Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions (CA1- 3) between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia. p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group. p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

• Publication year

  2015

• Venue

  Neural Regeneration Research

• Publication date

  2015-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4103/1673-5374.158359PMID 26199612PMCID 4498357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
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  2014influential reference
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  2000influential reference
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• Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration.

  2000cited by this paper
• The p53 pathway

  1999cited by this paper
• Inflammation and glial responses in ischemic brain lesions.

  1998influential reference
• Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death.

  1998cited by this paper
• Hippocampal Myc and p53 expression following transient global ischemia.

  1998influential reference
• p53, the Cellular Gatekeeper Review for Growth and Division

  1997cited by this paper
• Cerebral ischemia in young and adult gerbils: effects on cholinergic metabolism.

  1996cited by this paper
• Resistance to Cerebral Ischemia in Developing Gerbils

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• Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor

  1995cited by this paper
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• Delayed hippocampal damage in humans following cardiorespiratory arrest

  1987cited by this paper
• Selective neuronal vulnerability: morphological and molecular characteristics.

  1985cited by this paper
• Delayed neuronal death in the gerbil hippocampus following ischemia.

  1982cited by this paper

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