferring and ‐non preferring rats

  2006cited by this paper
• Evidence for a female‐specific effect of a chromosome 4 locus on anxiety‐related behaviors and ethanol drinking in rats

  2006cited by this paper
• Anxiety and Hippocampus Volume in the Rat

  2006cited by this paper
• Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.

  2006cited by this paper
• Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.

  2006cited by this paper
• Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

  2006cited by this paper
• QTL mapping for traits associated with stress neuroendocrine reactivity in rats

  2005cited by this paper
• Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

  2005cited by this paper
• Anxiety disorders in Parkinson's disease.

  2005cited by this paper
• The relationship between social anxiety disorder and alcohol use disorders: a critical review.

  2005cited by this paper
• Common variations in the pretest environment influence genotypic comparisons in models of anxiety

  2005cited by this paper
• Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism.

  2005cited by this paper
• The association between stress and drinking: modifying effects of gender and vulnerability.

  2005cited by this paper
• α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells

  2005cited by this paper
• Expression of alpha-synuclein in different brain parts of adult and aged rats.

  2005cited by this paper
• Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving.

  2005cited by this paper
• Multiple regions of α‐synuclein are associated with Parkinson's disease

  2005cited by this paper
• Regional dissociations within the hippocampus--memory and anxiety.

  2004cited by this paper
• Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism.

  2004cited by this paper
• Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys.

  2004cited by this paper
• Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety.

  2004cited by this paper
• Pleiotropic effect of a locus on chromosome 4 influencing alcohol drinking and emotional reactivity in rats

  2003cited by this paper
• α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats

  2003cited by this paper
• Alcohol and psychiatric comorbidity.

  2003cited by this paper
• Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines.

  2003cited by this paper
• α-Synuclein

  2003cited by this paper
• Mapping of Rat Brain Using the Synuclein‐1 Monoclonal Antibody Reveals Somatodendritic Expression of α‐Synuclein in Populations of Neurons Homologous to those Vulnerable to Lewy Body Formation in Human Synucleopathies

  2003cited by this paper
• Analysis of quantitative trait loci that influence animal behavior.

  2003cited by this paper
• A role for alpha-synuclein in the regulation of dopamine biosynthesis.

  2002cited by this paper
• Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system.

  2002cited by this paper
• The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

  2002cited by this paper
• Marker‐assisted selection of a neuro‐behavioural trait related to behavioural inhibition in the SHR strain, an animal model of ADHD

  2002cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line*

  2002cited by this paper
• The UCH-L1 gene encodes two opposing enzymatic activities that affect-synuclein degradation and Park

  2002cited by this paper
• Evaluation of Lewis and SHR rat strains as a genetic model for the study of anxiety and pain.

  2002cited by this paper
• Immunohistochemical comparison of α- and β-synuclein in adult rat central nervous system

  2002cited by this paper
• A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

  2002cited by this paper
• Genetic basis of anxiety-like behaviour: a critical review.

  2002cited by this paper
• QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice.

  2001cited by this paper
• Molecular pathways of anxiety revealed by knockout mice

  2001cited by this paper
• QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice

  2001cited by this paper
• α-synuclein gene haplotypes are associated with Parkinson’s disease

  2001cited by this paper
• alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

  2001cited by this paper
• Behavioral genetics: anxiety under interrogation.

  2001cited by this paper
• Neuropathology in Mice Expressing Human α-Synuclein

  2000cited by this paper
• Mice Lacking a-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine

  2000cited by this paper
• Neuropathology in mice expressing human alpha-synuclein.

  2000cited by this paper
• Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.

  2000cited by this paper
• Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour.

  2000cited by this paper
• Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.

  2000cited by this paper
• Developmental expression of α-synuclein in rat hippocampus and cerebral cortex

  1999cited by this paper
• Identification of female-specific QTLs affecting an emotionality-related behavior in rats

  1999cited by this paper
• Anxiety: at the intersection of genes and experience

  1999cited by this paper
• Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortex.

  1999cited by this paper
• Alcohol and tension reduction

  1999cited by this paper
• Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia.

