Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

No abstract is available for this paper.

• Publication year

  2010

• Venue

  EMBO Journal

• Publication date

  2010-04-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2010.28PMID 20300065PMCID PMC2868569
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.

  2009cited by this paper
• The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors

  2009cited by this paper
• A protein complex that regulates PtdIns(3,5)P2 levels

  2009influential reference
• Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin*

  2009cited by this paper
• A role for SNX5 in the regulation of macropinocytosis

  2008cited by this paper
• Salmonellae interplay with host cells

  2008cited by this paper
• PIKfyve: Partners, significance, debates and paradoxes

  2008cited by this paper
• A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

  2008cited by this paper
• PIKfyve Negatively Regulates Exocytosis in Neurosecretory Cells*

  2008cited by this paper
• SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34

  2008cited by this paper
• The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network

  2007cited by this paper
• Salmonella Trafficking is Defined by Continuous Dynamic Interactions with the Endolysosomal System

  2007cited by this paper
• ImageJ for microscopy.

  2007cited by this paper
• High-content screening.

  2007cited by this paper
• The secreted Salmonella dublin phosphoinositide phosphatase, SopB, localizes to PtdIns(3)P-containing endosomes and perturbs normal endosome to lysosome trafficking.

  2006cited by this paper
• The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport

  2006cited by this paper
• CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway1

  2006cited by this paper
• Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole*

  2006cited by this paper
• CellProfiler: image analysis software for identifying and quantifying cell phenotypes

  2006cited by this paper
• Visualisation of macropinosome maturation by the recruitment of sorting nexins

  2006cited by this paper
• Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells.

  2005cited by this paper
• Cloning Vectors and Fluorescent Proteins Can Significantly Inhibit Salmonella enterica Virulence in Both Epithelial Cells and Macrophages: Implications for Bacterial Pathogenesis Studies

  2005cited by this paper
• Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation

  2004cited by this paper
• Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

  2004cited by this paper
• Dynein-mediated vesicle transport controls intracellular Salmonella replication.

  2004cited by this paper
• SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system.

  2003cited by this paper
• The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion.

  2003cited by this paper
• Role of ESCRT-I in Retroviral Budding

  2003cited by this paper
• SseA acts as the chaperone for the SseB component of the Salmonella Pathogenicity Island 2 translocon

  2003influential reference
• Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies.

  2003cited by this paper
• SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells.

  2003cited by this paper
• Active PIKfyve Associates with and Promotes the Membrane Attachment of the Late Endosome-to-trans-Golgi Network Transport Factor Rab9 Effector p40*

  2003cited by this paper
• Phosphatidylinositol 3,5-bisphosphate: metabolism and function.

  2002cited by this paper
• Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

  2002cited by this paper
• Infection of Synovial Fibroblasts in Culture by Yersinia enterocolitica and Salmonella enterica Serovar Enteritidis: Ultrastructural Investigation with Respect to the Pathogenesis of Reactive Arthritis

  2001cited by this paper
• Salmonella pathogenicity islands encoding type III secretion systems.

  2001cited by this paper
• Mammalian Cell Morphology and Endocytic Membrane Homeostasis Require Enzymatically Active Phosphoinositide 5-Kinase PIKfyve*

  2001cited by this paper
• PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation.

  2000cited by this paper
• Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells

  2000cited by this paper
• Complementation Analysis in PtdInsPKinase-deficient Yeast Mutants Demonstrates ThatSchizosaccharomyces pombe and Murine Fab1p Homologues Are Phosphatidylinositol 3-Phosphate 5-Kinases*

  1999cited by this paper
• Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes

  1999cited by this paper
• pH‐dependent secretion of SseB, a product of the SPI‐2 type III secretion system of Salmonella typhimurium

  1999cited by this paper
• The rab7 GTPase controls the maturation of Salmonella typhimurium‐containing vacuoles in HeLa cells

  1999cited by this paper
• Cloning, Characterization, and Expression of a Novel Zn2+-Binding FYVE Finger-Containing Phosphoinositide Kinase in Insulin-Sensitive Cells

  1999cited by this paper
• Biogenesis of Salmonella typhimurium‐containing vacuoles in epithelial cells involves interactions with the early endocytic pathway

  1999cited by this paper
• Mutations in Salmonella Pathogenicity Island 2 (SPI2) Genes Affecting Transcription of SPI1 Genes and Resistance to Antimicrobial Agents

  1998cited by this paper
• The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae.

  1998cited by this paper
• Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains*

  1998cited by this paper
• SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase.

