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Anesthesia and the heart.

Muir Ww

Published 1977 in Journal of the American Veterinary Medical Association

ABSTRACT

Drugs that have the capability of depressing the central nervous system enough to be used as anesthetics or preanesthetic agents generally depress cardiac performance. Besides their obvious indirect (neural) modification of cardiac function, many anesthetics demonstrate direct activity in modulating hemodynamics, myocardial blood flow and oxygenation, and myocardial energy supply and utilization. Reflex responses to these modifications often lead to physiologic alterations that may or may not be beneficial to the animal. In this light, drugs that are known to possess direct depressant effects on heart muscle may display indirect or reflex benefits when administered to the clinical patient. Consequently, the interpretation of both preanesthetic or anesthetic drug activity depends on the conditions of the experiment or, in the case of clinical patients on current physiologic status. The variability and complexity of effects of anesthetics on cardiac function are to a large extent dose dependent; therefore, only the cardiac effects of clinically acceptable dosages will be considered.

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