Corticosteroid Treatment for Central Nervous System Infections

Infectious diseases of the central nervous system (CNS) cause inflammatory processes within the brain and spinal cord that can lead to morbidity and mortality in a high proportion of patients. Pharmacological strategies to dampen inflammation have been investigated, and steroids are one of the adjunctive treatments for bacterial meningitis, tuberculous meningitis, and herpes simplex virus encephalitis. In this paper, we review the recent literature that provides guidelines for the use of steroids in combination with appropriate antimicrobial therapy, and we discuss how systemic steroid treatment is an important aspect of treatment regimens for CNS infectious diseases. J Neurocrit Care 2017;10(2):69-75

• Publication year

  2017

• Venue

  Unknown venue

• Publication date

  2017-12-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.18700/JNC.170024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Epidemiological Profile of Acute Viral Encephalitis

  2018cited by this paper
• ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.

  2016cited by this paper
• The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults.

  2016cited by this paper
• Corticosteroids for acute bacterial meningitis.

  2015cited by this paper
• A Systematic Review on the Role of Adjunctive Corticosteroids in Herpes Simplex Virus Encephalitis: Is Timing Critical for Safety and Efficacy?

  2014cited by this paper
• Epidemiology of bacterial meningitis in the USA from 1997 to 2010: a population-based observational study.

  2014cited by this paper
• Diagnosis and Treatment of Tuberculous Meningitis

  2014cited by this paper
• The role of dexamethasone in the treatment of bacterial meningitis – a systematic review

  2012cited by this paper
• Experimental herpes simplex virus encephalitis: A combination therapy of acyclovir and glucocorticoids reduces long-term magnetic resonance imaging abnormalities

  2011cited by this paper
• Case report: a pregnant woman with herpes simplex encephalitis successfully treated with dexamethasone.

  2011cited by this paper
• Changing etiology of community-acquired bacterial meningitis in adults: a nationwide multicenter study in Korea

  2010cited by this paper
• Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis.

  2009cited by this paper
• Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.

  2008cited by this paper
• CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure.

  2008cited by this paper
• Steroids for deteriorating herpes simplex virus encephalitis.

  2007cited by this paper
• Predictors of long‐term neurological sequelae of tuberculous meningitis: a multivariate analysis

  2007cited by this paper
• An Update on the Diagnosis of Adrenal Insufficiency and the Use of Corticotherapy in Critical Illness

  2007cited by this paper
• Emergency diagnosis and treatment of adult meningitis.

  2007cited by this paper
• Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice.

  2007cited by this paper
• Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis.

  2007cited by this paper
• Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study.

  2007cited by this paper
• Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa.

  2007cited by this paper
• Advances in pathogenesis and management of sepsis

  2007cited by this paper
• Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series.

  2006cited by this paper
• Community-acquired bacterial meningitis in adults.

  2006cited by this paper
• Dexamethasone and long‐term outcome in adults with bacterial meningitis

  2006cited by this paper
• Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults

  2006cited by this paper
• Dexamethasone in adults with community-acquired bacterial meningitis.

  2006cited by this paper
• Herpes simplex encephalitis: adolescents and adults.

  2006cited by this paper
• Dexamethasone for treatment of tuberculous meningitis in adolescents and adults

  2005cited by this paper
• Tuberculous meningitis: many questions, too few answers.

  2005cited by this paper
• Evaluation of combination therapy using aciclovir and corticosteroid in adult patients with herpes simplex virus encephalitis

  2005cited by this paper
• Clinical features and prognostic factors in adults with bacterial meningitis.

  2004cited by this paper
• Herpes simplex (HSV-1) aseptic meningitis.

  2004influential reference
• Practice guidelines for the management of bacterial meningitis.

  2004cited by this paper
• Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's.

  2004cited by this paper
• Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis

  2004cited by this paper
• Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock

  2003cited by this paper
• Beneficial Effect of Steroid Pulse Therapy on Acute Viral Encephalitis

  2003cited by this paper
• Dexamethasone in adults with bacterial meningitis.

  2003cited by this paper
• Management of bacterial meningitis in adults

  2003cited by this paper
• Pathogenesis and pathophysiology of pneumococcal meningitis.

  2002cited by this paper
• Treatment of bacterial meningitis

  2002cited by this paper
• Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury.

  2002cited by this paper
• Dexamethasone in adults with bacterial meningitis

  2002cited by this paper
• Viral infections of the CNS with special emphasis on herpes simplex infections

  2001cited by this paper
• Changing epidemiology of bacterial meningitis in the United States

  2000cited by this paper
• Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In VitroAnalysis of Inflammation-Induced Secondary Injury after CNS Trauma

  1999cited by this paper
• Dexamethasone as Adjunctive Therapy in Bacterial Meningitis. A Meta-Analysis of Randomized Clinical Trials Since 1988

  1997cited by this paper
• Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis.

  1997cited by this paper
• Bacterial Meningitis in the United States in 1995

  1997cited by this paper
• The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis.

  1996cited by this paper
• Steroid controversy in sepsis and septic shock: a meta-analysis.

  1995cited by this paper
• Randomized controlled trial of dexamethasone in tuberculous meningitis.

  1994cited by this paper
• Encephalitis in immunocompetent patients due to herpes simplex virus type 1 or 2 as determined by type‐specific polymerase chain reaction and antibody assays of cerebrospinal fluid

  1993cited by this paper
• Dexamethasone adjunctive treatment for tuberculous meningitis.

  1991cited by this paper
• Experimental herpes simplex virus encephalitis. Effect of corticosteroids and pyrimidine nucleoside.

  1976cited by this paper
• The treatment of purulent meningitis with adrenal cortico-steroids.

  1962cited by this paper
• Herpes simplex virus.

  1961cited by this paper
• ACTH and adrenal steroids in the treatment of pneumococcal meningitis in adults.

  1958cited by this paper
• Tuberculous meningitis treated with cortisone.

  1955cited by this paper
• Tuberculous meningitis: combined therapy with cortisone and antimicrobial agents.

  1953cited by this paper

• Protopanaxadiol Derivative: A Plant Origin of Novel Selective Glucocorticoid Receptor Modulator with Anti-inflammatory Effect.

  2024cites this paper
• Anti-inflammatory effect of Salsola komarovii extract with dissociated glucocorticoid activity

  2020cites this paper