  1998cited by this paper
• Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

  1998cited by this paper
• Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

  1998cited by this paper
• A quantitative trait locus for alcohol consumption in selectively bred rat lines.

  1998cited by this paper
• alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

  1998cited by this paper
• α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

  1998cited by this paper
• Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

  1998cited by this paper
• Quantitative Trait Locus Analysis: A New Tool for Psychiatric Genetics

  1998cited by this paper
• Research report A genetic and multifactorial analysis of anxiety-related behaviours in Lewis and SHR intercrosses

  1998cited by this paper
• Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines

  1998cited by this paper
• Stress and emotionality: a multidimensional and genetic approach.

  1997influential reference
• A multiple-test study of anxiety-related behaviours in six inbred rat strains.

  1997cited by this paper
• Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13.

  1997cited by this paper
• Quantitative trait locus analysis of contextual fear conditioning in mice

  1997cited by this paper
• Quantitative trait loci analysis affecting contextual conditioning in mice

  1997cited by this paper
• Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats

  1995cited by this paper
• A simple genetic basis for a complex psychological trait in laboratory mice

  1995cited by this paper
• The prevalence of major anxiety disorders in relatives of alcohol dependent men and women.

  1995cited by this paper
• Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions.

  1994cited by this paper
• Alcohol dependence and anxiety disorders: what is the relationship?

  1994cited by this paper
• Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol.

  1993cited by this paper
• The rat brain synucleins; family of proteins transiently associated with neuronal membrane.

  1991cited by this paper
• Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.

  1990cited by this paper
• Thigmotaxis as a test for anxiolytic activity in rats.

  1988cited by this paper
• Open field and elevated plus-maze: a behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide.

  1987cited by this paper
• Psychological Theories of Drinking and Alcoholism

  1986cited by this paper
• The neuropsychology of anxiety: an enquiry into the functions of the Septo-Hippocampal system, Gray J.A.. Oxford University Press, New York (1981), pp. 523.,£27.50

  1983cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Transformation of rat cells by DNA of human adenovirus 5.

  1973cited by this paper
• Alcohol and tension reduction. A review.

  1972cited by this paper
• Alcoholism: theory, problem and challenge. II. Reinforcement theory and the dynamics of alcoholism.

  1956cited by this paper
• Alcoholism: Theory, problem and challenge.

  1956cited by this paper

• The Relationship between Anxiety, Depression-Like Behavior, and Arterial Pressure: A Comparative Study in 13-Month-Old Wistar, WKY, and SHR Rats

  2025cites this paper
• Comparative analysis of antioxidant status in Lewis and SHR inbreed rat strains.

  2025cites this paper
• Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies

  2023cites this paper
• Nuclear localization of alpha-synuclein induces anxiety-like behavior in mice by decreasing hippocampal neurogenesis and pathologically affecting amygdala circuits.

  2023cites this paper
• DIFFERENTIAL EXPRESSION OF ALPHA-SYNUCLEIN IN THE HIPPOCAMPUS OF SHR AND SLA16 ISOGENIC RAT STRAINS.

  2023cites this paper
• Sustained hyperactivity and lower blood pressure are influenced by the ANXRR16 chromosomic region in rats

  2023cites this paper
• Genetic effects in a progressive model of parkinsonism induced by reserpine

  2023cites this paper
• Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol

  2022cites this paper
• Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.

  2022cites this paper
• Chronic rapid eye movement sleep restriction during juvenility has long-term effects on anxiety-like behaviour and neurotransmission of male Wistar rats.

  2022cites this paper
• The influence of chromosome 4 on high ethanol consumption and blood pressure.

  2022cites this paper
• Altered Metabolism of the Microbiota–Gut–Brain Axis Is Linked With Comorbid Anxiety in Fecal Recipient Mice of Myasthenia Gravis

  2022cites this paper
• Fish Hydrolysate Supplementation Prevents Stress-Induced Dysregulation of Hippocampal Proteins Relative to Mitochondrial Metabolism and the Neuronal Network in Mice

  2022cites this paper
• Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps

  2022cites this paper
• Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and Spontaneously Hypertensive Rat (SHR): implications for cognitive deficits in a progressive animal model for Parkinson's Disease.

