Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular and Cellular Biology

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.25.15.6821-6833.2005PMID 16024814PMCID PMC1190352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reactive Oxygen Species Promote TNF -Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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• ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3

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• Signaling of Apoptosis through TLRs Critically Involves Toll/IL-1 Receptor Domain-Containing Adapter Inducing IFN-β, but Not MyD88, in Bacteria-Infected Murine Macrophages1

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• Necrosis‐like cell death induced by bacteria in mouse macrophages

  2004influential reference
• The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

  2004cited by this paper
• Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

  2004cited by this paper
• The Up-regulation of Human Caspase-8 by Interferon-γ in Breast Tumor Cells Requires the Induction and Action of the Transcription Factor Interferon Regulatory Factor-1*

  2004cited by this paper
• Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels.

  2004cited by this paper
• Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

  2004cited by this paper
• STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7*

  2004cited by this paper
• STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex.

  2003cited by this paper
• STAT-1α and IFN-γ as Modulators of TNF-α Signaling in Macrophages: Regulation and Functional Implications of the TNF Receptor 1:STAT-1α Complex1

  2003cited by this paper
• A caspaselike activity is triggered by LPS and is required for survival of human dendritic cells.

  2003cited by this paper
• Orphan Nuclear Receptor Nur77 Is Involved in Caspase-independent Macrophage Cell Death

  2003cited by this paper
• Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils.

  2003cited by this paper
• Mechanisms of Caspase-Independent Neuronal Death: Energy Depletion and Free Radical Generation

  2003cited by this paper
• Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages*

  2003cited by this paper
• Regulation of Necrosis of H9c2 Myogenic Cells upon Transient Energy Deprivation

  2003cited by this paper
• Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.

  2002cited by this paper
• Cooperation of STAT-1 and IRF-1 in Interferon-γ-induced Transcription of the gp91 phox Gene*

  2002cited by this paper
• TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

  2002cited by this paper
• The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis

  2002cited by this paper
• The immunopathogenesis of sepsis

  2002cited by this paper
• Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription of the gp91(phox) gene.

  2002cited by this paper
• Specific involvement of caspases in the differentiation of monocytes into macrophages.

  2002cited by this paper
• Interferon γ Is Required for Activation-induced Death of T Lymphocytes

  2002cited by this paper
• NF-kappaB at the crossroads of life and death.

  2002cited by this paper
• Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition

  2002cited by this paper
• NF-κB at the crossroads of life and death

  2002cited by this paper
• TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

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• IFN-γ/TNF-α Synergism as the Final Effector in Autoimmune Diabetes: A Key Role for STAT1/IFN Regulatory Factor-1 Pathway in Pancreatic β Cell Death1

  2001cited by this paper
• Four deaths and a funeral: from caspases to alternative mechanisms

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  2001cited by this paper
• Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701*

  2001cited by this paper
• Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis*

  2001cited by this paper
• Toll-like receptors: critical proteins linking innate and acquired immunity

  2001cited by this paper
• Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages.

  2001influential reference
• IFN-β induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7

  2000cited by this paper
• Necrotic Death Pathway in FAS Receptor Signaling

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000influential reference
• Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation

  2000cited by this paper
• Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

  2000cited by this paper
• Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells

  2000cited by this paper
• Ocular toxoplasmosis: new directions for clinical investigation

  2000cited by this paper
• Selective Involvement of Superoxide Anion, but Not Downstream Compounds Hydrogen Peroxide and Peroxynitrite, in Tumor Necrosis Factor-α-induced Apoptosis of Rat Mesangial Cells*

  2000cited by this paper
• Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

  2000cited by this paper
• Microglia as mediators of inflammatory and degenerative diseases.

  1999cited by this paper
• Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.

  1999cited by this paper
• Redox regulation of cellular signalling.

  1999cited by this paper
• p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

  1999cited by this paper
• Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

  1999cited by this paper
• More than one way to die: apoptosis, necrosis and reactive oxygen damage

  1999cited by this paper
• Caspase Activation Is Required for T Cell Proliferation

  1999cited by this paper
• HMG-1 as a late mediator of endotoxin lethality in mice.

  1999cited by this paper
• Resistance to the Cytotoxic Effects of Tumor Necrosis Factor α Can Be Overcome by Inhibition of a FADD/Caspase-dependent Signaling Pathway*

  1999influential reference
• STAT1 Is Inactivated by a Caspase*

  1998cited by this paper
• Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages.

  1998cited by this paper
• Activation of the JAK-STAT pathway by reactive oxygen species.

  1998cited by this paper
• Host Tissue Damage by Phagocytes

  1997cited by this paper
• Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis

  1997cited by this paper
• Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

  1997cited by this paper
• Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases.

  1997cited by this paper
• [Redox regulation of cellular signaling].

  1997cited by this paper
• Synovial tissue macrophage populations and articular damage in rheumatoid arthritis.

  1996cited by this paper
• Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.

  1996cited by this paper
• Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.

  1994cited by this paper
• Endotoxins and disease mechanisms.

  1987cited by this paper

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• Reactive oxygen species‐induced parthanatos of immunocytes by human cytomegalovirus‐associated substance

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• ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

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• Anti-apoptotic activity of Japanese encephalitis virus NS5 protein in human medulloblastoma cells treated with interferon-β.

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