  1998cited by this paper
• Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

  1997cited by this paper
• A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages

  1996cited by this paper
• Acidification of phagosomes containing Salmonella typhimurium in murine macrophages

  1996cited by this paper
• Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors

  1995cited by this paper
• The rab7 GTPase resides on a vesicular compartment connected to lysosomes.

  1995cited by this paper
• Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches

  1994cited by this paper
• Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

  1993cited by this paper
• Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells.

  1993cited by this paper
• Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.

  1992cited by this paper
• Cytopathogenic Effect of Salmonella typhi GIFU 10007 on M cells of Murine Ileal Peyer's Patches in Ligated Ileal Loops: An Ultrastructural Study

  1986cited by this paper
• Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

  1981cited by this paper
• New EMBO Member’s Review THE EMBO JOURNAL

  year unknowncited by this paper

• Edwardsiella piscicida employs C3 derivative to mediate internalization and infection via the teleost-specific receptor

  2025cites this paper
• Monitoring intracellular replication dynamics unveils high proportion of non-replicating antibiotic-tolerant Staphylococcus aureus inside osteoblasts

  2025cites this paper
• Lysosomal BK Channels as an Emerging Therapeutic Target for Lysosomal Dysfunction

  2025cites this paper
• Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities

  2025cites this paper
• PHENOTYPIC DETECTION OF PLASMID FROM CIPROFLOXACIN RESISTANT SALMONELLA TYPHI ISOLATED FROM STOOL OF NSUK STUDENTS

  2024cites this paper
• PIKFYVE deficiency induces vacuole-like cataract via perturbing late endosome homeostasis.

  2024cites this paper
• Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling

  2024cites this paper
• Antimicrobial resistance and virulence genes of invasive Salmonella enterica from children with bacteremia in north-central Nigeria

  2023cites this paper
• Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication

  2023cites this paper
• Macropinocytosis: mechanisms and regulation.

  2023cites this paper
• A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes

  2023cites this paper
• PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

  2021cites this paper
• Genetic factors affect the susceptibility to bacterial infections in diabetes

  2021cites this paper
• Better Together: Current Insights Into Phagosome-Lysosome Fusion

  2021cites this paper
• Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID.

  2021cites this paper
• Role of the ESCRT‐III complex in controlling integrity of the Salmonella‐containing vacuole

  2020cites this paper
• RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells

  2020cites this paper
• Proteoglycan-Dependent Endo-Lysosomal Fusion Affects Intracellular Survival of Salmonella Typhimurium in Epithelial Cells

  2020cites this paper
• Plasmid-Mediated Quinolone Resistance Genes Associated With Ciprofloxacin Resistance in Salmonella Typhimurium from Cattle Faeces from Abattoir in Keffi, Nasarawa State, Nigeria

  2020cites this paper
• A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

  2019cites this paper
• Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.

  2019cites this paper
• From hitchhiker to hijacker: pathogen exploitation of endosomal phosphoinositides 1.

  2019cites this paper
• PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice

  2019cites this paper
• The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

  2018cites this paper
• PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel

  2018cites this paper
• Resolution of macropinosomes, phagosomes and autolysosomes: Osmotically driven shrinkage enables tubulation and vesiculation

  2018cites this paper
• PIKfyve regulates melanosome biogenesis

  2018cites this paper
• Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry.

  2018cites this paper
• PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

  2018cites this paper
• Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

  2017cites this paper
• Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrin- and Caveolin-Mediated Endocytosis to Endosome and Lysosome

  2017cites this paper
• Salmonella effector SopD2 interferes with Rab34 function

  2017cites this paper
• Development of Three Orthogonal Assays Suitable for the Identification and Qualification of PIKfyve Inhibitors

  2017cites this paper
• SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell

  2017cites this paper
• Screening of Food Handlers for Salmonella and Staphylococcus aureus Carriers at University Cafeterias in Khartoum

  2016cites this paper
• Elucidating the Role of Phosphoinositides in Melanogenesis: PIKfyve Regulates Melanogenic Processes through the Synthesis of PI(3,5)P2 and PI(5)P

  2016cites this paper
• Clathrin independent endocytosis

  2016cites this paper
• PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

  2016cites this paper
• Attacking the supply wagons to starve cancer cells to death

  2016cites this paper
• Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth

  2016cites this paper
• Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.