  2021cites this paper
• Neuroendocrine disruption by bisphenol A and/or di(2-ethylhexyl) phthalate after prenatal, early postnatal and lactational exposure

  2021cites this paper
• Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes

  2021cites this paper
• Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes

  2021cites this paper
• Purinergic P2Y1 and P2Y2/4 receptors elicit distinct Ca2+ signaling patterns in hepatocytes via differential feedback regulation by Protein Kinase C

  2020cites this paper
• Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT1A Receptor, and Adult Neurogenesis in Mice

  2020cites this paper
• The influence of chromosome 4 on metabolism and spatial memory in SHR and SLA16 rat strains.

  2019cites this paper
• Ethanol (EtOH)‐Related Behaviors in &agr;‐Synuclein Mutant Mice and Association of SNCA SNPs with Anxiety in EtOH‐Dependent Patients

  2018cites this paper
• Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice.

  2018cites this paper
• The Use of Object Recognition Task in Animal Models of Attention-Deficit Hyperactivity Disorder

  2018cites this paper
• Spontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson’s Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and α-Synuclein Expression

  2017cites this paper
• The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats

  2017cites this paper
• Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains.

  2017cites this paper
• Brain infusion of &agr;‐synuclein oligomers induces motor and non‐motor Parkinson’s disease‐like symptoms in mice

  2017cites this paper
• Anxiety-like behavior and dysregulation of miR-34a in triple transgenic mice of Alzheimer's disease.

  2016cites this paper
• Genetic evidence for chromosome 4 loci influencing learning and memory.

  2016cites this paper
• A comparison of the expression of α-synuclein mRNA in the brain of rats with different levels of alcohol consumption

  2016cites this paper
• Anxiolytic and neuroprotective effects of the Traditional Chinese Medicinal formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress.

  2016cites this paper
• Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior

  2015cites this paper
• The Modulatory Role of Dopamine in Anxiety-like Behavior.

  2015cites this paper
• The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects

  2014influential citation
• Investigação de elementos regulatórios do éxon 14 do gene Fmr1 e análise de expressão de suas isoformas

  2014cites this paper
• ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ В ПОВЕДЕНИИ, В СОДЕРЖАНИИ МОНОАМИНОВ, ИХ МЕТАБОЛИТОВ И В ПЛОТНОСТИ D1 И D2 ДОФАМИНОВЫХ РЕЦЕПТОРОВ В СТРУКТУРАХ МОЗГА У КРЫС ЛИНИИ WAG/Rij С ДЕПРЕССИВНОПОДОБНОЙ ПАТОЛОГИЕЙ

  2014cites this paper
• [Age-related changes in behavior, in monoamines and their metabolites content, and in density of D1 and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology].

  2014cites this paper
• Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity

  2013cites this paper
• Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way.

  2013cites this paper
• UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS DEPARTAMENTO DE BIOLOGIA CELULAR, EMBRIOLOGIA E GENÉTICA LABORATÓRIO DE GENÉTICA DO COMPORTAMENTO CURSO DE PÓS-GRADUAÇÃO EM FARMACOLOGIA

  2012cites this paper
• Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain.

  2012cites this paper
• The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption

  2011influential citation
• [Comorbidity between attention deficit/hyperactivity disorder and substance use disorders: evidence from animal models].

  2011cites this paper
• Lack of involvement of alpha-synuclein in unconditioned anxiety in mice.

  2010cites this paper
• Altered Affect, Monoamine Transmitters and Bioenergetic Homeostasis of Alpha-Synuclein-Transgenic Mice, in the Presence and Absence of Endogenous Alpha-Synuclein

  2010cites this paper
• Rat genomics applied to psychiatric research.

  2010cites this paper
• Comorbidity between attention deficit/hyperactivity disorder and substance use disorders: evidence from animal models

  2010cites this paper
• Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization.

  2010cites this paper
• Drug reinforcement in a rat model of attention deficit/hyperactivity disorder--the Spontaneously Hypertensive Rat (SHR).

  2009cites this paper