Actions of oxytocin and a long-acting carba oxytocin analog on the porcine myometrium in vitro and in vivo.

The contractile actions of oxytocin and its analog 1-desamino-1-monocarba-[2-Tyr(OMe)]-oxytocin were compared on in vitro (experiment 1) and in vivo (experiment 2) preparations of porcine uterine horns. In both experiments, sows in estrus were selected for maximal sensitivity. Despite the loss of peak amplitude associated with the substitution at sequence position 2 of O-methyltyrosine for tyrosine, the two remaining alterations (N-terminal desamination and replacement of the 1-6 S-S bridge by CH2S) prolonged the action of single-dose presentations. Thus, instead of having a response lasting minutes when the parent hormone is given, an IV dose of about 5 micrograms of the analog/kg of body weight in the intact anesthetized sow resulted in a response lasting two hours.

• Publication year

  1979

• Venue

  American Journal of Veterinary Research

• Publication date

  1979-03-01

• Fields of study

  Biology, Agricultural and Food Sciences, Medicine, Chemistry

• Identifiers
  DOI 10.2460/ajvr.1979.40.03.430PMID 475101
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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