  2016cites this paper
• MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole

  2016cites this paper
• Human Genome-Wide RNAi Screen for Host Factors That Facilitate Salmonella Invasion Reveals a Role for Potassium Secretion in Promoting Internalization

  2016cites this paper
• Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

  2016cites this paper
• The Role of PIKfyve in Toll-Like Receptor-Mediated Responses

  2015cites this paper
• Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages

  2015cites this paper
• Vaccinia Virus Infection Requires Maturation of Macropinosomes

  2015influential citation
• Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

  2015cites this paper
• Survival Strategies of Intracellular Bacterial Pathogens

  2015cites this paper
• Phagocytosis of Filamentous Bacteria: Impact of Target Morphology on Phagosomal Maturation

  2015cites this paper
• The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

  2014cites this paper
• Cancer insights through macropinocytosis: a role for sorting nexins?

  2014cites this paper
• Phosphatidylinositol 3,5‐bisphosphate: Low abundance, high significance

  2014cites this paper
• Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

  2014cites this paper
• A Lysosomal Calcium Channel Regulates Membrane Trafficking During Phagocytosis.

  2014cites this paper
• Characterization of Efferosome Maturation and the Processing of Apoptotic Bodies

  2014cites this paper
• Role of PIKfyve in platelet lysosomal homeostasis

  2014cites this paper
• Live imaging of endosome dynamics.

  2014cites this paper
• Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB

  2014influential citation
• PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

  2014cites this paper
• The Antimicrobial Functions of Macrophages

  2014cites this paper
• Antibacterial and Phytochemical Properties of Some Nigerian Medicinal plants on Salmonella Species Isolated from Human Stool in Owo

  2014cites this paper
• Host PI(3,5)P2 Activity Is Required for Plasmodium berghei Growth During Liver Stage Infection

  2014cites this paper
• Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes

  2013cites this paper
• Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis.

  2013cites this paper
• PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses

  2013cites this paper
• Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

  2013cites this paper
• Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.

  2013cites this paper
• Signaling by the phosphoinositide 3-kinase family in immune cells.

  2013cites this paper
• Endosomal Maturation, Rab7 GTPase and Phosphoinositides in African Swine Fever Virus Entry

  2012cites this paper
• SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages

  2012influential citation
• Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.

  2012cites this paper
• The Rab family of proteins: 25 years on.

  2012cites this paper
• The PIKfyve Inhibitor YM201636 Blocks the Continuous Recycling of the Tight Junction Proteins Claudin-1 and Claudin-2 in MDCK cells

  2012cites this paper
• Spatiotemporal Localization of Rab20 in Live RAW264 Macrophages during Macropinocytosis

  2012cites this paper
• PIKfyve and its Lipid products in health and in sickness.

  2012cites this paper
• Phosphatidylinositol‐3,5‐Bisphosphate: No Longer the Poor PIP2

  2012cites this paper
• Gulping rather than sipping: macropinocytosis as a way of virus entry.

  2012cites this paper
• The Phosphoinositides: Key Regulators of Salmonella Containing Vacuole (SCV) Trafficking and Identity

  2012cites this paper
• The Bimodal Lifestyle of Intracellular Salmonella in Epithelial Cells: Replication in the Cytosol Obscures Defects in Vacuolar Replication

  2012cites this paper
• MICROBIAL CONTAMINATION OF AN INDIGENOUS LEAFY VEGETABLE, ROSELLE (Hibiscus sabdariffa L.) AND ASSOCIATED RISK FACTORS ON FARM AND MARKET SAMPLES IN THE KASENA- NANKANA EAST MUNICIPALITY OF THE UPPER EAST REGION

  2012cites this paper
• The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection

  2012cites this paper
• Rab GTPases and Their Interacting Proteins in Health and Disease

  2012cites this paper
• Macropinocytosis is responsible for the uptake of pathogenic and non-pathogenic mycobacteria by B lymphocytes (Raji cells)

  2012cites this paper
• TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

  2012influential citation
• Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.

  2012cites this paper
• Vps26A and Vps26B Subunits Define Distinct Retromer Complexes

  2011cites this paper
• Proteomic analysis of Salmonella-host interactions reveals novel host targets of SopB

  2011cites this paper
• Linear models for endocytic transformations from live cell imaging

  2011cites this paper
• Macropinocytosis: an endocytic pathway for internalising large gulps

  2011cites this paper
• Sculpting the immune response to infection

  2011cites this paper
• Subversion of membrane transport pathways by vacuolar pathogens

  2011cites this paper
• Australia and New Zealand Society for Cell and Developmental Biology

  2010cites this paper
• Salmonella vacuole maturation: PIKfyve leads the way

  2010cites this paper
• The SNX-PX-BAR Family in Macropinocytosis: The Regulation of Macropinosome Formation by SNX-PX-BAR Proteins

  2010cites this paper